Skin science article
Dieux Skin Air Angel Peptide Plumping Gel Cream Versus Prequel AM/PM Modern Moisturizer
Dieux Skin Air Angel Peptide Plumping Gel Cream Versus Prequel AM/PM Modern Moisturizer This barrier-repair moisturizer is formulated around Palmitoyl Hexapeptide-12 and Squalane to strengthen the skin barrier and hydrate skin. This barrier-repair moisturizer
Dieux Skin Air Angel Peptide Plumping Gel Cream Versus Prequel AM/PM Modern Moisturizer
This barrier-repair moisturizer is formulated around Palmitoyl Hexapeptide-12 and Squalane to strengthen the skin barrier and hydrate skin.
This barrier-repair moisturizer is formulated around Simmondsia Chinensis Seed Oil and Squalane to strengthen the skin barrier and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Dimethicone
Dimethicone Crosspolymer
C12-15 Alkyl Benzoate
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Imperata Cylindrica Root Extract
Caprylic/Capric Triglyceride
Methylpropanediol
Squalane
Cetyl Alcohol
Meadowfoam Estolide
Dipalmitoyl Hydroxyproline
Tribehenin
Sodium PCA
Urea
Carbomer
Phenoxyethanol
Caprylyl Glycol
Collagen Amino Acids
Propanediol
Haematococcus Pluvialis Extract
Trehalose
Linoleic Acid
Phytosterols
Phospholipids
Palmitic Acid
Polysorbate 60
Sorbitan Isostearate
Ceramide Ng
Hexylene Glycol
PEG-10 Phytosterol
Polyquaternium-51
Triacetin
Sodium Hyaluronate
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Palmitoyl Hexapeptide-12
Sodium Hydroxide
Lactic Acid
Water, Glycerin, Dimethicone, Dimethicone Crosspolymer, C12-15 Alkyl Benzoate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Imperata Cylindrica Root Extract, Caprylic/Capric Triglyceride, Methylpropanediol, Squalane, Cetyl Alcohol, Meadowfoam Estolide, Dipalmitoyl Hydroxyproline, Tribehenin, Sodium PCA, Urea, Carbomer, Phenoxyethanol, Caprylyl Glycol, Collagen Amino Acids, Propanediol, Haematococcus Pluvialis Extract, Trehalose, Linoleic Acid, Phytosterols, Phospholipids, Palmitic Acid, Polysorbate 60, Sorbitan Isostearate, Ceramide Ng, Hexylene Glycol, PEG-10 Phytosterol, Polyquaternium-51, Triacetin, Sodium Hyaluronate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Palmitoyl Hexapeptide-12, Sodium Hydroxide, Lactic Acid
Simmondsia Chinensis Seed Oil
Glyceryl Stearate
Stearyl Alcohol
Oleic/Linoleic/Linolenic Polyglycerides
Ceramide NP
Polyglyceryl-6 Laurate
Polyglyceryl-6 Oleate
Saccharide Isomerate
Lecithin
Sorbitan Oleate
Hydrogenated Lecithin
Acetyl Heptapeptide-4
Stearic Acid
Hydroxyacetophenone
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer
Ceramide As
Ceramide Ns
Ceramide EOP
Ceramide AP
Linolenic Acid
Bacillus/Sea Salt Ferment Filtrate
Isohexadecane
Boron Nitride
1,2-Hexanediol
Chlorphenesin
Tocopheryl Acetate
Dicaprylyl Ether
Polysorbate 80
Aluminum Starch Octenylsuccinate
Citric Acid
Myristic Acid
Tocopherol
Sodium Citrate
Water, Glycerin, Dimethicone, Simmondsia Chinensis Seed Oil, Squalane, Glyceryl Stearate, Cetyl Alcohol, Stearyl Alcohol, Oleic/Linoleic/Linolenic Polyglycerides, Ceramide NP, Polyglyceryl-6 Laurate, Polyglyceryl-6 Oleate, Saccharide Isomerate, Lecithin, Sorbitan Oleate, Hydrogenated Lecithin, Linoleic Acid, Sodium Hyaluronate, Acetyl Heptapeptide-4, Stearic Acid, Hydroxyacetophenone, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Ceramide As, Ceramide Ns, Ceramide EOP, Ceramide AP, Linolenic Acid, Palmitic Acid, Bacillus/Sea Salt Ferment Filtrate, Isohexadecane, Boron Nitride, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dicaprylyl Ether, Polysorbate 80, Aluminum Starch Octenylsuccinate, Sodium Hydroxide, Citric Acid, Phenoxyethanol, Myristic Acid, Tocopherol, Sodium Citrate
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.
As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.
It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.
A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Linoleic Acid is also known as Vitamin F. It is a fatty acid with emollient and skin conditioning properties.
Our top layer of skin, or epidermis, naturally contains high amounts of linoleic acid.
Your body uses linoleic acid to build ceramides and prostaglandins. Ceramides keep your skin's barrier hydrated and strong while prosaglandins help control inflammation and healing.
Needless to say, linoleic acid is crucial for having a strong skin barrier.
One study found applying linoleic acid rich sunflower oil to be more effective at repairing the skin barrier than olive oil.
This ingredient can also help treat acne by softening sebum to prevent clogged pores. Another study found using 2.5% linoleic acid gel for 4 weeks showed a 25% reduction in small comedones.
Studies show it can also help lighten hyperpigmentation or sun spots by disrupting the melanin production process. It also helps your skin shed melanin pigment from your skin caused by UV exposure.
Due to its role in the production of the fatty acid prostaglandin, linoleic acid can also help reduce inflammation and support wound healing.
Fun fact: Linoleic acid is an essential fatty acid. This means our bodies cannot create it on its own and we need to get it through foods such as nuts and vegetable oils.
Just know this ingredient is not always fungal-acne safe because it is a long-chain fatty acid (with 18 carbon atoms) that directly feeds the Malassezia yeast responsible for fungal acne.
Palmitic Acid is a fatty acid naturally found in our skin and in many plant and animal sources.
In cosmetics, it is usually derived from palm oil. It serves many purposes in skincare, acting as a cleanser, emollient, and emulsifier.
Interestingly, topically applied Palmitic Acid can be elongated into longer chain fatty acids and ceramides. A 2019 study found low levels of Palmitic Acid lead to slower development of cells, suggesting it plays a role in keeping your skin's renewal process on track.
The CIR (Cosmetic Ingredient Review) panel determined it safe as used in cosmetics at concentrations up to 13%. It is non-irritating and non-sensitizing in clinical studies.
The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Palmitic Acid, at C16, falls right into that sweet spot.
In vitro studies have shown that Palmitic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.
It's worth noting that what feeds yeast in a lab doesn't necessarily feed it on your face since formulation and your skin's chemistry play a bigger role.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!