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Coxir Intensive EGF Peptide Cream Versus CeraVe Skin Renewing Night Cream

Coxir Intensive EGF Peptide Cream Versus CeraVe Skin Renewing Night Cream This anti-aging moisturizer is formulated around Niacinamide and Sh-Oligopeptide-1 to soften the look of wrinkles. This barrier-repair night moisturizer is formulated around Ceramide NP

Coxir Intensive EGF Peptide Cream Versus CeraVe Skin Renewing Night Cream

This anti-aging moisturizer is formulated around Niacinamide and Sh-Oligopeptide-1 to soften the look of wrinkles.

This barrier-repair night moisturizer is formulated around Ceramide NP and Niacinamide to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Glyceryl Acrylate/Acrylic Acid Copolymer

Propylene Glycol

Butylene Glycol Dicaprylate/Dicaprate

Dimethicone/Vinyl Dimethicone Crosspolymer

Methyl Gluceth-20

Niacinamide

1,2-Hexanediol

Betaine

Diisostearyl Malate

Cyclomethicone

PEG/PPG-18/4 Copolymer

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Isohexadecane

Polysorbate 80

Adenosine

Butylene Glycol

Hydrogenated Lecithin

Sh-Oligopeptide-1

Copper Tripeptide-1

Hydrogenated Vegetable Oil

Tri-C14-15 Alkyl Citrate

Myrciaria Dubia Fruit Extract

Malpighia Emarginata Fruit Extract

Tocopheryl Acetate

Arginine

Carbomer

Panthenol

Lonicera Japonica Flower Extract

Solanum Lycopersicum Fruit Extract

Lilium Tigrinum Extract

Nelumbo Nucifera Seed Extract

Chrysanthemum Indicum Flower Extract

Hydrolyzed Collagen

Acanthopanax Senticosus Root Extract

Punica Granatum Fruit Extract

Panax Ginseng Root Extract

Carthamus Tinctorius Flower Extract

Xanthan Gum

Malva Sylvestris Flower Extract

Buddleja Davidii Extract

Thymus Vulgaris Extract

Camellia Sinensis Callus Culture Extract

Phaseolus Radiatus Meristem Cell Culture Extract

Panax Ginseng Callus Culture Extract

Phenoxyethanol

Ethylhexylglycerin

Parfum

Water, Glycerin, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Butylene Glycol Dicaprylate/Dicaprate, Dimethicone/Vinyl Dimethicone Crosspolymer, Methyl Gluceth-20, Niacinamide, 1,2-Hexanediol, Betaine, Diisostearyl Malate, Cyclomethicone, PEG/PPG-18/4 Copolymer, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Polysorbate 80, Adenosine, Butylene Glycol, Hydrogenated Lecithin, Sh-Oligopeptide-1, Copper Tripeptide-1, Hydrogenated Vegetable Oil, Tri-C14-15 Alkyl Citrate, Myrciaria Dubia Fruit Extract, Malpighia Emarginata Fruit Extract, Tocopheryl Acetate, Arginine, Carbomer, Panthenol, Lonicera Japonica Flower Extract, Solanum Lycopersicum Fruit Extract, Lilium Tigrinum Extract, Nelumbo Nucifera Seed Extract, Chrysanthemum Indicum Flower Extract, Hydrolyzed Collagen, Acanthopanax Senticosus Root Extract, Punica Granatum Fruit Extract, Panax Ginseng Root Extract, Carthamus Tinctorius Flower Extract, Xanthan Gum, Malva Sylvestris Flower Extract, Buddleja Davidii Extract, Thymus Vulgaris Extract, Camellia Sinensis Callus Culture Extract, Phaseolus Radiatus Meristem Cell Culture Extract, Panax Ginseng Callus Culture Extract, Phenoxyethanol, Ethylhexylglycerin, Parfum

Caprylic/Capric Triglyceride

Butyrospermum Parkii Butter

Cyclopentasiloxane

Glyceryl Stearate Se

Cetyl Alcohol

Dimethicone

Saccharide Isomerate

Stearic Acid

Palmitic Acid

Glycine Soja Sterols

Allantoin

Ceramide NP

Ceramide AP

Ceramide EOP

Cetearyl Alcohol

Behentrimonium Methosulfate

Sodium Hydroxide

Myristic Acid

Sodium Lauroyl Lactylate

Sodium Benzoate

Sodium Citrate

Sodium Hyaluronate

Cholesterol

Tocopherol

Tripeptide-1

Laureth-9

Citric Acid

Caprooyl Tetrapeptide-3

Biosaccharide Gum-1

Phytosphingosine

Dextran

Water, Glycerin, Caprylic/Capric Triglyceride, Butyrospermum Parkii Butter, Dimethicone/Vinyl Dimethicone Crosspolymer, Cyclopentasiloxane, Glyceryl Stearate Se, Cetyl Alcohol, Dimethicone, Saccharide Isomerate, Stearic Acid, Palmitic Acid, Glycine Soja Sterols, Allantoin, Ceramide NP, Ceramide AP, Ceramide EOP, Carbomer, Niacinamide, Cetearyl Alcohol, Behentrimonium Methosulfate, Sodium Hydroxide, Myristic Acid, Sodium Lauroyl Lactylate, Sodium Benzoate, Sodium Citrate, Sodium Hyaluronate, Cholesterol, Phenoxyethanol, Tocopherol, Tripeptide-1, Laureth-9, Citric Acid, Caprooyl Tetrapeptide-3, Biosaccharide Gum-1, Phytosphingosine, Xanthan Gum, Dextran, Ethylhexylglycerin, Butylene Glycol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

This ingredient is a silicone elastomer that works as a texture enhancer, adds a silky slip, and also helps absorb excess oil.

Because it's a large macromolecule that's insoluble in water and chemically inert, it's not expected to penetrate or be absorbed into skin.

Human patch tests with a facial lotion containing 1% of this ingredient found no sensitization.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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The reference edit

Ingredients, questions
& further reading.

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Formula cabinet

Ingredients & structured notes

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Product index

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Comparison edit

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