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Skin science article

Clinique Clarifying Lotion 3 Versus Paula's Choice Resist Advanced Replenishing Toner

Clinique Clarifying Lotion 3 Versus Paula's Choice Resist Advanced Replenishing Toner This oil-control exfoliator is formulated around Salicylic Acid to balance excess oil and refine skin texture. This barrier-repair toner is formulated around Linoleic Acid an

Clinique Clarifying Lotion 3 Versus Paula's Choice Resist Advanced Replenishing Toner

This oil-control exfoliator is formulated around Salicylic Acid to balance excess oil and refine skin texture.

This barrier-repair toner is formulated around Linoleic Acid and Phospholipids to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Alcohol Denat.

Salicylic Acid

Hamamelis Virginiana Water

Butylene Glycol

Glycerin

Trehalose

Sodium Hyaluronate

Citric Acid

Sodium Hydroxide

Disodium EDTA

BHT

Phenoxyethanol

Benzophenone-4

Extracts

CI 60730

CI 15850

CI 15510

Water, Alcohol Denat., Salicylic Acid, Hamamelis Virginiana Water, Butylene Glycol, Glycerin, Trehalose, Sodium Hyaluronate, Citric Acid, Sodium Hydroxide, Disodium EDTA, BHT, Phenoxyethanol, Benzophenone-4, Extracts, CI 60730, CI 15850, CI 15510

Cyclopentasiloxane

Glycereth-26

Polysorbate 20

Dimethiconol

Linoleic Acid

Oleic Acid

Linolenic Acid

Phospholipids

Carnosine

Epigallocatechin Gallate

Genistein

Sphingolipids

Ferulic Acid

Laurdimonium Hydroxypropyl Hydrolyzed Soy Protein

Glycyrrhiza Glabra Root Extract

Acetyl Glucosamine

Quercetin

Oenothera Biennis Oil

Beta Vulgaris Root Extract

Cucurbita Pepo Seed Extract

Lecithin

Caprylic/Capric Triglyceride

Hydrolyzed Corn Starch

Hydrogenated Lecithin

Palmitic Acid

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Xanthan Gum

Laureth-23

Laureth-4

Aminomethyl Propanol

Sodium Benzoate

Ethylhexylglycerin

Chlorphenesin

Benzoic Acid

Sorbic Acid

Water, Cyclopentasiloxane, Glycerin, Glycereth-26, Polysorbate 20, Dimethiconol, Linoleic Acid, Oleic Acid, Linolenic Acid, Phospholipids, Carnosine, Epigallocatechin Gallate, Genistein, Sodium Hyaluronate, Sphingolipids, Ferulic Acid, Laurdimonium Hydroxypropyl Hydrolyzed Soy Protein, Glycyrrhiza Glabra Root Extract, Acetyl Glucosamine, Quercetin, Oenothera Biennis Oil, Beta Vulgaris Root Extract, Cucurbita Pepo Seed Extract, Lecithin, Caprylic/Capric Triglyceride, Hydrolyzed Corn Starch, Hydrogenated Lecithin, Palmitic Acid, Butylene Glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Laureth-23, Laureth-4, Aminomethyl Propanol, Disodium EDTA, Sodium Benzoate, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin, Benzoic Acid, Sorbic Acid

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

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Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  4. 04Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  5. 05Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  6. 06Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
  7. 07This ingredient mainly works behind the scenes and helps with:
  8. 08On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
  9. 09One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too st…
  10. 10Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
  11. 11You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
  12. 12Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
  13. 13So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
  14. 14You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Source · skinsort.com
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Product index

Related product references

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Comparison edit

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