Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

Structural Comparison

Amino acid sequence Gly-His-Lys Gly-His-Lys (same) Modification Copper(II) ion complexation Palmitoyl fatty acid chain (C16) at N-terminus Copper content Yes, copper(II) bound at 1:1 ratio None Molecular formula C14H23CuN6O4 C30H52N6O5 (approximate) Molecular

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  • Amino acid sequence
  • Gly-His-Lys
  • Gly-His-Lys (same)
  • Modification
  • Copper(II) ion complexation
  • Palmitoyl fatty acid chain (C16) at N-terminus
  • Copper content
  • Yes, copper(II) bound at 1:1 ratio
  • None
  • Molecular formula
  • C14H23CuN6O4
  • C30H52N6O5 (approximate)
  • Molecular weight
  • approximately 401.91 g/mol
  • approximately 580 Da (approximate)
  • Appearance
  • Blue to blue-purple powder
  • White to off-white powder
  • Water solubility
  • Good
  • Reduced (lipid solubility enhanced)
  • Lipid solubility
  • Moderate
  • Enhanced (by palmitoyl group)
  • Matrixyl 3000 is not a single compound but a commercial combination of two palmitoylated peptides: - Palmitoyl tripeptide-1 (Pal-GHK): Shares GHK sequence, fatty acid modified - Palmitoyl tetrapeptide-7 (Pal-GQPR): Targets IL-6 and inflammatory pathways
  • When comparing GHK-Cu with Matrixyl 3000 in research, it is important to specify which component of Matrixyl 3000 is being compared, since the two components have different mechanisms.