Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

The Ordinary "Buffet" Versus Neogen Real Peptide Serum

The Ordinary "Buffet" Versus Neogen Real Peptide Serum Detailed comparison of The Ordinary "Buffet" versus Neogen Real Peptide Serum. This anti-aging serum is formulated around Lactococcus Ferment Lysate and Acetyl Hexapeptide-8 to soften the look of wrinkles.

This source-based comparison does not add ratings or recommend a winner.

The Ordinary "Buffet" Versus Neogen Real Peptide Serum Detailed comparison of The Ordinary "Buffet" versus Neogen Real Peptide Serum. This anti-aging serum is formulated around Lactococcus Ferment Lysate and Acetyl Hexapeptide-8 to soften the look of wrinkles. This anti-aging serum is formulated around Niacinamide and Palmitoyl Tripeptide-5 to soften the look of wrinkles and refine skin texture. Water Glycerin Lactococcus Ferment Lysate Acetyl Hexapeptide-8 Pentapeptide-18 Palmitoyl Tripeptide-1 Palmitoyl Tetrapeptide-7 Palmitoyl Tripeptide-38 Dipeptide Diaminobutyroyl Benzylamide Diacetate Acetylarginyltryptophyl Diphenylglycine Sodium Hyaluronate Crosspolymer Sodium Hyaluronate Allantoin Glycine Alanine Serine Valine Isoleucine Proline Threonine Histidine Phenylalanine Arginine Aspartic Acid Trehalose Fructose Glucose Maltose Urea Sodium PCA PCA Sodium Lactate Citric Acid Hydroxypropyl Cyclodextrin Sodium Chloride Sodium Hydroxide Butylene Glycol Pentylene Glycol Acacia Senegal Gum Xanthan Gum Carbomer Polysorbate 20 PPG-26-Buteth-26 PEG-40 Hydrogenated Castor Oil Trisodium Ethylenediamine Disuccinate Ethoxydiglycol Sodium Benzoate Caprylyl Glycol Ethylhexylglycerin Phenoxyethanol Chlorphenesin Water, Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin Dipropylene Glycol Propanediol Niacinamide Caprylic/Capric Triglyceride 1,2-Hexanediol Hydroxyethyl Urea Diethoxyethyl Succinate Acrylates/C10-30 Alkyl Acrylate Crosspolymer Tromethamine Polyglyceryl-10 Laurate Inonotus Obliquus Extract Adenosine Cyamopsis Tetragonoloba Gum Agar Ubiquinone Tropaeolum Majus Flower/Leaf/Stem Extract Palmitoyl Tripeptide-5 Morinda Citrifolia Leaf Extract Morinda Citrifolia Flower Extract Coccinia Indica Fruit Extract Moringa Oleifera Seed Oil Solanum Melongena Fruit Extract Simmondsia Chinensis Seed Oil Curcuma Longa Root Extract Corallina Officinalis Extract Ocimum Sanctum Leaf Extract Copper Tripeptide-1 Tripeptide-1 Tripeptide-29 Palmitoyl Pentapeptide-4 Hexapeptide-12 Hexapeptide-9 Tripeptide-2 Nonapeptide-1 Hexapeptide-11 Water, Dipropylene Glycol, Propanediol, Glycerin, Niacinamide, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Hydroxyethyl Urea, Diethoxyethyl Succinate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Tromethamine, Polyglyceryl-10 Laurate, Inonotus Obliquus Extract, Xanthan Gum, Ethylhexylglycerin, Adenosine, Cyamopsis Tetragonoloba Gum, Sodium Hyaluronate, Agar, Ubiquinone, Tropaeolum Majus Flower/Leaf/Stem Extract, Palmitoyl Tripeptide-5, Morinda Citrifolia Leaf Extract, Morinda Citrifolia Flower Extract, Coccinia Indica Frui Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative". It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time. The comparison to Botox does have limits because the molecule is water-loving and relatively large. Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles. So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging. A 12 week human study of a multi-ingredient regimen containing this ingredient saw: While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone). Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations. Butylene Glycol (or BG) is used within cosmetic products for a few different reasons: Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients. Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness. Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that: The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure. Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations. Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum. Topically, glycerin does several things at once: Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3. Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin. This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products. Just know very high concentrations (>40%) can feel tacky in low humidity. Glycerin is the name for this ingredient in American English. Bri