Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

SkinMedica TNS® Advanced+ Serum Versus SkinMedica HA5 Rejuvenating Hydrator

SkinMedica TNS® Advanced+ Serum Versus SkinMedica HA5 Rejuvenating Hydrator Detailed comparison of SkinMedica TNS® Advanced+ Serum versus SkinMedica HA5 Rejuvenating Hydrator. This hydrating serum is formulated around Sodium Hyaluronate Crosspolymer and Hydrol

This source-based comparison does not add ratings or recommend a winner.

SkinMedica TNS® Advanced+ Serum Versus SkinMedica HA5 Rejuvenating Hydrator Detailed comparison of SkinMedica TNS® Advanced+ Serum versus SkinMedica HA5 Rejuvenating Hydrator. This hydrating serum is formulated around Sodium Hyaluronate Crosspolymer and Hydrolyzed Hyaluronic Acid to hydrate skin and soften the look of wrinkles. Water Pentylene Glycol Human Neonatal Fibroblast Conditioned Media Glycereth-7 Triacetate Shea Butter Ethyl Esters Glycerin Ethoxydiglycol Lactococcus Ferment Lysate Whey Protein Chlorella Vulgaris Extract Saccharide Isomerate Dimer Tripeptide-43 Vitis Vinifera Flower Cell Extract Pyrus Malus Fruit Extract Hydroxyacetophenone Tocopheryl Acetate Propanediol Xanthan Gum Polyacrylate Crosspolymer-6 Polyacrylate-13 Polyisobutene Sclerotium Gum PEG-12 Dimethicone Lecithin Pullulan Butylene Glycol Sodium Citrate Polysorbate 20 Aminomethyl Propanol Disodium EDTA Phenoxyethanol Ethylhexylglycerin Water, Pentylene Glycol, Human Neonatal Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin Dimethicone Hdi/Trimethylol Hexyllactone Crosspolymer Bis-PEG-8 Dimethicone Polysilicone-11 Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Sodium Hyaluronate Crosspolymer Hydrolyzed Hyaluronic Acid Sodium Hyaluronate Vibrio Alginolyticus Ferment Filtrate Alteromonas Ferment Extract Porphyridium Cruentum Extract Plankton Extract Trehalose Urea Serine Algin Caprylyl Glycol Disodium Phosphate Potassium Phosphate Polymethylsilsesquioxane Glyceryl Polyacrylate Sea Water Sucrose Palmitate Polysorbate 60 Potassium Sorbate Citric Acid Isohexadecane Polysorbate 80 Silica Decyl Glucoside Tromethamine Water, Dimethicone, Hdi/Trimethylol Hexyllactone Crosspolymer, Glycerin, Butylene Glycol, Bis-PEG-8 Dimethicone, Polysilicone-11, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Hyaluronate Crosspolymer, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Vitis Vinifera Flower Cell Extract, Vibrio Alginolyticus Ferment Filtrate, Alteromonas Ferment Extract, Porphyridium Cruentum Extract, Whey Protein, Plankton Extract, Trehalose, Urea, Serine, Algin, Caprylyl Glycol, Pullulan, Disodium Phosphate, Potassium Phosphate, Pentylene Glycol, Polymethylsilsesquioxane, Glyceryl Polyacrylate, Sodium Citrate, Sea Water, Sucrose Palmitate, Tocopheryl Acetate, Hydroxyacetophenone, Polysorbate 60, Propanediol, Potassium Sorbate, Citric Acid, Isohexadecane, Polysorbate 80, Silica, Decyl Glucoside, Tromethamine, Ethylhexylglycerin, Phenoxyethanol, Disodium EDTA Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Butylene Glycol (or BG) is used within cosmetic products for a few different reasons: Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients. Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness. Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air. This ingredient mainly works behind the scenes and helps with: On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it. One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin). Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption. You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%. Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that: The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure. Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine. Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster. As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress. Though it can't kill microbes on its own,