Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Curology The Rich Moisturizer Versus Paula's Choice Resist Skin Restoring Moisturizer With SPF 50

Curology The Rich Moisturizer Versus Paula's Choice Resist Skin Restoring Moisturizer With SPF 50 This barrier-repair moisturizer is formulated around Allantoin and Niacinamide to strengthen the skin barrier and soften the look of wrinkles. What's inside Key I

Curology The Rich Moisturizer Versus Paula's Choice Resist Skin Restoring Moisturizer With SPF 50

This barrier-repair moisturizer is formulated around Allantoin and Niacinamide to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Caprylic/Capric Triglyceride

Cetearyl Alcohol

Cetyl Alcohol

Aloe Barbadensis Leaf Juice

Squalane

Glycerin

Dimethicone

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Limnanthes Alba Seed Oil

Sodium Hyaluronate

Butyrospermum Parkii Butter

Cetearyl Olivate

Sorbitan Olivate

Argania Spinosa Kernel Oil

Sodium PCA

Allantoin

Isohexadecane

Cetearyl Glucoside

Polysorbate 60

Sorbitan Isostearate

Phenoxyethanol

Ethylhexylglycerin

Citric Acid

Sodium Hydroxide

Water, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Cetyl Alcohol, Aloe Barbadensis Leaf Juice, Squalane, Glycerin, Dimethicone, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Limnanthes Alba Seed Oil, Sodium Hyaluronate, Butyrospermum Parkii Butter, Cetearyl Olivate, Sorbitan Olivate, Argania Spinosa Kernel Oil, Sodium PCA, Allantoin, Isohexadecane, Cetearyl Glucoside, Polysorbate 60, Sorbitan Isostearate, Phenoxyethanol, Ethylhexylglycerin, Citric Acid, Sodium Hydroxide

Butyl Methoxydibenzoylmethane 3%

Homosalate 5%

Ethylhexyl Methoxycinnamate 7.5%

Ethylhexyl Salicylate 5%

Benzophenone-3

Silica

Butylene Glycol

Pentylene Glycol

Potassium Cetyl Phosphate

Cyclopentasiloxane

Pyrus Malus Fruit Extract

Vp/Eicosene Copolymer

Niacinamide

Tocopherol

Glycyrrhiza Glabra Root Extract

Atractylodes Macrocephala Root Powder

Avena Sativa Kernel Extract

Coffea Arabica Seed Extract

Portulaca Oleracea Extract

Mahonia Aquifolium Root Extract

Diethylhexyl Syringylidenemalonate

Sarcosine

Capryloyl Glycine

Maltooligosyl Glucoside

Dimethiconol

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Hydrogenated Starch Hydrolysate

Hexylene Glycol

4-T-Butylcyclohexanol

Glyceryl Stearate

PEG-100 Stearate

Xanthan Gum

Disodium EDTA

Caprylyl Glycol

Butyl Methoxydibenzoylmethane 3%, Homosalate 5%, Ethylhexyl Methoxycinnamate 7.5%, Ethylhexyl Salicylate 5%, Benzophenone-3, Water, Silica, Glycerin, Cetearyl Alcohol, Dimethicone, Butylene Glycol, Pentylene Glycol, Potassium Cetyl Phosphate, Cyclopentasiloxane, Pyrus Malus Fruit Extract, Vp/Eicosene Copolymer, Butyrospermum Parkii Butter, Allantoin, Niacinamide, Tocopherol, Glycyrrhiza Glabra Root Extract, Aloe Barbadensis Leaf Juice, Atractylodes Macrocephala Root Powder, Avena Sativa Kernel Extract, Coffea Arabica Seed Extract, Portulaca Oleracea Extract, Mahonia Aquifolium Root Extract, Diethylhexyl Syringylidenemalonate, Sarcosine, Capryloyl Glycine, Maltooligosyl Glucoside, Cetearyl Glucoside, Dimethiconol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Hydrogenated Starch Hydrolysate, Hexylene Glycol, 4-T-Butylcyclohexanol, Glyceryl Stearate, PEG-100 Stearate, Sodium Hydroxide, Xanthan Gum, Disodium EDTA, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.

Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.

Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.

It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.

Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.

This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.

Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.

Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.

Aloe Barbadensis Leaf Juice is the filtered, stabilized liquid pressed from the inner gel of the aloe vera leaf.

In cosmetics, it shows up as either soothing active or a water-replacement base. It is roughly 98-99% water and the last 1-2% is an interesting mix of polysaccharides, amino acids, vitamins, minerals, and enzymes.

The polysaccharides do most of the work: they bind water at the skin surface for a light, non-greasy hydration boost. And one of the polysaccharides, glycomannan, is linked to fibroblast stimulation + collagen synthesis. This is also why aloe has such a long track record in wound and burn healing.

This ingredient is also calming with anti-inflammatory and mild antimicrobial activity, making it a great pick for sensitive, irritated, or post-sun skin.

Realistic expectations matter though; the solid evidence is mostly limited to hydration, soothing, and wound support. Deeper claims about anti-aging or sun protection are not well backed, and science reviews note it does not prevent radiation-induced skin injury.

Because it plays well with almost everything, it's commonly used as a base alongside other actives like niacinamide or vitamin C.

Typical usage concentrations range from 0.5% (where hydration benefits already show up) all the way to 90%+ (where it replaces water as the main base).

The safety for this ingredient is well-establish as well. Overall, this is a great supporting ingredient for those who want a boost in hydration.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Cetearyl Glucoside is a sugar-based emulsifier. It is usually made by combining cetearyl alcohol and glucose.

Belonging to the aklyl polyglucoside (APG) family, Cetearyl Glucoside has a sugar "head" that loves water and a fatty "tail" that loves oil. This means it can shuffle oil and water into a stable and smooth emulsion.

Typical use levels are between 1-5% and this ingredient is considered to be non-irritating by the CIR Expert Panel Review.

Once applied, your skin's glucoside hydrolases breaks it down to the parent fatty alcohol and glucose. This is why this ingredient may not be fungal acne safe.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Water
  2. 02Lactic Acid
  3. 03Glycerin
  4. 04Pentylene Glycol
  5. 05Propanediol
  6. 06Sodium Hydroxide
  7. 07Sodium Hyaluronate Crosspolymer
  8. 08Tasmannia Lanceolata Fruit/Leaf Extract
  9. 09Acacia Senegal Gum
  10. 10Xanthan Gum
  11. 11Isoceteth-20
  12. 12Trisodium Ethylenediamine Disuccinate
  13. 13Ethylhexylglycerin
  14. 141,2-Hexanediol
  15. 15Caprylyl Glycol
  16. 16Water, Lactic Acid, Glycerin, Pentylene Glycol, Propanediol, Sodium Hydroxide, Sodium Hyaluronate Crosspolymer, Tasmannia Lanceolata Fruit/Leaf Extract, Acacia Senegal Gum, Xanthan Gum, Isoceteth-20, Trisodium Ethylenediamine Disuccinate, Ethylhexyl…
  17. 17Butylene Glycol
  18. 18Niacinamide
  19. 19Polysorbate 20
  20. 20Adenosine
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side