Peptide Skincare & BeautySkin science and ingredient guides

Product and ingredient reference

SkinMedica Tns Advanced+ Serum

SkinMedica Tns Advanced+ Serum SkinMedica Tns Advanced+ Serum ingredients explained: Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, W

SkinMedica Tns Advanced+ Serum SkinMedica Tns Advanced+ Serum ingredients explained: Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera (Grape) Flower Cell Extract, Pyrus Malus (Apple) Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin Show all ingredients by function Aqua/Water/Eau solvent Pentylene Glycol solvent, moisturizer/​humectant Human Fibroblast Conditioned Media cell-communicating ingredient Glycereth-7 Triacetate emollient, solvent Shea Butter Ethyl Esters emollient Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar Ethoxydiglycol solvent, moisturizer/​humectant, perfuming Lactococcus Ferment Lysate goodie Whey Protein Chlorella Vulgaris Extract Saccharide Isomerate moisturizer/​humectant Dimer Tripeptide-43 Vitis Vinifera (Grape) Flower Cell Extract Pyrus Malus (Apple) Fruit Extract Hydroxyacetophenone antioxidant, preservative Tocopheryl Acetate antioxidant Propanediol Xanthan Gum viscosity controlling Polyacrylate Crosspolymer-6 Polyacrylate-13 Polyisobutene Sclerotium Gum PEG-12 Dimethicone Lecithin emollient, emulsifying Pullulan Butylene Glycol moisturizer/​humectant, solvent 0, 1 Sodium Citrate chelating, buffering Polysorbate 20 emulsifying, surfactant/​cleansing Aminomethyl Propanol buffering Disodium EDTA chelating Phenoxyethanol preservative Ethylhexylglycerin Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. Expand to read more Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens. Human Fibroblast Conditioned Media (HFCM) essentially means a "Growth Factor Cocktail" for your skin. We have written more about the most common GF used in skincare, the Epidermal Growth Factor here, so if you are new to the topic head over there to catch up. The TL;DR version is that a Growth Factor is a medium long amino acid sequence (= small protein = big peptide) that works as a cell signaling molecule to stimulate cell growth, proliferation, healing and/or differentiation. Ingredients called "Conditioned Media" cover not one but a mix of Growth Factors derived from some cells grown in a lab. In the EU, human cell-derived ingredients are illegal, so GF products available in the EU usually use a plant source (e.g. barley). In the US, human-derived GFs are all OK, and Human Fibroblast Conditioned Media is derived, as its name suggests, from human fibroblast cells (VIP skin cells for collagen production). The company Skinmedica was a pioneer in using GFs in cosmeceutical skincare, and their version of HFCM contains a "proprietary mixture of growth factors, cytokines, and soluble matrix proteins secreted by cultured neonatal human dermal fibroblasts during the production of extracellular matrix (ECM)". It is claimed to be a physiologically balanced mix of GFs that are ideal for skin cells to regenerate themselves. More specifically, it contains growth factors that can promote angiogenesis (VEGF and hepatocyte growth factor), modulate inflammation (IL-6 and IL-8), and enhance ECM deposition (TGF-β1 and platelet-derived growth factor-A). Skinmedica has pretty convincing research showing that their products containing GFs (TNS line) work and have great anti-aging benefits. Multiple clinical studies show that the TNS Recovery Complex improves the appearance of fine lines, wrinkles, skin tone and texture. The benefits are even greater when GFs are combined with tried and true anti-aging actives such as antioxidants and retinol. This all so what‑it‑does solvent | moisturizer/humectant emollient | solvent skin-identical ingredient | moisturizer/humectant irritancy, com. solvent | moisturizer/humectant | perfuming moisturizer/humectant antioxidant | preservative emollient | emulsifying moisturizer/humectant | solvent chelating | buffering emulsifying | surfactant/cleansing

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