Coxir Intensive EGF Peptides Serum Versus PURITO DermHA-3 Serum

Coxir Intensive EGF Peptides Serum Versus PURITO DermHA-3 Serum

This anti-aging serum is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture.

This hydrating serum is formulated around Sodium Hyaluronate and Panthenol to hydrate skin and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Butylene Glycol

Glycerin

1,2-Hexanediol

Niacinamide

Betaine

PEG/PPG-18/4 Copolymer

Acetyl Hexapeptide-8

Palmitoyl Pentapeptide-4

Tripeptide-1

Pentapeptide-13

Nonapeptide-1

Copper Tripeptide-1

Sh-Oligopeptide-1

Carbomer

Arginine

Allantoin

PPG-26-Buteth-26

PEG-40 Hydrogenated Castor Oil

Ethylhexylglycerin

Adenosine

Glyceryl Acrylate/Acrylic Acid Copolymer

Pvm/Ma Copolymer

Polyglyceryl-10 Laurate

Theobroma Cacao Extract

Pyrus Malus Leaf Extract

Vanilla Planifolia Fruit Extract

Caprylyl Glycol

Thymus Vulgaris Extract

Fragaria Chiloensis Fruit Extract

Camellia Sinensis Callus Culture Extract

Prunus Persica Fruit Extract

Musa Sapientum Fruit Extract

Bambusa Vulgaris Callus Culture Extract

Hydrogenated Lecithin

Leontopodium Alpinum Extract

Cocos Nucifera Oil

Prunus Domestica Fruit Extract

Hydrolyzed Collagen

Malva Sylvestris Flower Extract

Snail Secretion Filtrate

Tropolone

Water, Butylene Glycol, Glycerin, 1,2-Hexanediol, Niacinamide, Betaine, PEG/PPG-18/4 Copolymer, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Tripeptide-1, Pentapeptide-13, Nonapeptide-1, Copper Tripeptide-1, Sh-Oligopeptide-1, Carbomer, Arginine, Allantoin, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Adenosine, Glyceryl Acrylate/Acrylic Acid Copolymer, Pvm/Ma Copolymer, Polyglyceryl-10 Laurate, Theobroma Cacao Extract, Pyrus Malus Leaf Extract, Vanilla Planifolia Fruit Extract, Caprylyl Glycol, Thymus Vulgaris Extract, Fragaria Chiloensis Fruit Extract, Camellia Sinensis Callus Culture Extract, Prunus Persica Fruit Extract, Musa Sapientum Fruit Extract, Bambusa Vulgaris Callus Culture Extract, Hydrogenated Lecithin, Leontopodium Alpinum Extract, Cocos Nucifera Oil, Prunus Domestica Fruit Extract, Hydrolyzed Collagen, Malva Sylvestris Flower Extract, Snail Secretion Filtrate, Tropolone

Sodium Hyaluronate

Panthenol

Glyceryl Glucoside

Pentylene Glycol

Hydroxyethylcellulose

Dipotassium Glycyrrhizate

Disodium EDTA

Malachite Extract

Hydrolyzed Hyaluronic Acid

Hydroxyacetophenone

Madecassoside

Asiaticoside

Asiatic Acid

Madecassic Acid

Sodium Acetylated Hyaluronate

Water, Butylene Glycol, Sodium Hyaluronate, 1,2-Hexanediol, Panthenol, Glycerin, Glyceryl Glucoside, Caprylyl Glycol, Pentylene Glycol, Hydroxyethylcellulose, Allantoin, Dipotassium Glycyrrhizate, Disodium EDTA, Malachite Extract, Copper Tripeptide-1, Hydrolyzed Hyaluronic Acid, Hydroxyacetophenone, Ethylhexylglycerin, Madecassoside, Asiaticoside, Asiatic Acid, Madecassic Acid, Sodium Acetylated Hyaluronate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.

Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.

Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.

It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.

Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.

This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.

Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.

Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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