The Outset Restorative Niacinamide Night Cream Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment

The Outset Restorative Niacinamide Night Cream Versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment Detailed comparison of The Outset Restorative Niacinamide Night Cream versus Paula's Choice Clinical 0.3% Retinol + 2% Bakuchiol Treatment. This barrier-repair night moisturizer is formulated around Niacinamide and Bakuchiol to strengthen the skin barrier. This anti-aging treatment is formulated around Bakuchiol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. Water Caprylic/Capric Triglyceride Cetyl Palmitate Propanediol Hydrogenated Sunflower Seed Oil Polyglyceryl-3 Esters Glycerin Helianthus Annuus Seed Oil Myristyl Myristate Dicaprylyl Carbonate Hydrogenated Ethylhexyl Olivate Hydrogenated Sunflower Seed Oil Glyceryl Esters Oenothera Biennis Oil Pentylene Glycol Vitis Vinifera Seed Oil Hydrogenated Vegetable Oil Persea Gratissima Oil Niacinamide Cassia Angustifolia Seed Polysaccharide Bakuchiol Chamomilla Recutita Flower Extract Citrus Aurantium Dulcis Fruit Extract Citrus Limon Fruit Extract Saccharum Officinarum Extract Acer Saccharum Extract Vaccinium Myrtillus Fruit/Leaf Extract Glycyrrhiza Glabra Root Extract Glycine Soja Oil Hydrogenated Olive Oil Unsaponifiables Hydrolyzed Jojoba Esters Jojoba Esters Sodium Hyaluronate Phenoxyethanol Cetearyl Alcohol Microcrystalline Cellulose Capryloyl Glycerin/Sebacic Acid Copolymer Sodium Stearoyl Lactylate Acacia Senegal Gum Diheptyl Succinate Xanthan Gum Cellulose Gum Saccharide Isomerate Panthenol Caprylyl Glycol Tocopherol Tocopheryl Acetate Dextran Trifluoroacetyl Tripeptide-2 Citric Acid Sodium Citrate Sodium Phytate Water, Caprylic/Capric Triglyceride, Cetyl Palmitate, Propanediol, Hydrogenated Sunflower Seed Oil Polyglyceryl-3 Esters, Glycerin, Helianthus Annuus Seed Oil, Myristyl Myristate, Dicaprylyl Carbonate, Hydrogenated Ethylhexyl Olivate, Hydrogenated Sunflower Seed Oil Glyceryl Esters, Oenothera Biennis Oil, Pentylene Glycol, Vitis Vinifera Seed Oil, Hydrogenated Vegetable Oil, Persea Gratissima Oil, Niacinamide, Cassia Angustifolia Seed Polysaccharide, Bakuchiol, Chamomilla Recutita Flower Extract, Citrus Aurantium Dulcis Fruit Extract, Citrus Limon Fruit Extract, Saccharum Officinarum Extract, Acer Saccharum Extract, Vaccinium Myrtillus Fruit/Leaf Extract, Glycyrrhiza Glabra Root Extract, Glycine Soja Oil, Hydrogenated Olive Oil Unsaponifiables, Hydrolyzed Jojoba Esters, Jojoba Esters, Sodium Hyaluronate, Phenoxyethanol, Cetearyl Alcohol, Microcrystalline Cellulose, Capryloyl Glycerin/Sebacic Acid Copolymer, Sodium Stearoyl Lactylate, Acacia Senegal Gum, Diheptyl Succinate, Xanthan Gum, Cellulose Gum, Saccharide Isomerate, Panthenol, Caprylyl Glycol, Tocopherol, Tocopheryl Acetate, Dextran, Trifluoroacetyl Tripeptide-2, Citric Acid, Sodium Citrate, Sodium Phytate Dimethicone Pentaerythrityl Tetraisostearate Isononyl Isononanoate Butylene Glycol Arachidyl Alcohol Glyceryl Polymethacrylate Dimethicone Crosspolymer Behenyl Alcohol PEG-75 Shea Butter Glycerides Glyceryl Stearate C12-15 Alkyl Benzoate Polysorbate 20 Tetrahexyldecyl Ascorbate Retinol Ceramide Ng Palmitoyl Tetrapeptide-7 Palmitoyl Hexapeptide-12 Dipotassium Glycyrrhizate Avena Sativa Kernel Extract Arctium Lappa Root Extract Salix Alba Bark Extract Glycine Soja Sterols Lecithin Allantoin Hydrolyzed Soy Protein Palmitoyl Tripeptide-1 Sodium Hydroxide Tribehenin Dipeptide-2 Polygonum Cuspidatum Root Extract PEG-10 Phytosterol PEG-8 Magnesium Aluminum Silicate Arachidyl Glucoside Be the first to review These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. Bakuchiol is a plant-derived antioxidant from the seeds of the Psoralea corylifolia plant. It has antimicrobial, emollient, skin conditioning, and antioxidant properties. You'll likely see it called a "retinol replacement" but the two are technically not related. This is because bakuchiol is able to flip many of the same switches in your skin cells to tell them to: 1) produce more collagen (type I, III, and IV) 2) activate the same genes retinoids do Unlike retinoids, this ingredient will not increase photosensitivity and is safe to use during pregnancy (but please still check in with your doctor!). The flagship clinical trial from Dhaliwal et al. 2019 found 0.5% bakuchiol (twice daily) and 0.5% retinol (once daily) reduced wrinkles and hyperpigmentation equally, but bakuchiol had significantly less irritation. Systematic reviews also back this up: Bakuchiol is comparable to retinol for photoaging but with better tolerability. It also has mild antibacterial properties against Cutibacterium acnes and antifungal activity in vitro against Candida and dermatophytes. The reason bakuchiol works well is due to its structure; it is a meroterpene phenol, or a hybrid molecule. The phenol half acts as an antioxidant while the terpene half is fat-loving. This helps the molecule slip through the skin barrier. This ingredient is usually used between 0.5-2%. Only one case of contact dermatitis has ever been reported for this ingredient. Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created. Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin. Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on). Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier. Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient. It plays several roles in a formula: Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products. Multiple assessments have found it to be non-irritating and non-sensitizing to most people. However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers. Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy. Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal