Skin science article
Avène RetrinAL EYES Versus Paula's Choice Ceramide-Enriched Firming Eye Cream
Avène RetrinAL EYES Versus Paula's Choice Ceramide-Enriched Firming Eye Cream This anti-aging eye moisturizer is formulated around Retinal and Sodium Hyaluronate to soften the look of wrinkles and refine skin texture. This anti-aging eye moisturizer is formula
Avène RetrinAL EYES Versus Paula's Choice Ceramide-Enriched Firming Eye Cream
This anti-aging eye moisturizer is formulated around Retinal and Sodium Hyaluronate to soften the look of wrinkles and refine skin texture.
This anti-aging eye moisturizer is formulated around Ceramide Ns and Palmitoyl Tripeptide-5 to soften the look of wrinkles and strengthen the skin barrier.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Aluminum Starch Octenylsuccinate
Glycerin
Isodecyl Neopentanoate
PPG-15 Stearyl Ether
Cetyl Alcohol
Cetearyl Alcohol
Glyceryl Stearate
PEG-100 Stearate
Caprylic/Capric Triglyceride
Dimethicone
1,2-Hexanediol
Ascophyllum Nodosum Extract
BHT
Caprylyl Glycol
Ceteareth-33
Disodium EDTA
Retinal
Sodium Dextran Sulfate
Sodium Hyaluronate
Sodium Hydroxide
Tocopheryl Acetate
Xanthan Gum
Water, Aluminum Starch Octenylsuccinate, Glycerin, Isodecyl Neopentanoate, PPG-15 Stearyl Ether, Cetyl Alcohol, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Caprylic/Capric Triglyceride, Dimethicone, 1,2-Hexanediol, Ascophyllum Nodosum Extract, BHT, Caprylyl Glycol, Ceteareth-33, Disodium EDTA, Retinal, Sodium Dextran Sulfate, Sodium Hyaluronate, Sodium Hydroxide, Tocopheryl Acetate, Xanthan Gum
Neopentyl Glycol Diheptanoate
Butylene Glycol
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Ascorbyl Glucoside
Potassium Cetyl Phosphate
Sodium Ascorbyl Phosphate
Bis-Diglyceryl Polyacyladipate-2
Polyglyceryl-10 Dioleate
Tetrahexyldecyl Ascorbate
Ceramide Ns
Ceramide EOP
Ceramide AP
Ceramide Eos
Ceramide NP
Palmitoyl Tripeptide-5
Acetyl Tetrapeptide-5
Caprooyl Phytosphingosine
Caprooyl Sphingosine
Cholesterol
Squalane
Retinol
Vitis Vinifera Seed Extract
Glycyrrhiza Glabra Root Extract
Punica Granatum Fruit Extract
Dunaliella Salina Extract
Pongamia Glabra Seed Oil
Allantoin
Bisabolol
Carnosine
Panthenol
Sodium PCA
Pullulan
Glyceryl Ascorbate
Behenic Acid
Sodium Citrate
Sodium Polyacrylate
Ethylhexyl Stearate
Ceteareth-25
Trideceth-6
Propyl Gallate
Polysorbate 20
Mica
Phenoxyethanol
Chlorphenesin
Sodium Benzoate
Water, Neopentyl Glycol Diheptanoate, Cetyl Alcohol, Butylene Glycol, Glycerin, Glyceryl Stearate, PEG-100 Stearate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Ascorbyl Glucoside, Potassium Cetyl Phosphate, Sodium Ascorbyl Phosphate, Bis-Diglyceryl Polyacyladipate-2, Polyglyceryl-10 Dioleate, Tetrahexyldecyl Ascorbate, Ceramide Ns, Ceramide EOP, Ceramide AP, Ceramide Eos, Ceramide NP, Palmitoyl Tripeptide-5, Acetyl Tetrapeptide-5, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Cholesterol, Squalane, Retinol, Vitis Vinifera Seed Extract, Glycyrrhiza Glabra Root Extract, Punica Granatum Fruit Extract, Dunaliella Salina Extract, Pongamia Glabra Seed Oil, Tocopheryl Acetate, Allantoin, Bisabolol, Carnosine, Panthenol, Sodium PCA, Pullulan, Glyceryl Ascorbate, Behenic Acid, Dimethicone, Sodium Citrate, Sodium Polyacrylate, Caprylyl Glycol, Ethylhexyl Stearate, Ceteareth-25, Sodium Hydroxide, Trideceth-6, Propyl Gallate, Polysorbate 20, Disodium EDTA, Mica, Phenoxyethanol, Chlorphenesin, Sodium Benzoate
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Peg-100 Stearate is an emollient and emulsifier. As an emollient, it helps keep skin soft by trapping moisture in. On the other hand, emulsifiers help prevent oil and water from separating in a product.
PEGS are a hydrophilic polyether compound . There are 100 ethylene oxide monomers in Peg-100 Stearate. Peg-100 Stearate is polyethylene glycol ester of stearic acid.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.
Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.
It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.
One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.
Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.
Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.
The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.
Most leave-on skincare keeps it at the lower end, often between 0.5-1%.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!