Skin science article
Allies of Skin Multi Nutrient & Dioic Renewing Cream Versus Allies of Skin Peptide & Antioxidants Firming Daily Treatment
Allies of Skin Multi Nutrient & Dioic Renewing Cream Versus Allies of Skin Peptide & Antioxidants Firming Daily Treatment This brightening moisturizer is formulated around Lactobacillus Ferment and Niacinamide to fade the look of dark spots and strengthen the
Allies of Skin Multi Nutrient & Dioic Renewing Cream Versus Allies of Skin Peptide & Antioxidants Firming Daily Treatment
This brightening moisturizer is formulated around Lactobacillus Ferment and Niacinamide to fade the look of dark spots and strengthen the skin barrier.
This anti-aging moisturizer is formulated around Niacinamide and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and calm redness.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Caprylic/Capric Triglyceride
Lactobacillus Ferment
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer
Albizia Julibrissin Bark Extract
Calophyllum Inophyllum Seed Oil
Niacinamide
Octadecenedioic Acid
Rosa Canina Seed Oil
Simmondsia Chinensis Seed Oil
Squalane
Ribose
Centella Asiatica Leaf Extract
Glycyrrhiza Glabra Root Extract
Saccharomyces/Xylinum/Black Tea Ferment
Mel
Zinc PCA
Camellia Sinensis Leaf Extract
Caffeine
Allantoin
Superoxide Dismutase
Plantago Lanceolata Leaf Extract
Moringa Oleifera Seed Extract
Centella Asiatica Meristem Cell Culture
Syringa Vulgaris Leaf Cell Culture Extract
Palmitoyl Tripeptide-8
Phospholipids
Sodium Hyaluronate
Marrubium Vulgare Meristem Cell Culture
Hydrolyzed Jojoba Esters
Glutamylamidoethyl Imidazole
Bisabolol
Ceramide NP
Hyaluronic Acid
Sphingolipids
Tocopherol
Rosmarinyl Glucoside
Caffeyl Glucoside
Gallyl Glucoside
Tetrahydrodiferuloylmethane
Tetrahydrodemethoxydiferuloylmethane
Tetrahydrobisdemethoxydiferuloylmethane
Maltodextrin
Dextran
Hydroxyethylcellulose
Cetearyl Olivate
Sorbitan Olivate
Xanthan Gum
Isosorbide Dicaprylate
Water, Glycerin, Caprylic/Capric Triglyceride, Lactobacillus Ferment, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Albizia Julibrissin Bark Extract, Calophyllum Inophyllum Seed Oil, Niacinamide, Octadecenedioic Acid, Rosa Canina Seed Oil, Simmondsia Chinensis Seed Oil, Squalane, Ribose, Centella Asiatica Leaf Extract, Glycyrrhiza Glabra Root Extract, Saccharomyces/Xylinum/Black Tea Ferment, Mel, Zinc PCA, Camellia Sinensis Leaf Extract, Caffeine, Allantoin, Superoxide Dismutase, Plantago Lanceolata Leaf Extract, Moringa Oleifera Seed Extract, Centella Asiatica Meristem Cell Culture, Syringa Vulgaris Leaf Cell Culture Extract, Palmitoyl Tripeptide-8, Phospholipids, Sodium Hyaluronate, Marrubium Vulgare Meristem Cell Culture, Hydrolyzed Jojoba Esters, Glutamylamidoethyl Imidazole, Bisabolol, Ceramide NP, Hyaluronic Acid, Sphingolipids, Tocopherol, Rosmarinyl Glucoside, Caffeyl Glucoside, Gallyl Glucoside, Tetrahydrodiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrobisdemethoxydiferuloylmethane, Maltodextrin, Dextran, Hydroxyethylcellulose, Cetearyl Olivate, Sorbitan Olivate, Xanthan Gum, Isosorbide Dicaprylate
Isononyl Isononanoate
C12-15 Alkyl Benzoate
Butylene Glycol
Polysorbate 60
Tetrahexyldecyl Ascorbate
Marrubium Vulgare Extract
Palmitoyl Tripeptide-5
Acetyl Tetrapeptide-40
Hydrolyzed Verbascum Thapsus Flower
Teprenone
Astaxanthin
Euterpe Oleracea Fruit Oil
Rubus Idaeus Seed Oil
Honey
Dimethyl Isosorbide
Phenyl T-Butylnitrone
Glutathione
Ergothioneine
Caprylyl Glycol
Carbomer
Benzimidazole Diamond Amidoethyl Urea Carbamoyl Propyl Polymethylsilsesquioxane
Mica
Citric Acid
Sodium Hydroxide
CI 77891
Ethylhexylglycerin
Isohexadecane
Polysorbate 80
Acetyl Tributyl Citrate
Tetrasodium EDTA
Sorbitan Oleate
Sodium Benzoate
Potassium Sorbate
Sodium Glycolate
Polysorbate 20
Phenoxyethanol
O-Cymen-5-Ol
Water, Glycerin, Caprylic/Capric Triglyceride, Isononyl Isononanoate, Caffeine, C12-15 Alkyl Benzoate, Niacinamide, Lactobacillus Ferment, Cetearyl Olivate, Butylene Glycol, Polysorbate 60, Tetrahexyldecyl Ascorbate, Marrubium Vulgare Extract, Plantago Lanceolata Leaf Extract, Palmitoyl Tripeptide-5, Acetyl Tetrapeptide-40, Palmitoyl Tripeptide-8, Hydrolyzed Verbascum Thapsus Flower, Moringa Oleifera Seed Extract, Teprenone, Phospholipids, Hyaluronic Acid, Syringa Vulgaris Leaf Cell Culture Extract, Sphingolipids, Astaxanthin, Bisabolol, Euterpe Oleracea Fruit Oil, Rubus Idaeus Seed Oil, Honey, Dimethyl Isosorbide, Ceramide NP, Phenyl T-Butylnitrone, Tocopherol, Glutathione, Tetrahydrodiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrobisdemethoxydiferuloylmethane, Ergothioneine, Xanthan Gum, Caprylyl Glycol, Carbomer, Sorbitan Olivate, Benzimidazole Diamond Amidoethyl Urea Carbamoyl Propyl Polymethylsilsesquioxane, Mica, Dextran, Citric Acid, Sodium Hydroxide, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, CI 77891, Ethylhexylglycerin, Isohexadecane, Maltodextrin, Polysorbate 80, Acetyl Tributyl Citrate, Tetrasodium EDTA, Sorbitan Oleate, Sodium Benzoate, Potassium Sorbate, Sodium Glycolate, Polysorbate 20, Phenoxyethanol, O-Cymen-5-Ol
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
This ingredient is a synthetic polymer used to stabilize formulas and give products a "gel-cream" feel.
When applied, this ingredient mostly stays on the surface of skin. Safety reviews have found these polymers safe in cosmetics when made to proper quality standards. Testing also shows they’re unlikely to cause irritation or sensitization at normal use levels.
Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.
It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.
A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.
In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.
You'll likely see use concentrations quite low, usually 0.1-0.2%.
Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.
Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.
As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.
Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.
You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.
Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.
Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.
Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.
This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.
A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.
Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.
Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.
Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.
Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.
You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.
These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.
This ingredient is well-tolerated and has no significant sensitization data.
Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.
Dextran is a sugar (polysaccharide) with skin hydrating properties.
Fun fact: Louis Pasteur first discovered this ingredient as a microbial product in wine.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
This ingredient is made when the Lactobacillus bacteria (the same kind that makes yogurt and kimchi) are allowed to ferment a nutrient medium.
As it ferments, it collects lactic acid, peptides, enzymes, and other bioactive metabolites to provide:
A 2023 review noted that probiotic fermentation ingredients like this one can enhance antioxidant capacity, reduce UV-induced oxidative damage, and support barrier function.
One clinical study from the same year showed a Lactobacillus ferment lysate significantly reduced transepidermal water loss and improved skin hydration.
Another review highlighted that topical Lactobacillus-based preparations can improve ceramide levels in the stratum corneum, support barrier integrity, and even help reduce S. aureus colonization in atopic dermatitis.
Why is this so cool?
Basically, your skin's outer layer works as a brick wall; skin cells are bricks and ceramides are the mortar holding it together. Moisture escapes, irritants get in, and your skin gets dry and reactive when ceramide levels drop. On top of that, "bad" skin bacteria S. aureus loves to move in when your barrier is weak to make inflammation and irritation worse.
So Lactobacillus ferment is basically patching the wall and evicting the troublemaker when it boosts ceramide production and help keep S. aureus in check.
On top of all this, it also acts as a mild antimicrobial preservative booster.
Just so you know, most studies focus on specific strains or the lysate form rather than this generic "Lactobacillus Ferment", so results can vary.
Though it's a promising ingredient, it doesn't have decades of robust clinical data behind it just yet.
Lactobacillus Ferment is generally considered safe for fungal-acne prone skin. The key thing to understand is that it comes from bacteria, not yeast or fungus.
Yeast-derived ferments (like galactomyces) have been shown to activate a protein that's linked to Malassezia-related skin issues whereas lactobacillus doesn't have that problem.
Its byproducts also don't contain the types of fatty acids (C11-24 chain lengths) that Malassezia feeds on.
Maltodextrin is a plant-derived carbohydrate made by breaking down starch (usually from corn, potato, or rice). In cosmetic formulas, it's a multitasking absorbent, emulsion stabilizer, and skin conditioner.
This ingredient is mostly used to stabilize emulsions and improve the powdery, non-greasy feel of products (like dry shampoos).
Safety-wise, this ingredient is pretty solid; it's even recognized as a food additive. Both animal and clinical studies found no adverse effects at the levels used in cosmetics.
Industry data shows this ingredient is used up to 45.7% in spray products and up to 33% in powder products.
Moringa Oleifera Seed Extract comes from the seeds of the Moringa oleifera plant.
Moringa seeds have antioxidant, anti-inflammatory, and skin hydrating properties. These seeds are rich in oils, proteins, monounsaturated fats, and tocopherols.
As an emollient, moringa seed oil helps trap moisture in the skin by creating a film on top. This helps keep your skin hydrated and soft.
Many compounds in moringa seed oil are antioxidant and anti-inflammatory. These compounds include Vitamin E. , catechins, ferulic acid, and more.
Another compound found in Moringa seed oil is oleic acid.
Moringa trees are native to the Himalayan mountains.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
This synthetic peptide is created from palmitic acid, arginine, histidine, and phenylalanine.
According to the manufacturer, this peptide is great at soothing skin inflammation.
Phospholipids are a family of skin-identical lipids that makeup the structural backbone of every cell membrane in your body.
In cosmetics, they function as skin conditioning agents with emulsifier and surfactant properties. They're typically sourced from soybean or sunflower lecithin (or sometimes egg yolk or marine sources).
Because they mirror the lipids naturally found in the deeper layers of your skin, topical phospholipids help reinforce the lipid matrix, reduce transepidermal water loss, and leave skin feeling conditioned.
They're also used to form liposomes, or tiny self-assembling vesible used to stabilize actives like vitamin c or retinol. This helps these ingredients integrate into the upper layers of skin more easily.
Phospholipids are compatible with everything and the CIR Expert Panel has concluded them to be safe at current use levels.
Some types of phospholipids include:
We don't have a description for Plantago Lanceolata Leaf Extract yet.
Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.
This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.
This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.
According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.
Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.
Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.
Sphingolipids are a major class of lipids in cell membranes. This ingredient has emollient, skin conditioning, and skin protecting properties.
Certain ceramides are considered sphingolipids (Ceramide NS and Ceramid AP), but not all sphingolipids are ceramides.
We don't have a description for Syringa Vulgaris Leaf Cell Culture Extract yet.
Tetrahydrobisdemethoxydiferuloylmethane is an antioxidant.
Tetrahydrodemethoxydiferuloylmethane is an antioxidant.
Tetrahydrodiferuloylmethane is an antioxidant.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.