Depology Matriplex Peptide Intense Cream Versus Skinfix Barrier+ Triple Lipid-Peptide Cream

Depology Matriplex Peptide Intense Cream Versus Skinfix Barrier+ Triple Lipid-Peptide Cream

This anti-aging moisturizer is formulated around Centella Asiatica Extract and Niacinamide to soften the look of wrinkles and strengthen the skin barrier.

This barrier-repair moisturizer is formulated around Butyrospermum Parkii Butter and Ceramide NP to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Centella Asiatica Extract

Butylene Glycol

Glycerin

Water

Cyclohexasiloxane

Panthenol

Sorbitan Olivate

Cetearyl Olivate

Melaleuca Alternifolia Leaf Extract

Niacinamide

1,2-Hexanediol

Camellia Sinensis Leaf Extract

Stearyl Alcohol

Glyceryl Stearate

Melia Azadirachta Flower Extract

Melia Azadirachta Leaf Extract

Houttuynia Cordata Extract

Glycine Max Seed Extract

Sodium PCA

Sodium Polystyrene Sulfonate

Sodium Hyaluronate

Sorghum Bicolor Stalk Juice

Pentylene Glycol

Ethylhexylglycerin

Adenosine

Carbomer

Sodium Lactate

Hydroxypropyl Cyclodextrin

Polysorbate 20

Sodium Benzoate

Potassium Sorbate

Caprylyl Glycol

N-Prolyl Palmitoyl Tripeptide-56 Acetate

Palmitoyl Tripeptide-38

Madecassoside

Asiaticoside

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Asiatic Acid

Madecassic Acid

Centella Asiatica Extract, Butylene Glycol, Glycerin, Water, Cyclohexasiloxane, Panthenol, Sorbitan Olivate, Cetearyl Olivate, Melaleuca Alternifolia Leaf Extract, Niacinamide, 1,2-Hexanediol, Camellia Sinensis Leaf Extract, Stearyl Alcohol, Glyceryl Stearate, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Houttuynia Cordata Extract, Glycine Max Seed Extract, Sodium PCA, Sodium Polystyrene Sulfonate, Sodium Hyaluronate, Sorghum Bicolor Stalk Juice, Pentylene Glycol, Ethylhexylglycerin, Adenosine, Carbomer, Sodium Lactate, Hydroxypropyl Cyclodextrin, Polysorbate 20, Sodium Benzoate, Potassium Sorbate, Caprylyl Glycol, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Palmitoyl Tripeptide-38, Madecassoside, Asiaticoside, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Asiatic Acid, Madecassic Acid

Caprylic/Capric Triglyceride

Butyrospermum Parkii Butter

Olus Oil

Cetyl Lactate

Propanediol

C12-16 Alcohols

Caprylyl Caprylate/Caprate

Jojoba Oil/Macadamia Seed Oil Esters

Glyceryl Stearate Citrate

Palmitic Acid

Hydrogenated Lecithin

Oryza Sativa Bran Extract

Dilinoleic Acid/Propanediol Copolymer

Squalene

Ophiopogon Japonicus Root Extract

Xanthan Gum

Phytosteryl Sunflowerseedate

Glycine Soja Extract

Ceramide NP

Ceramide AP

Ceramide EOP

Hydrolyzed Rice Protein

Chondrus Crispus Extract

Hydrogenated Vegetable Glycerides

Helianthus Annuus Extract

Citric Acid

Phytosteryl Macadamiate

Tocopherol

Rosmarinus Officinalis Leaf Extract

Aloe Barbadensis Leaf Juice

Trisodium Ethylenediamine Disuccinate

Phytosterols

Sodium Lauroyl Lactylate

Gluconolactone

Phenethyl Alcohol

Phytosphingosine

Cholesterol

Phenoxyethanol

Water, Caprylic/Capric Triglyceride, Glycerin, Butyrospermum Parkii Butter, Olus Oil, Cetyl Lactate, Propanediol, C12-16 Alcohols, Caprylyl Caprylate/Caprate, Jojoba Oil/Macadamia Seed Oil Esters, Glyceryl Stearate Citrate, Palmitic Acid, Hydrogenated Lecithin, Oryza Sativa Bran Extract, Dilinoleic Acid/Propanediol Copolymer, Squalene, Ophiopogon Japonicus Root Extract, Xanthan Gum, Phytosteryl Sunflowerseedate, Glycine Soja Extract, Pentylene Glycol, Ceramide NP, Ceramide AP, Ceramide EOP, Hydrolyzed Rice Protein, Chondrus Crispus Extract, Hydrogenated Vegetable Glycerides, Helianthus Annuus Extract, Sodium Hyaluronate, Citric Acid, Phytosteryl Macadamiate, Tocopherol, Rosmarinus Officinalis Leaf Extract, Aloe Barbadensis Leaf Juice, Trisodium Ethylenediamine Disuccinate, Phytosterols, Sodium Lauroyl Lactylate, Gluconolactone, Phenethyl Alcohol, Phytosphingosine, Cholesterol, Carbomer, Potassium Sorbate, Ethylhexylglycerin, Sodium Benzoate, Phenoxyethanol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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