Peptide Skincare & BeautySkin science and ingredient guides

Product and ingredient reference

Le Mieux Essence Moisturizer (Discontinued)

Le Mieux Essence Moisturizer (Discontinued) Le Mieux Essence Moisturizer ingredients explained: Hyaluronic Acid, Acetyl Hexapeptide-8, Dipalmitoyl Hydroxyproline, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-5, Ceramide I, Ceramide III, Butyrospermum Parkii

Le Mieux Essence Moisturizer (Discontinued) Le Mieux Essence Moisturizer ingredients explained: Hyaluronic Acid, Acetyl Hexapeptide-8, Dipalmitoyl Hydroxyproline, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-5, Ceramide I, Ceramide III, Butyrospermum Parkii (Shea) Butter, Phospholipids, Soluble Marine Collagen, Dipotassium Glycyrrhizate, Superoxide Dismutase, Beta Glucan, Sodium PCA, Chitosan, Pullulan, Sorbitol, Macrocystis Pyrifera (Brown Algae) Extract, Camellia Sinensis (Green Tea) Distillate, Glucose, Glucose Oxidase, Lactoperoxidase Show all ingredients by function Hyaluronic Acid skin-identical ingredient, moisturizer/​humectant goodie Acetyl Hexapeptide-8 cell-communicating ingredient, moisturizer/​humectant Dipalmitoyl Hydroxyproline Palmitoyl Pentapeptide-4 cell-communicating ingredient Palmitoyl Tripeptide-5 Ceramide I skin-identical ingredient Ceramide III Butyrospermum Parkii (Shea) Butter emollient Phospholipids skin-identical ingredient, emollient Soluble Marine Collagen moisturizer/​humectant Dipotassium Glycyrrhizate soothing, moisturizer/​humectant Superoxide Dismutase antioxidant Beta Glucan Sodium PCA 0, 0 Chitosan Pullulan Sorbitol Macrocystis Pyrifera (Brown Algae) Extract Camellia Sinensis (Green Tea) Distillate Glucose Glucose Oxidase Lactoperoxidase It’s naturally in our skin and behaves there like a sponge It can bind up to 1000 times its own weight in water It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only) High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin) Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study) Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). Expand to read more The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%, while a 5% Argireline formula applied for 28 days did almost the same with a decrease in wrinkle depth by 16.26%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly". This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing. We don't have description for this ingredient yet. A pretty famous and better-researched peptide consisting of five amino acids (the building blocks of all proteins). It was created in a joint effort by the French ingredient supplier, Sederma and the cosmetics industry big shot, Procter&Gamble. The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a subfragment of skin-structu what‑it‑does skin-identical ingredient | moisturizer/humectant cell-communicating ingredient | moisturizer/humectant skin-identical ingredient | emollient moisturizer/humectant soothing | moisturizer/humectant irritancy, com.

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