Skin science article
CeraVe Skin Renewing Night Cream Versus Paula's Choice Skin Recovery Replenishing Moisturizer
CeraVe Skin Renewing Night Cream Versus Paula's Choice Skin Recovery Replenishing Moisturizer This barrier-repair night moisturizer is formulated around Ceramide NP and Niacinamide to strengthen the skin barrier and soften the look of wrinkles. This barrier-re
CeraVe Skin Renewing Night Cream Versus Paula's Choice Skin Recovery Replenishing Moisturizer
This barrier-repair night moisturizer is formulated around Ceramide NP and Niacinamide to strengthen the skin barrier and soften the look of wrinkles.
This barrier-repair moisturizer is formulated around Oenothera Biennis Oil and Panthenol to strengthen the skin barrier and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Caprylic/Capric Triglyceride
Butyrospermum Parkii Butter
Dimethicone/Vinyl Dimethicone Crosspolymer
Cyclopentasiloxane
Glyceryl Stearate Se
Cetyl Alcohol
Dimethicone
Saccharide Isomerate
Stearic Acid
Palmitic Acid
Glycine Soja Sterols
Allantoin
Ceramide NP
Ceramide AP
Ceramide EOP
Carbomer
Niacinamide
Cetearyl Alcohol
Behentrimonium Methosulfate
Sodium Hydroxide
Myristic Acid
Sodium Lauroyl Lactylate
Sodium Benzoate
Sodium Citrate
Sodium Hyaluronate
Cholesterol
Phenoxyethanol
Tocopherol
Tripeptide-1
Laureth-9
Citric Acid
Caprooyl Tetrapeptide-3
Biosaccharide Gum-1
Phytosphingosine
Xanthan Gum
Dextran
Ethylhexylglycerin
Butylene Glycol
Water, Glycerin, Caprylic/Capric Triglyceride, Butyrospermum Parkii Butter, Dimethicone/Vinyl Dimethicone Crosspolymer, Cyclopentasiloxane, Glyceryl Stearate Se, Cetyl Alcohol, Dimethicone, Saccharide Isomerate, Stearic Acid, Palmitic Acid, Glycine Soja Sterols, Allantoin, Ceramide NP, Ceramide AP, Ceramide EOP, Carbomer, Niacinamide, Cetearyl Alcohol, Behentrimonium Methosulfate, Sodium Hydroxide, Myristic Acid, Sodium Lauroyl Lactylate, Sodium Benzoate, Sodium Citrate, Sodium Hyaluronate, Cholesterol, Phenoxyethanol, Tocopherol, Tripeptide-1, Laureth-9, Citric Acid, Caprooyl Tetrapeptide-3, Biosaccharide Gum-1, Phytosphingosine, Xanthan Gum, Dextran, Ethylhexylglycerin, Butylene Glycol
Cetearyl Ethylhexanoate
Glycereth-26
Oenothera Biennis Oil
Neopentyl Glycol Diheptanoate
Glyceryl Stearate
PEG-100 Stearate
Cyclohexasiloxane
Panthenol
Palmitoyl Tripeptide-1
Palmitoyl Tetrapeptide-7
Tocopheryl Linoleate
Tocopheryl Acetate
Magnesium Ascorbyl Phosphate
Ascorbyl Palmitate
Dipotassium Glycyrrhizate
Sodium PCA
Anthemis Nobilis Flower Extract
Aloe Barbadensis Leaf Juice
Sodium Ascorbyl Phosphate
Linoleic Acid
Linolenic Acid
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Hydroxypropyl Guar
Rosa Moschata Seed Oil
Polysorbate 20
Cetyl Hydroxyethylcellulose
Trisodium EDTA
Batyl Alcohol
Chlorphenesin
Benzoic Acid
Sorbic Acid
Water, Cetearyl Ethylhexanoate, Butylene Glycol, Glycereth-26, Oenothera Biennis Oil, Cetyl Alcohol, Neopentyl Glycol Diheptanoate, Cyclopentasiloxane, Stearic Acid, Glyceryl Stearate, PEG-100 Stearate, Glycerin, Cyclohexasiloxane, Dimethicone, Panthenol, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Sodium Hyaluronate, Tocopheryl Linoleate, Tocopheryl Acetate, Tocopherol, Magnesium Ascorbyl Phosphate, Ascorbyl Palmitate, Dipotassium Glycyrrhizate, Sodium PCA, Anthemis Nobilis Flower Extract, Aloe Barbadensis Leaf Juice, Sodium Ascorbyl Phosphate, Linoleic Acid, Linolenic Acid, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Saccharide Isomerate, Hydroxypropyl Guar, Allantoin, Rosa Moschata Seed Oil, Polysorbate 20, Cetyl Hydroxyethylcellulose, Carbomer, Sodium Citrate, Trisodium EDTA, Batyl Alcohol, Sodium Hydroxide, Phenoxyethanol, Chlorphenesin, Benzoic Acid, Sorbic Acid
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.
Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.
Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.
It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.
Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.
This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.
Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.
Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
Cyclopentasiloxane (D5) is a lightweight silicone that mostly acts as an emollient and solvent in cosmetics. Its the reason your products feel silky, fast-spreading, and non-greasy.
Since D5 is volatile, it does its thing and then evaporates off the skin quickly.
The safety profile of this ingredient is reassuring; the US CIR Expert Panel concluded D5 is safe as used in cosmetics and Health Canada concluded that D5 is not harmful to human health or the environment as currently used in cosmetics
There's a study that people mention about D5 in a rat study showing tumors. This study is related to long-term inhalation of high D5 levels.
Regulatory bodies have judged this study to be not applicable in topical skincare since skin absorption of D5 is very low and we're not really inhaling huge amounts of D5.
The only restriction for this ingredient is environmental. The European Chemicals Agency (ECHA) restricted D5 in wash-off cosmetics at or above 0.1% due to their persistence in water.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Saccharide Isomerate comes from sugars found in corn. It is a skin hydrator.
The structure of this ingredient can be altered to be more similar to the carbohydrates found in our skin. This ability to mimic our skin gives it hydrating properties.
Specifically, saccharide Isomerate is a humectant. Humectants draw moisture from the air to our skin.
Research shows Saccharide Isomerate to be an effective moisturizer.
Sodium Citrate is the sodium salts of citric acid. In skincare, it is used to alter pH levels and acts as a preservative.
Its main functions are to maintain the pH of a product and neutralize metal ions.
The acidity of our skin is maintained by our glands and skin biome; normal pH level of skin is slightly acidic (~4.75-5.5).
Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Stearic Acid is a fatty acid that is already found in your skin. It's one of the free fatty acids that works alongside ceramides and cholesterols to maintain your barrier.
In cosmetics, it is a multitasker:
Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.
Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!