Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Anua Heartleaf 80% Soothing Ampoule Versus Beauty of Joseon Calming Serum: Green Tea + Panthenol

Anua Heartleaf 80% Soothing Ampoule Versus Beauty of Joseon Calming Serum: Green Tea + Panthenol This calming ampoule is formulated around Houttuynia Cordata Extract and Panthenol to calm redness and hydrate skin. This calming serum is formulated around Panthe

Anua Heartleaf 80% Soothing Ampoule Versus Beauty of Joseon Calming Serum: Green Tea + Panthenol

This calming ampoule is formulated around Houttuynia Cordata Extract and Panthenol to calm redness and hydrate skin.

This calming serum is formulated around Panthenol and Dipotassium Glycyrrhizate to calm redness and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Ingredients Side-by-side

Houttuynia Cordata Extract

Butylene Glycol

Glycerin

1,2-Hexanediol

Betaine

Cassia Obtusifolia Seed Extract

Panthenol

Hydroxyethylcellulose

Sodium Hyaluronate

Arginine

Carbomer

Ethylhexylglycerin

Houttuynia Cordata Extract, Butylene Glycol, Glycerin, 1,2-Hexanediol, Betaine, Cassia Obtusifolia Seed Extract, Panthenol, Hydroxyethylcellulose, Sodium Hyaluronate, Arginine, Carbomer, Ethylhexylglycerin

Water

Methylpropanediol

Camellia Sinensis Leaf Water

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Allantoin

Dipotassium Glycyrrhizate

Artemisia Capillaris Extract

Glyceryl Acrylate/Acrylic Acid Copolymer

Melia Azadirachta Leaf Extract

Polyquaternium-51

Malt Extract

Melia Azadirachta Flower Extract

Coptis Japonica Root Extract

Water, Panthenol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Methylpropanediol, Camellia Sinensis Leaf Water, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Betaine, Ethylhexylglycerin, Allantoin, Dipotassium Glycyrrhizate, Artemisia Capillaris Extract, Glyceryl Acrylate/Acrylic Acid Copolymer, Melia Azadirachta Leaf Extract, Polyquaternium-51, Malt Extract, Melia Azadirachta Flower Extract, Coptis Japonica Root Extract, Sodium Hyaluronate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.

Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.

Some studies suggest betaine may support making skin tone more even.

Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.

Betaine is also known as trimethylglycine.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 031,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
  4. 04It is a:
  5. 05Humectant, drawing moisture into the skin
  6. 06Emollient, helping to soften skin
  7. 07Solvent, dispersing and stabilizing formulas
  8. 08Preservative booster, enhancing the antimicrobial activity of other preservatives
  9. 09Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
  10. 10The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure …
  11. 11Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
  12. 12Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
  13. 13And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
  14. 14You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
  15. 15In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
  16. 16If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
  17. 17When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
  18. 18When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
  19. 19In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
  20. 20Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger l…
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side