DRMTLGY Needle-Less Serum Versus Niod Copper Amino Isolate Serum 2:1 (CAIS2)

DRMTLGY Needle-Less Serum Versus Niod Copper Amino Isolate Serum 2:1 (CAIS2)

This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles.

This serum is formulated around Lactococcus Ferment Lysate to support the skin barrier and reduce redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Sodium Chondroitin Sulfate

Sodium Hyaluronate

Pisum Sativum Extract

Bambusa Vulgaris Leaf/Stem Extract

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Ceramide EOP

Glucosamine Hcl

Glycosaminoglycans

Ceramide NP

Palmitoyl Tripeptide-5

Ceramide AP

Phytosphingosine

Cholesterol

Niacinamide

Sodium Lauroyl Lactylate

Methylglucoside Phosphate

Copper Lysinate/Prolinate

Panthenol

Tocopheryl Acetate

Phenoxyethanol

Polysorbate 20

Ethylhexylglycerin

Disodium EDTA

Butylene Glycol

Carbomer

Xanthan Gum

Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum Extract, Bambusa Vulgaris Leaf/Stem Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Glucosamine Hcl, Glycosaminoglycans, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Panthenol, Tocopheryl Acetate, Phenoxyethanol, Polysorbate 20, Ethylhexylglycerin, Disodium EDTA, Butylene Glycol, Carbomer, Xanthan Gum

Lactococcus Ferment Lysate

Ethyl Linoleate

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Hexanoyl Dipeptide-3 Norleucine Acetate

Myristoyl Nonapeptide-3

Yeast Extract

Soy Amino Acids

Bisabolol

Pseudoalteromonas Exopolysaccharides

Lecithin

Sorbitan Isostearate

Isohexadecane

Polysorbate 60

Polyacrylate Crosspolymer-6

Trisodium Ethylenediamine Disuccinate

Sodium Salicylate

Citric Acid

Sodium Chloride

Potassium Sorbate

Sodium Benzoate

Pentylene Glycol

Ethoxydiglycol

Chlorphenesin

Water, Lactococcus Ferment Lysate, Glycerin, Ethyl Linoleate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hexanoyl Dipeptide-3 Norleucine Acetate, Myristoyl Nonapeptide-3, Yeast Extract, Soy Amino Acids, Bisabolol, Pseudoalteromonas Exopolysaccharides, Lecithin, Sorbitan Isostearate, Isohexadecane, Polysorbate 60, Polyacrylate Crosspolymer-6, Trisodium Ethylenediamine Disuccinate, Sodium Salicylate, Citric Acid, Sodium Chloride, Potassium Sorbate, Sodium Benzoate, Pentylene Glycol, Ethoxydiglycol, Phenoxyethanol, Chlorphenesin

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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