Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Cetaphil Rich Hydrating Cream Versus Olay Regenerist Retinol 24 + Peptide Night Moisturizer

Cetaphil Rich Hydrating Cream Versus Olay Regenerist Retinol 24 + Peptide Night Moisturizer This barrier-repair moisturizer is formulated around Caprylic/Capric Triglyceride and Hydrolyzed Hyaluronic Acid to strengthen the skin barrier and hydrate skin. This a

Cetaphil Rich Hydrating Cream Versus Olay Regenerist Retinol 24 + Peptide Night Moisturizer

This barrier-repair moisturizer is formulated around Caprylic/Capric Triglyceride and Hydrolyzed Hyaluronic Acid to strengthen the skin barrier and hydrate skin.

This anti-aging night moisturizer is formulated around Retinol and Niacinamide to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Hydrogenated Polydecene

Caprylic/Capric Triglyceride

Dimethicone

Glycerin

Butylene Glycol

Cetearyl Olivate

Sorbitan Olivate

Cyclopentasiloxane

Marrubium Vulgare Extract

Hydrolyzed Hyaluronic Acid

Olea Europaea Fruit Oil

Tocopheryl Acetate

Ascorbyl Palmitate

Leuconostoc/Radish Root Ferment Filtrate

Phospholipids

Isopropyl Lauroyl Sarcosinate

Cetearyl Alcohol

Sodium Polyacrylate

1,2-Hexanediol

Caprylyl Glycol

Polymethylsilsesquioxane

Isohexadecane

Glyceryl Stearate

PEG-100 Stearate

Cetearyl Methicone

Phenoxyethanol

PEG-40 Stearate

Steareth-2

Steareth-21

Retinyl Palmitate

Linoleic Acid

Lycopene

Water, Hydrogenated Polydecene, Caprylic/Capric Triglyceride, Dimethicone, Glycerin, Butylene Glycol, Cetearyl Olivate, Sorbitan Olivate, Cyclopentasiloxane, Marrubium Vulgare Extract, Hydrolyzed Hyaluronic Acid, Olea Europaea Fruit Oil, Tocopheryl Acetate, Ascorbyl Palmitate, Leuconostoc/Radish Root Ferment Filtrate, Phospholipids, Isopropyl Lauroyl Sarcosinate, Cetearyl Alcohol, Sodium Polyacrylate, 1,2-Hexanediol, Caprylyl Glycol, Polymethylsilsesquioxane, Isohexadecane, Glyceryl Stearate, PEG-100 Stearate, Cetearyl Methicone, Phenoxyethanol, PEG-40 Stearate, Steareth-2, Steareth-21, Retinyl Palmitate, Linoleic Acid, Lycopene

Tapioca Starch

Dimethicone Crosspolymer

Retinol

Retinyl Propionate

Niacinamide

Palmitoyl Pentapeptide-4

Polyacrylamide

C13-14 Isoparaffin

DMDM Hydantoin

Polysorbate 20

Laureth-4

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Laureth-7

Dimethiconol

Aminomethyl Propanol

Titanium Dioxide

Disodium EDTA

Iodopropynyl Butylcarbamate

Water, Dimethicone, Glycerin, Tapioca Starch, Dimethicone Crosspolymer, Retinol, Retinyl Propionate, Niacinamide, Palmitoyl Pentapeptide-4, Polyacrylamide, C13-14 Isoparaffin, DMDM Hydantoin, Polysorbate 20, Laureth-4, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Laureth-7, Dimethiconol, Polymethylsilsesquioxane, Aminomethyl Propanol, Titanium Dioxide, Disodium EDTA, Iodopropynyl Butylcarbamate, Caprylic/Capric Triglyceride

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Polymethylsilsesquioxane is a silicone used as a film forming agent.

When applied to the skin, this ingredient creates an invisible film on the surface. This film still allows oxygen to pass through, but prevents moisture from escaping. This can help condition and hydrate the skin. It also leaves a silky feel when applied.

Polymethylsilsesquioxane has not been shown to clog pores. It has been deemed safe to use up to 55%, but most cosmetics use much less.

If you have concerns about using this ingredient, we recommend speaking with a professional.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
  4. 04Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
  5. 05In practice, that translates to a long shelf life and a consistently elegant skin feel.
  6. 06While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
  7. 07Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
  8. 08This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
  9. 09This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures…
  10. 10Dimethiconol is a silicone that resembles the popular dimethicone. Like other silicones, it is an emollient. Emollients create a thin film on skin to prevent moisture from escaping.
  11. 11This ingredient helps to create a silky texture and improve spreadability. Due to its high molecular weight and thickness, it is often combined with cyclopentasiloxane.
  12. 12Retinol is one of the most studied anti-aging ingredients in skincare (and for good reason!).
  13. 13It's a form of vitamin A that your skin converts into Retinoic Acid, the active molecule that actually does the work in your cells.
  14. 14That conversion happens in two steps: your skin first turns Retinol into Retinaldehyde (also called Retinal), then turns Retinaldehyde into Retinoic Acid.
  15. 15Retinol is converted to biologically active retinoic acid via retinaldehyde by dehydrogenases in a two-step oxidation process.
  16. 16Each step is a little "upgrade" toward the active form which is part of why Retinol is gentler than prescription Retinoic Acid; your skin does the work gradually. This also explains where Retinol sits in the retinoid family.
  17. 17Here is the retinoid family ranked roughly by strength: Retinyl Esters (like Retinyl Palmitate) < Retinol < Retinaldehyde < Retinoic Acid.
  18. 18Retinoid activity increases in that order, while tolerance runs in reverse; retinyl esters are the gentlest and retinoic acid the most irritating.
  19. 19The more conversion steps an ingredient needs, the gentler (and slower) it tends to be, so Retinol lands in a nice middle spot. It's more effective than the esters, gentler than prescription options.
  20. 20Once it becomes Retinoic Acid, it binds to receptors inside your cells' nuclei (called RARs and RXRs). These receptor pairs bind to specific DNA motifs called retinoic acid response elements and act like switches that turn certain genes on or off.
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side