Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Dr. Barbara Sturm Super Anti-Aging Face Cream Versus PCA Skin ReBalance

Dr. Barbara Sturm Super Anti-Aging Face Cream Versus PCA Skin ReBalance This anti-aging moisturizer is formulated around Ceramide NP to soften the look of wrinkles and hydrate skin. This calming moisturizer is formulated around Niacinamide and Bisabolol to cal

Dr. Barbara Sturm Super Anti-Aging Face Cream Versus PCA Skin ReBalance

This anti-aging moisturizer is formulated around Ceramide NP to soften the look of wrinkles and hydrate skin.

This calming moisturizer is formulated around Niacinamide and Bisabolol to calm redness and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Caprylic/Capric Triglyceride

Decyl Oleate

Butyrospermum Parkii Butter

Glycerin

Hydrogenated Lecithin

Pentylene Glycol

Lactobacillus/Portulaca Oleracea Ferment Extract

Olea Europaea Fruit Oil

Persea Gratissima Oil

Tocopheryl Acetate

Ceramide NP

Sodium Hyaluronate

Polygonum Bistorta Root Extract

Leuconostoc/Radish Root Ferment Filtrate

Plankton Extract

Phenoxyethanol

Panthenol

C12-16 Alcohols

Palmitic Acid

Squalane

Xanthan Gum

Carbomer

Ethylhexylglycerin

Helianthus Annuus Seed Oil

Tocopherol

Teprenone

Sodium Hydroxide

Hexylene Glycol

Pantolactone

Caprylyl Glycol

Citric Acid

Water, Caprylic/Capric Triglyceride, Decyl Oleate, Butyrospermum Parkii Butter, Glycerin, Hydrogenated Lecithin, Pentylene Glycol, Lactobacillus/Portulaca Oleracea Ferment Extract, Olea Europaea Fruit Oil, Persea Gratissima Oil, Tocopheryl Acetate, Ceramide NP, Sodium Hyaluronate, Polygonum Bistorta Root Extract, Leuconostoc/Radish Root Ferment Filtrate, Plankton Extract, Phenoxyethanol, Panthenol, C12-16 Alcohols, Palmitic Acid, Squalane, Xanthan Gum, Carbomer, Ethylhexylglycerin, Helianthus Annuus Seed Oil, Tocopherol, Teprenone, Sodium Hydroxide, Hexylene Glycol, Pantolactone, Caprylyl Glycol, Citric Acid

Ethylhexyl Isononanoate

Glycereth-26

Butylene Glycol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Niacinamide

Polyisobutene

Bisabolol

PEG-7 Trimethylolpropane Coconut Ether

Oenothera Biennis Oil

Borago Officinalis Seed Oil

Aloe Barbadensis Leaf Juice

Water, Ethylhexyl Isononanoate, Glycereth-26, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Phenoxyethanol, Niacinamide, Carbomer, Polyisobutene, Caprylyl Glycol, Bisabolol, Sodium Hydroxide, Ethylhexylglycerin, Hexylene Glycol, PEG-7 Trimethylolpropane Coconut Ether, Tocopheryl Acetate, Oenothera Biennis Oil, Borago Officinalis Seed Oil, Aloe Barbadensis Leaf Juice, Sodium Hyaluronate

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Hexylene Glycol is a multitasker ingredient that works as a solvent, humectant, emulsifier, viscosity reducer, and preservative booster.

It is able to dissolve both water and oil-soluble ingredients to stabilize tricky actives and make products spread more easily.

As a humectant, it pulls water into the skin. But it's a pretty minor moisturizing ingredient compared to other humectants, like glycerin.

Interestingly, it can act as a mild penetration enhancer. One in vitro study on human skin found a 12% concentration upped the absorption of mometasone furoate (a medicinal ingredient used to treat inflammatory skin conditions) up to 7%.

This ingredient is typically used at levels of 0.1-10% depending on the role it's playing.

A patch test study on eczema patients didn't find a significant increase in irritation versus the control group, but the potential for irritation rises at higher concentrations.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Azelaic acid is a multitasker ingredient that helps treat acne, pigmentation, and irritation. It is a great option for sensitive skin.
  4. 04What makes it special?
  5. 05OTC Azelaic acid is usually available in concentrations from 10-15% and anything over requires a prescription.
  6. 06Here's what each tier does best:
  7. 07Unlike other acids, azelaic acid will not make your skin more photosensitive/sun sensitive.
  8. 08Though this ingredient is naturally occurring in grains like wheat, rye, and barley, it is usually synthetically created for cosmetics to ensure stability and effectiveness.
  9. 09Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
  10. 10So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
  11. 11You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Source · skinsort.com
02

Product index

Related product references

Product

PCA Skin Dry Skin Relief Bar®

PCA Skin Dry Skin Relief Bar® PCA Skin Dry Skin Relief Bar® ingredients explained: Salicylic Acid (3%), Glycerin, Cocos Nucifera (Coconut) Oil, Elaeis Guineensis (Palm) Kernel Oil, Ricinus …

Source: incidecoder.comView reference →

Product

PCA Skin Body Therapy

PCA Skin Body Therapy PCA Skin Body Therapy ingredients explained: Water, Lactic Acid, Glycerin, Jojoba Esters, Ammonium Lactate, Polyglyceryl-10 Dioleate, Caprylic/Capric Triglyceride, Cyc…

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side