Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Clinique Dramatically Different Moisturizing Cream Versus Olehenriksen Strength Trainer Peptide Boost Moisturizer

Clinique Dramatically Different Moisturizing Cream Versus Olehenriksen Strength Trainer Peptide Boost Moisturizer This moisturizer is formulated around Petrolatum and Cucumis Sativus Fruit Extract to hydrate skin. This barrier-repair moisturizer is formulated

Clinique Dramatically Different Moisturizing Cream Versus Olehenriksen Strength Trainer Peptide Boost Moisturizer

This moisturizer is formulated around Petrolatum and Cucumis Sativus Fruit Extract to hydrate skin.

This barrier-repair moisturizer is formulated around Niacinamide and Acetyl Hexapeptide-8 to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dimethicone

Petrolatum

Tridecyl Stearate

Tridecyl Trimellitate

Polyglyceryl-10 Pentastearate

Behenyl Alcohol

Dipentaerythrityl Hexacaprylate/Hexacaprate

Cucumis Sativus Fruit Extract

Hordeum Vulgare Extract

Sodium Stearoyl Lactylate

Caprylyl Glycol

Propylene Glycol Dicaprate

Helianthus Annuus Seedcake

PEG-100 Stearate

Sodium Hyaluronate

Cetyl Alcohol

Butylene Glycol

Tromethamine

Carbomer

Phenoxyethanol

CI 19140

CI 15985

CI 17200

Water, Glycerin, Dimethicone, Petrolatum, Tridecyl Stearate, Tridecyl Trimellitate, Polyglyceryl-10 Pentastearate, Behenyl Alcohol, Dipentaerythrityl Hexacaprylate/Hexacaprate, Cucumis Sativus Fruit Extract, Hordeum Vulgare Extract, Sodium Stearoyl Lactylate, Caprylyl Glycol, Propylene Glycol Dicaprate, Helianthus Annuus Seedcake, PEG-100 Stearate, Sodium Hyaluronate, Cetyl Alcohol, Butylene Glycol, Tromethamine, Carbomer, Phenoxyethanol, CI 19140, CI 15985, CI 17200

Propanediol

Dicaprylyl Carbonate

Methylpropanediol

Cetearyl Alcohol

Stearyl Alcohol

Mangifera Indica Seed Butter

Niacinamide

Acetyl Hexapeptide-1

Acetyl Hexapeptide-8

Acetyl Octapeptide-3

Acetyl Tetrapeptide-2

Acetyl Dipeptide-1 Cetyl Ester

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Carnosine

Ceramide NP

Ceramide AP

Ceramide EOP

Collagen

Serine

Alanine

Glycine

Glutamic Acid

Lysine Hcl

Threonine

Arginine

Proline

Hyaluronic Acid

Linoleic Acid

Linolenic Acid

Sodium PCA

Sodium Lactate

Panthenol

Tocopherol

Tocopheryl Acetate

Betaine

PCA

Cyanocobalamin

Xylitol

Anhydroxylitol

Xylitylglucoside

Sorbitan Olivate

Hydroxyethylcellulose

Xanthan Gum

Cetearyl Olivate

Sorbitan Laurate

Phytosphingosine

Cholesterol

Polysorbate 60

Hydroxyacetophenone

Glycine Soja Oil

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Polysorbate 20

Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer

Sodium Phytate

Sodium Lauroyl Lactylate

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Leuconostoc/Radish Root Ferment Filtrate

Citric Acid

Ethylhexylglycerin

Parfum

Citral

Limonene

Linalool

Water, Propanediol, Dicaprylyl Carbonate, Glycerin, Methylpropanediol, Cetearyl Alcohol, Stearyl Alcohol, Mangifera Indica Seed Butter, Niacinamide, Acetyl Hexapeptide-1, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Acetyl Tetrapeptide-2, Acetyl Dipeptide-1 Cetyl Ester, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Carnosine, Ceramide NP, Ceramide AP, Ceramide EOP, Collagen, Serine, Alanine, Glycine, Glutamic Acid, Lysine Hcl, Threonine, Arginine, Proline, Hyaluronic Acid, Sodium Hyaluronate, Linoleic Acid, Linolenic Acid, Sodium PCA, Sodium Lactate, Panthenol, Tocopherol, Tocopheryl Acetate, Betaine, PCA, Cyanocobalamin, Xylitol, Anhydroxylitol, Xylitylglucoside, Sorbitan Olivate, Carbomer, Hydroxyethylcellulose, Xanthan Gum, Cetearyl Olivate, Sorbitan Laurate, Phytosphingosine, Cholesterol, Polysorbate 60, Butylene Glycol, Hydroxyacetophenone, Glycine Soja Oil, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Polysorbate 20, Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer, Dimethicone, Sodium Phytate, Sodium Lauroyl Lactylate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Leuconostoc/Radish Root Ferment Filtrate, Citric Acid, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Parfum, Citral, Limonene, Linalool

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

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Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  4. 04Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  5. 05Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  6. 06Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
  7. 07Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
  8. 08It plays several roles in a formula:
  9. 09Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
  10. 10Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
  11. 11However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
  12. 12Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
  13. 13Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
  14. 14Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
  15. 15This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
  16. 16A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
  17. 17Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
  18. 18Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
  19. 19However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
  20. 20Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
Source · skinsort.com
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