Dermalogica Pro-Collagen Banking Serum Versus Peter Thomas Roth Peptide 21 Wrinkle Resist Serum

Dermalogica Pro-Collagen Banking Serum Versus Peter Thomas Roth Peptide 21 Wrinkle Resist Serum

This anti-aging serum is formulated around Trehalose and Carnosine to soften the look of wrinkles and strengthen the skin barrier.

This anti-aging serum is formulated around Tripeptide-10 Citrulline and Acetyl Octapeptide-3 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Pentylene Glycol

Coco-Caprylate/Caprate

Glycerin

Propanediol

Simmondsia Chinensis Seed Oil

Trehalose

Oryza Sativa Bran Water

Butylene Glycol

Ethoxydiglycol

Triheptanoin

Arginine PCA

Diglycerin

Dipotassium Glycyrrhizate

Sodium Hyaluronate

Collagen Amino Acids

Glycine Soja Oil

Helianthus Annuus Seed Oil

Citrus Aurantium Dulcis Peel Oil

Citrus Aurantium Bergamia Fruit Oil

Citrus Paradisi Peel Oil

Rosmarinus Officinalis Leaf Extract

Cupressus Sempervirens Leaf/Nut/Stem Oil

Santalum Album Oil

Citrus Limon Peel Oil

Rosa Damascena Flower Oil

Jasminum Sambac Flower Extract

Hydrolyzed Jojoba Esters

Oryza Sativa Bran Extract

Aloe Barbadensis Leaf Extract

Tephrosia Purpurea Seed Extract

Helianthus Annuus Extract

Juniperus Virginiana Oil

Tagetes Minuta Flower Oil

Rosmarinus Officinalis Leaf Oil

Cistus Ladaniferus Leaf/Stem Extract

Hydrolyzed Rice Protein

Tocopheryl Acetate

Tocopherol

Phospholipids

Carnosine

Glyceryl Stearate Citrate

Caprylyl Glycol

Polyglutamic Acid

Glycolipids

Glycine Soja Sterols

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Glyceryl Caprylate

Sclerotium Gum

Polyquaternium-80

Didecyldimonium Chloride

Dianthus Caryophyllus Flower Extract

Xanthan Gum

Methylpropanediol

Cetearyl Alcohol

PEG-40 Hydrogenated Castor Oil

Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer

Phytic Acid

Polysorbate 20

Tetrasodium Glutamate Diacetate

Citric Acid

Sodium Hydroxide

Sodium Polyacryloyldimethyl Taurate

Sodium Benzoate

Potassium Sorbate

Limonene

Linalool

Water, Pentylene Glycol, Coco-Caprylate/Caprate, Glycerin, Propanediol, Simmondsia Chinensis Seed Oil, Trehalose, Oryza Sativa Bran Water, Butylene Glycol, Ethoxydiglycol, Triheptanoin, Arginine PCA, Diglycerin, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Collagen Amino Acids, Glycine Soja Oil, Helianthus Annuus Seed Oil, Citrus Aurantium Dulcis Peel Oil, Citrus Aurantium Bergamia Fruit Oil, Citrus Paradisi Peel Oil, Rosmarinus Officinalis Leaf Extract, Cupressus Sempervirens Leaf/Nut/Stem Oil, Santalum Album Oil, Citrus Limon Peel Oil, Rosa Damascena Flower Oil, Jasminum Sambac Flower Extract, Hydrolyzed Jojoba Esters, Oryza Sativa Bran Extract, Aloe Barbadensis Leaf Extract, Tephrosia Purpurea Seed Extract, Helianthus Annuus Extract, Juniperus Virginiana Oil, Tagetes Minuta Flower Oil, Rosmarinus Officinalis Leaf Oil, Cistus Ladaniferus Leaf/Stem Extract, Hydrolyzed Rice Protein, Tocopheryl Acetate, Tocopherol, Phospholipids, Carnosine, Glyceryl Stearate Citrate, Caprylyl Glycol, Polyglutamic Acid, Glycolipids, Glycine Soja Sterols, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glyceryl Caprylate, Sclerotium Gum, Polyquaternium-80, Didecyldimonium Chloride, Dianthus Caryophyllus Flower Extract, Xanthan Gum, Methylpropanediol, Cetearyl Alcohol, PEG-40 Hydrogenated Castor Oil, Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer, Phytic Acid, Polysorbate 20, Tetrasodium Glutamate Diacetate, Citric Acid, Sodium Hydroxide, Sodium Polyacryloyldimethyl Taurate, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool

Rosa Centifolia Flower Water

Isopropyl Myristate

Squalane

Mannitol

Natto Gum

Tripeptide-10 Citrulline

Acetyl Octapeptide-3

Palmitoyl Hexapeptide-12

Acetyl Tetrapeptide-11

Acetyl Hexapeptide-8

Acetyl Hexapeptide-1

Palmitoyl Oligopeptide

Acetyl Tetrapeptide-9

Acetyl Tetrapeptide-2

Tripeptide-1

Palmitoyl Tetrapeptide-7

Hexapeptide-11

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Palmitoyl Tripeptide-5

Trifluoroacetyl Tripeptide-2

Palmitoyl Tripeptide-1

Sodium Polyglutamate

Retinyl Palmitate

Ascorbic Acid

Hydrolyzed Soy Protein

Hydrolyzed Wheat Protein

Lecithin

Pseudoalteromonas Ferment Extract

Acrylates Copolymer

Magnesium Chloride

Dimethyl Isosorbide

Leuconostoc/Radish Root Ferment Filtrate

PEG-8 Dimethicone

Disodium Phosphate

Carbomer

Dextran

Sodium Lactate

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Triethanolamine

Sodium Phosphate

Octyldodecanol

Silica

Sodium Propoxyhydroxypropyl Thiosulfate Silica

Phenoxyethanol

Water, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Ferment Extract, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc/Radish Root Ferment Filtrate, PEG-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.

It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.

The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.

Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).

True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.

Because it is derived from lauric acid, it may not be fungal acne safe.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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