Peptide Skincare & BeautySkin science and ingredient guides

Ingredient or product comparison

ZO Skin Health Daily Power Defense Versus Paula's Choice Calm Repairing Serum

ZO Skin Health Daily Power Defense Versus Paula's Choice Calm Repairing Serum Detailed comparison of ZO Skin Health Daily Power Defense versus Paula's Choice Calm Repairing Serum. This barrier-repair moisturizer is formulated around Laminaria Digitata Extract

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ZO Skin Health Daily Power Defense Versus Paula's Choice Calm Repairing Serum Detailed comparison of ZO Skin Health Daily Power Defense versus Paula's Choice Calm Repairing Serum. This barrier-repair moisturizer is formulated around Laminaria Digitata Extract and Beta-Glucan to strengthen the skin barrier and hydrate skin. This calming serum is formulated around Sodium Hyaluronate and Ceramide NP to calm redness and strengthen the skin barrier. Water Dicaprylyl Carbonate Cetearyl Isononanoate Glycerin Pentylene Glycol Cetearyl Alcohol Steareth-20 Safflower Oil/Palm Oil Aminopropanediol Esters Laminaria Digitata Extract Opuntia Ficus-Indica Stem Extract Arabidopsis Thaliana Extract Marrubium Vulgare Meristem Cell Culture Leontopodium Alpinum Meristem Cell Culture Retinyl Palmitate Tocopheryl Acetate Tocopherol Micrococcus Lysate Caprylyl Glycol Hexylene Glycol Lactose Galactoarabinan Lecithin Schizophyllan Beta-Glucan 1,2-Hexanediol Carbomer Cellulose Maltodextrin C14-22 Alcohols Cetearyl Glucoside C12-20 Alkyl Glucoside Hydroxypropyl Methylcellulose Disodium EDTA Sodium Hydroxide Phenoxyethanol Ethylhexylglycerin Sodium Benzoate Parfum CI 77007 Limonene Water, Dicaprylyl Carbonate, Cetearyl Isononanoate, Glycerin, Pentylene Glycol, Cetearyl Alcohol, Steareth-20, Safflower Oil/Palm Oil Aminopropanediol Esters, Laminaria Digitata Extract, Opuntia Ficus-Indica Stem Extract, Arabidopsis Thaliana Extract, Marrubium Vulgare Meristem Cell Culture, Leontopodium Alpinum Meristem Cell Culture, Retinyl Palmitate, Tocopheryl Acetate, Tocopherol, Micrococcus Lysate, Caprylyl Glycol, Hexylene Glycol, Lactose, Galactoarabinan, Lecithin, Schizophyllan, Beta-Glucan, 1,2-Hexanediol, Carbomer, Cellulose, Maltodextrin, C14-22 Alcohols, Cetearyl Glucoside, C12-20 Alkyl Glucoside, Hydroxypropyl Methylcellulose, Disodium EDTA, Sodium Hydroxide, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate, Parfum, CI 77007, Limonene Sodium Lauroyl Lactylate Sodium Hyaluronate Polysorbate 20 Caprylic/Capric Triglyceride PEG/PPG-14/4 Dimethicone Xanthan Gum Sodium Cocoyl Amino Acids Ceramide NP Epilobium Angustifolium Extract Ceramide AP Cholesterol Phytosphingosine Sarcosine Chrysanthemum Parthenium Flower Extract Sea Whip Extract Glycine Soja Seed Extract Hyaluronic Acid Glycyrrhiza Glabra Root Extract Ceramide EOP Magnesium Aspartate Potassium Aspartate Ubiquinone Leuconostoc/Radish Root Ferment Filtrate Calcium Chloride Propylene Glycol Sodium Metabisulfite Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate Potassium Sorbate Water, Glycerin, Sodium Lauroyl Lactylate, Sodium Hyaluronate, Polysorbate 20, Caprylic/Capric Triglyceride, PEG/PPG-14/4 Dimethicone, Xanthan Gum, Disodium EDTA, Sodium Cocoyl Amino Acids, Ceramide NP, Ethylhexylglycerin, Epilobium Angustifolium Extract, Ceramide AP, Cholesterol, Phytosphingosine, Beta-Glucan, Sarcosine, Carbomer, Chrysanthemum Parthenium Flower Extract, Sea Whip Extract, Glycine Soja Seed Extract, Hyaluronic Acid, Glycyrrhiza Glabra Root Extract, Ceramide EOP, Magnesium Aspartate, Potassium Aspartate, Ubiquinone, Phenoxyethanol, 1,2-Hexanediol, Caprylyl Glycol, Leuconostoc/Radish Root Ferment Filtrate, Calcium Chloride, Propylene Glycol, Tocopherol, Sodium Metabisulfite, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Benzoate, Potassium Sorbate These ingredients are found in both products. Ingredients higher up in an ingredient list are typically present in a larger amount. 1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. It is a: Humectant, drawing moisture into the skin Emollient, helping to soften skin Solvent, dispersing and stabilizing formulas Preservative booster, enhancing the antimicrobial activity of other preservatives Beta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed. It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent. On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin The more interesting story is underneath: Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair. A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use. It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive. This ingredient gets along with pretty much everything and is typically used around 0.1-1%. Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component. Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created. Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin. Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on). Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture. Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%. It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier. Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%. A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions. Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air. This ingr