Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Beauty of Joseon Revive Eye Serum : Ginseng + Retinal Versus Celimax The Vita-A Retinal Shot Tightening Booster

Beauty of Joseon Revive Eye Serum : Ginseng + Retinal Versus Celimax The Vita-A Retinal Shot Tightening Booster This anti-aging eye moisturizer is formulated around Panax Ginseng Root Extract and Niacinamide to soften the look of wrinkles and refine skin textu

Beauty of Joseon Revive Eye Serum : Ginseng + Retinal Versus Celimax The Vita-A Retinal Shot Tightening Booster

This anti-aging eye moisturizer is formulated around Panax Ginseng Root Extract and Niacinamide to soften the look of wrinkles and refine skin texture.

This anti-aging treatment is formulated around Niacinamide and Retinal to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Panax Ginseng Root Extract

Glycerin

Dipropylene Glycol

Caprylic/Capric Triglyceride

1,2-Hexanediol

Pentaerythrityl Tetraethylhexanoate

Niacinamide

Butylene Glycol Dicaprylate/Dicaprate

Cetearyl Alcohol

Sorbitan Olivate

Cetearyl Olivate

Butylene Glycol

Hydrogenated Lecithin

Tromethamine

Carbomer

Glyceryl Stearate

Macadamia Ternifolia Seed Oil

Adenosine

Theobroma Cacao Extract

Dextrin

Cholesterol

Polyglyceryl-10 Oleate

Retinal

Brassica Campestris Sterols

Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate

Silica

Sodium Hyaluronate

Tocopherol

Aluminum/Magnesium Hydroxide Stearate

Potassium Cetyl Phosphate

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Ceramide NP

Palmitoyl Tripeptide-5

Disodium EDTA

Ethylhexylglycerin

Water, Panax Ginseng Root Extract, Glycerin, Dipropylene Glycol, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Pentaerythrityl Tetraethylhexanoate, Niacinamide, Butylene Glycol Dicaprylate/Dicaprate, Cetearyl Alcohol, Sorbitan Olivate, Cetearyl Olivate, Butylene Glycol, Hydrogenated Lecithin, Tromethamine, Carbomer, Glyceryl Stearate, Macadamia Ternifolia Seed Oil, Adenosine, Theobroma Cacao Extract, Dextrin, Cholesterol, Polyglyceryl-10 Oleate, Retinal, Brassica Campestris Sterols, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Silica, Sodium Hyaluronate, Tocopherol, Aluminum/Magnesium Hydroxide Stearate, Potassium Cetyl Phosphate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Ceramide NP, Palmitoyl Tripeptide-5, Disodium EDTA, Ethylhexylglycerin

Diisostearyl Malate

Polypropylsilsesquioxane

Panthenol

Cetearyl Glucoside

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Lecithin

Arginine

Dimethicone/Vinyl Dimethicone Crosspolymer

Retinal 0.1%

Xanthan Gum

Sorbitan Isostearate

Sodium Lactate

Hydrolyzed Sponge

Polysorbate 20

Ascorbic Acid

Glucose

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Water, Butylene Glycol, Glycerin, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Niacinamide, Diisostearyl Malate, 1,2-Hexanediol, Polypropylsilsesquioxane, Panthenol, Cetearyl Olivate, Cetearyl Glucoside, Sorbitan Olivate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Carbomer, Arginine, Dimethicone/Vinyl Dimethicone Crosspolymer, Tocopherol, Retinal 0.1%, Xanthan Gum, Ethylhexylglycerin, Adenosine, Sorbitan Isostearate, Sodium Lactate, Hydrolyzed Sponge, Disodium EDTA, Polysorbate 20, Ascorbic Acid, Glucose, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.

You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.

These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.

This ingredient is well-tolerated and has no significant sensitization data.

Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Retinal (aka retinaldehyde) is a form of retinoid that formulators use mainly as an antiaging and skin-renewing active.

What makes it special is its position in the retinoid family; skin converts it to retinoic acid (the prescription gold standard) in just one step.

Because retinal only requires 1 conversion step to become retinoic acid, it's the strongest over-the-counter retinoid. It also works at lower concentrations than retinol, since retinal is about 10x more bioavailable.

Studies back up its efficacy in skin:

A foundational trial showed that applying 0.05-0.5% retinal for 1-3 months produced a dose-dependent and significant increase in epidermal thickness + cell turnover markers.

And a head-to-head comparison of 0.05% retinal against a 0.05% retinoid acid found both formulations were effective for the basis of wrinkle/skin roughness features, but retinoic acid caused more local irritation.

More recent controlled trials confirm it improves wrinkles, dermal density, and firmness over 12-24 weeks, with significant improvements in skin texture and firmness (particularly with the higher 0.1% concentration).

Retinal also has one trick the other retinoids do not: it directly fights against acne bacteria since a clinical study showed retinaldehyde-treated areas displayed a significant decrease in counts of viable P. acnes.

This makes it a great pick for people who want to treat aging and breakouts.

Typical cosmetic use sits in the 0.05-0.1% range with 0.05% being the gentle starting point and 0.1% giving stronger results.

Like all retinoids, retinal works best with nightly use, a good moisturizer, and daytime sunscreen. It can cause some irritation so ease into it slowly rather than going all in.

The "ramp up" method works well: start with Retinal once a week to give your skin time to adjust, which keeps irritation low.

Slowly add more nights until you reach your goal frequency once your skin feels comfortable.

Retinoids also make your skin more sensitive to the sun in the first few weeks, so wear sunscreen every morning and protect your skin from direct sun while you build up tolerance.

Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.

This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.

This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.

According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.

Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.

Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01Glycine Soja Oil is a plant-derived oil from soybean seeds. Like other oils, it is rich in essential fatty acids (mostly linoleic and oleic) that support skin hydration and barrier function.
  2. 02The fatty acids are able to integrate into the lipid matrix of the stratum corneum to help soften skin and reduce water loss.
  3. 03On top of that, soybean oil is rich in vitamins like vitamin E, a potent antioxidant.
  4. 04Research on soybean's active components also point to anti-inflammatory, collagen-stimulating, antioxidant activity, and protection against UV-induced oxidative damage.
  5. 05Most of this research applies to the broader soybean plant and not just the oil fraction alone.
  6. 06This ingredient may not be fungal acne safe due to the oleic acid content.
  7. 07Cetyl Ethylhexanoate is an emollient ester. It comes from cetearyl alcohol and 2-ethylhexanoic acid.
  8. 08Cetyl Ethylhexanoate is an emollient that adds a velvety feel to skin without being greasy or oily. Emollients help trap moisture into your skin, keeping your skin soft and hydrated.
  9. 09Sorbeth-30 Tetraoleate is a surfactant and emulsifier.
  10. 10This ingredient is a tetraester from oleic acid and polyethylene glycol ether of sorbitol.
  11. 11As an emulsifier, it helps ingredients such as oil and water mix together. This allows the dirt and oils in your skin to be washed away.
  12. 12One study found pumpkin oil containing Sorbeth-30 Tetraoleate helped hydrate the skin and did not cause any irritation.
  13. 13Isododecane is a fragrance, emollient, and solvent.
  14. 14As an emollient, it helps your skin stay soft and hydrated. Emollients help trap moisture into your skin.
  15. 15Isododecane's role as a solvent makes it a great texture enhancer. It spreads smoothly on skin and does not leave a sticky feeling behind. Isododecane also helps prevent color transfer in makeup products.
  16. 16Isododecane is not absorbed into skin.
  17. 17The chemical name for this ingredient is 2,2,4,6,6-PENTAMETHYLHEPTANE.
  18. 18This ingredient is also known as olive oil. It has been used in skincare for centuries and science largely backs up its reputation as a nourishing emollient.
  19. 19The main components of olive oil are oleic acid (55-83%), linoleic acid (3.5-20%), and palmitic acid (7-20%). Oleic acid promotes skin regeneration and helps regulate inflammatory responses.
  20. 20Squalene is also naturally present in olive oil and exhibits moisturizing and antioxidant properties.
Source · skinsort.com
02

Product index

Related product references

Product

Beauty of Joseon Dynasty Cream

Beauty of Joseon Dynasty Cream Beauty of Joseon Dynasty Cream ingredients explained: Water, Butylene Glycol, Niacinamide, Dipentaerythrityl Hexa C5-9 Acid Esters, Hyaluronic Acid, Xanthan G…

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side