Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

DRMTLGY Vitamin C E + F Versus PCA Skin ReBalance

DRMTLGY Vitamin C E + F Versus PCA Skin ReBalance This anti-aging serum is formulated around Ascorbic Acid and Tocopherol to soften the look of wrinkles and brighten dull-looking skin. This calming moisturizer is formulated around Niacinamide and Bisabolol to

DRMTLGY Vitamin C E + F Versus PCA Skin ReBalance

This anti-aging serum is formulated around Ascorbic Acid and Tocopherol to soften the look of wrinkles and brighten dull-looking skin.

This calming moisturizer is formulated around Niacinamide and Bisabolol to calm redness and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Ascorbic Acid

Ethoxydiglycol

PEG-40 Hydrogenated Castor Oil

PPG-26-Buteth-26

Glycerin

Tocopherol

Ferulic Acid

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Ceramide EOP

Ceramide NP

Palmitoyl Tripeptide-5

Ceramide AP

Phytosphingosine

Cholesterol

Sodium Lauroyl Lactylate

Butylene Glycol

Carbomer

Polysorbate 20

Xanthan Gum

Sodium Hyaluronate

Sodium Metabisulfite

Acetyl Octapeptide-3

Phenoxyethanol

Triethanolamine

Panthenol

Water, Ascorbic Acid, Ethoxydiglycol, PEG-40 Hydrogenated Castor Oil, PPG-26-Buteth-26, Glycerin, Tocopherol, Ferulic Acid, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Phytosphingosine, Cholesterol, Sodium Lauroyl Lactylate, Butylene Glycol, Carbomer, Polysorbate 20, Xanthan Gum, Sodium Hyaluronate, Sodium Metabisulfite, Acetyl Octapeptide-3, Phenoxyethanol, Triethanolamine, Panthenol

Ethylhexyl Isononanoate

Glycereth-26

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Niacinamide

Polyisobutene

Caprylyl Glycol

Bisabolol

Sodium Hydroxide

Ethylhexylglycerin

Hexylene Glycol

PEG-7 Trimethylolpropane Coconut Ether

Tocopheryl Acetate

Oenothera Biennis Oil

Borago Officinalis Seed Oil

Aloe Barbadensis Leaf Juice

Water, Ethylhexyl Isononanoate, Glycereth-26, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Phenoxyethanol, Niacinamide, Carbomer, Polyisobutene, Caprylyl Glycol, Bisabolol, Sodium Hydroxide, Ethylhexylglycerin, Hexylene Glycol, PEG-7 Trimethylolpropane Coconut Ether, Tocopheryl Acetate, Oenothera Biennis Oil, Borago Officinalis Seed Oil, Aloe Barbadensis Leaf Juice, Sodium Hyaluronate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Water
  2. 02Lactic Acid
  3. 03Citric Acid
  4. 04Glycerin
  5. 05Aloe Barbadensis Leaf Juice
  6. 06Hydrastis Canadensis Extract
  7. 07Cucumis Sativus Fruit Extract
  8. 08Salvia Officinalis Leaf Extract
  9. 09Calendula Officinalis Flower Extract
  10. 10Arctium Lappa Root Extract
  11. 11Paullinia Cupana Seed Extract
  12. 12Hedera Helix Leaf/Stem Extract
  13. 13Tetrasodium EDTA
  14. 14Water, Lactic Acid, Citric Acid, Glycerin, Aloe Barbadensis Leaf Juice, Hydrastis Canadensis Extract, Cucumis Sativus Fruit Extract, Salvia Officinalis Leaf Extract, Calendula Officinalis Flower Extract, Arctium Lappa Root Extract, Paullinia Cupana …
  15. 15Cyclopentasiloxane
  16. 16Glycereth-26
  17. 17Polysorbate 20
  18. 18Dimethiconol
  19. 19Linoleic Acid
  20. 20Oleic Acid
Source · skinsort.com
02

Product index

Related product references

Product

PCA Skin Hydraluxe

PCA Skin Hydraluxe PCA Skin Hydraluxe ingredients explained: Water/Aqua/Eau, Niacinamide, Caprylic/Capric Triglyceride, Cetearyl Isononanoate, Dimethicone, Glycerin, Pentylene Glycol, Hydro…

Source: incidecoder.comView reference →

Product

PCA Skin Dual Action Redness Relief

PCA Skin Dual Action Redness Relief PCA Skin Dual Action Redness Relief ingredients explained: Water, Isododecane, Cyclopentasiloxane, Niacinamide, Dimethicone, Glycerin, Polyglyceryl-10 Di…

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side