Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Dieux Skin Air Angel Peptide Plumping Gel Cream Versus Tatcha The Dewy Skin Cream

Dieux Skin Air Angel Peptide Plumping Gel Cream Versus Tatcha The Dewy Skin Cream This barrier-repair moisturizer is formulated around Palmitoyl Hexapeptide-12 and Squalane to strengthen the skin barrier and hydrate skin. This barrier-repair moisturizer is for

Dieux Skin Air Angel Peptide Plumping Gel Cream Versus Tatcha The Dewy Skin Cream

This barrier-repair moisturizer is formulated around Palmitoyl Hexapeptide-12 and Squalane to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Saccharomyces/Rice Ferment Filtrate and Squalane to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dimethicone

Dimethicone Crosspolymer

C12-15 Alkyl Benzoate

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Imperata Cylindrica Root Extract

Caprylic/Capric Triglyceride

Methylpropanediol

Squalane

Cetyl Alcohol

Meadowfoam Estolide

Dipalmitoyl Hydroxyproline

Tribehenin

Sodium PCA

Urea

Carbomer

Phenoxyethanol

Caprylyl Glycol

Collagen Amino Acids

Propanediol

Haematococcus Pluvialis Extract

Trehalose

Linoleic Acid

Phytosterols

Phospholipids

Palmitic Acid

Polysorbate 60

Sorbitan Isostearate

Ceramide Ng

Hexylene Glycol

PEG-10 Phytosterol

Polyquaternium-51

Triacetin

Sodium Hyaluronate

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Palmitoyl Hexapeptide-12

Sodium Hydroxide

Lactic Acid

Water, Glycerin, Dimethicone, Dimethicone Crosspolymer, C12-15 Alkyl Benzoate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Imperata Cylindrica Root Extract, Caprylic/Capric Triglyceride, Methylpropanediol, Squalane, Cetyl Alcohol, Meadowfoam Estolide, Dipalmitoyl Hydroxyproline, Tribehenin, Sodium PCA, Urea, Carbomer, Phenoxyethanol, Caprylyl Glycol, Collagen Amino Acids, Propanediol, Haematococcus Pluvialis Extract, Trehalose, Linoleic Acid, Phytosterols, Phospholipids, Palmitic Acid, Polysorbate 60, Sorbitan Isostearate, Ceramide Ng, Hexylene Glycol, PEG-10 Phytosterol, Polyquaternium-51, Triacetin, Sodium Hyaluronate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Palmitoyl Hexapeptide-12, Sodium Hydroxide, Lactic Acid

Saccharomyces/Rice Ferment Filtrate

Diisostearyl Malate

Behenyl Alcohol

Myristyl Myristate

Dipentaerythrityl Hexahydroxystearate

Bis-Diglyceryl Polyacyladipate-2

Tridecyl Trimellitate

Inositol

Sorbitan Tristearate

Beheneth-20

Camellia Sinensis Leaf Extract

Cladosiphon Okamuranus Extract

Chondrus Crispus Extract

Betaphycus Gelatinum Extract

Oryza Sativa Bran Extract

Panax Ginseng Root Extract

Origanum Majorana Leaf Extract

Thymus Serpyllum Extract

Malva Sylvestris Flower Extract

Gold

Sericin

Phytosteryl Macadamiate

Tocopherol

Butylene Glycol

Dimethicone/Vinyl Dimethicone Crosspolymer

Sodium Benzoate

Gluconolactone

Ethylhexylglycerin

Parfum

Alcohol

Citral

Limonene

Linalool

Mica

Tin Oxide

CI 77891

CI 60725

Water, Saccharomyces/Rice Ferment Filtrate, Glycerin, Propanediol, Dimethicone, Squalane, Diisostearyl Malate, Behenyl Alcohol, Myristyl Myristate, Dipentaerythrityl Hexahydroxystearate, Bis-Diglyceryl Polyacyladipate-2, Tridecyl Trimellitate, Inositol, Sorbitan Tristearate, Beheneth-20, Camellia Sinensis Leaf Extract, Cladosiphon Okamuranus Extract, Chondrus Crispus Extract, Betaphycus Gelatinum Extract, Oryza Sativa Bran Extract, Panax Ginseng Root Extract, Origanum Majorana Leaf Extract, Thymus Serpyllum Extract, Malva Sylvestris Flower Extract, Sodium Hyaluronate, Gold, Sericin, Phytosteryl Macadamiate, Tocopherol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Isostearate, Polysorbate 60, Butylene Glycol, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Benzoate, Gluconolactone, Ethylhexylglycerin, Parfum, Alcohol, Phenoxyethanol, Citral, Limonene, Linalool, Mica, Tin Oxide, CI 77891, CI 60725

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.

Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.

In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.

As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.

In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.

Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.
  4. 04As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.
  5. 05It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.
  6. 06A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.
  7. 07Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  8. 08Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  9. 09Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  10. 10Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
  11. 11Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
  12. 12It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
  13. 13Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
  14. 14A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
  15. 15Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
  16. 16Its main roles are:
  17. 17Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
  18. 18The FDA allows products labeled "alcohol-free" to have fatty alcohols.
  19. 19This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
  20. 20Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side