Peptide Skincare & BeautySkin science and ingredient guides

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Drunk Elephant C-Tango Multivitamin Eye Cream Versus The Ordinary Multi-Peptide Eye Serum

Drunk Elephant C-Tango Multivitamin Eye Cream Versus The Ordinary Multi-Peptide Eye Serum This anti-aging eye moisturizer is formulated around Sodium Ascorbyl Phosphate and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and brighten dull-looking skin

Drunk Elephant C-Tango Multivitamin Eye Cream Versus The Ordinary Multi-Peptide Eye Serum

This anti-aging eye moisturizer is formulated around Sodium Ascorbyl Phosphate and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and brighten dull-looking skin.

This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Tripeptide-38 to soften the look of wrinkles and fade the look of dark spots.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dicaprylyl Carbonate

Cetearyl Alcohol

Caprylic/Capric Triglyceride

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Sodium Ascorbyl Phosphate

Cetearyl Olivate

Sorbitan Olivate

Sclerocarya Birrea Seed Oil

Persea Gratissima Oil

Plukenetia Volubilis Seed Oil

Magnesium Ascorbyl Phosphate

Ceteareth-6 Olivate

Tetrahexyldecyl Ascorbate

Ascorbyl Glucoside

Ascorbyl Palmitate

Palmitoyl Tripeptide-1

Glycine Soja Sterols

Linoleic Acid

Phospholipids

Ceramide NP

Glycine Soja Protein

Ceramide AP

Phytosphingosine

Cholesterol

Ceramide EOP

Cucumis Sativus Fruit Extract

Camellia Sinensis Leaf Extract

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Sodium Hyaluronate Crosspolymer

C12-15 Alkyl Benzoate

Panthenol

Dipotassium Glycyrrhizate

Hesperidin Methyl Chalcone

Dipeptide-2

Palmitoyl Tetrapeptide-7

Fragaria Ananassa Seed Extract

Medicago Sativa Extract

Morus Alba Leaf Extract

Hydrolyzed Rice Protein

Spilanthes Acmella Flower Extract

Aloe Barbadensis Leaf Juice

Ubiquinone

Superoxide Dismutase

Palmitoyl Tripeptide-38

Acetyl Hexapeptide-8

Pyrus Malus Fruit Extract

Phytic Acid

Actinidia Chinensis Fruit Extract

Vaccinium Myrtillus Leaf Extract

Tocopherol

Thioctic Acid

N-Hydroxysuccinimide

Chrysin

Mica

Ethylhexyl Palmitate

Phenoxyethanol

Pentylene Glycol

Sodium Lauroyl Lactylate

Titanium Dioxide

Hydroxypropyl Cyclodextrin

Sodium Benzoate

Xanthan Gum

Carbomer

Tocopheryl Acetate

Sodium Dextran Sulfate

Sorbitan Isostearate

Caprylyl Glycol

Steareth-20

Chlorhexidine Digluconate

Citric Acid

Chlorphenesin

Polysorbate 60

Potassium Sorbate

Ethylhexylglycerin

Water, Glycerin, Dicaprylyl Carbonate, Cetearyl Alcohol, Caprylic/Capric Triglyceride, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Ascorbyl Phosphate, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Persea Gratissima Oil, Plukenetia Volubilis Seed Oil, Magnesium Ascorbyl Phosphate, Ceteareth-6 Olivate, Tetrahexyldecyl Ascorbate, Ascorbyl Glucoside, Ascorbyl Palmitate, Palmitoyl Tripeptide-1, Glycine Soja Sterols, Linoleic Acid, Phospholipids, Ceramide NP, Glycine Soja Protein, Ceramide AP, Phytosphingosine, Cholesterol, Ceramide EOP, Cucumis Sativus Fruit Extract, Camellia Sinensis Leaf Extract, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Sodium Hyaluronate Crosspolymer, C12-15 Alkyl Benzoate, Panthenol, Dipotassium Glycyrrhizate, Hesperidin Methyl Chalcone, Dipeptide-2, Palmitoyl Tetrapeptide-7, Fragaria Ananassa Seed Extract, Medicago Sativa Extract, Morus Alba Leaf Extract, Hydrolyzed Rice Protein, Spilanthes Acmella Flower Extract, Aloe Barbadensis Leaf Juice, Ubiquinone, Superoxide Dismutase, Palmitoyl Tripeptide-38, Acetyl Hexapeptide-8, Pyrus Malus Fruit Extract, Phytic Acid, Actinidia Chinensis Fruit Extract, Vaccinium Myrtillus Leaf Extract, Tocopherol, Thioctic Acid, N-Hydroxysuccinimide, Chrysin, Mica, Ethylhexyl Palmitate, Phenoxyethanol, Pentylene Glycol, Sodium Lauroyl Lactylate, Titanium Dioxide, Hydroxypropyl Cyclodextrin, Sodium Benzoate, Xanthan Gum, Carbomer, Tocopheryl Acetate, Sodium Dextran Sulfate, Sorbitan Isostearate, Caprylyl Glycol, Steareth-20, Chlorhexidine Digluconate, Citric Acid, Chlorphenesin, Polysorbate 60, Potassium Sorbate, Ethylhexylglycerin

Butylene Glycol

Propanediol

Dipropylene Glycol

Acetyl Glucosamine

Niacinamide

Acetyl Tetrapeptide-5

Myristoyl Nonapeptide-3

Caffeine

Epigallocatechin Gallatyl Glucoside

Gallyl Glucoside

Fraxinus Excelsior Bark Extract

Silanetriol

Arginine

Hydroxymethoxyphenyl Decanone

Propyl Gallate

Maltodextrin

Hydroxyethylcellulose

Glycolic Acid

Sodium Citrate

Polysorbate 20

Trisodium Ethylenediamine Disuccinate

Dehydroacetic Acid

Benzyl Alcohol

Water, Glycerin, Butylene Glycol, Propanediol, Dipropylene Glycol, Acetyl Glucosamine, Niacinamide, Palmitoyl Tripeptide-38, Acetyl Tetrapeptide-5, Myristoyl Nonapeptide-3, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Caffeine, Epigallocatechin Gallatyl Glucoside, Gallyl Glucoside, Fraxinus Excelsior Bark Extract, Silanetriol, Arginine, Pentylene Glycol, Hydroxymethoxyphenyl Decanone, Propyl Gallate, Maltodextrin, Hydroxypropyl Cyclodextrin, Hydroxyethylcellulose, Xanthan Gum, Citric Acid, Glycolic Acid, Sodium Citrate, Polysorbate 20, Trisodium Ethylenediamine Disuccinate, Dehydroacetic Acid, Ethylhexylglycerin, Benzyl Alcohol, Phenoxyethanol, Chlorphenesin

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.

Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.

Chlorphenesin is soluble in both water and glycerin.

Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

This small molecule peptide has similar benefits to Argireline, the "botox" peptide.

According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.

While this seems promising, research is lacking in proving this ingredient to be as effective as botox.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

This ingredient is used in skincare as a delivery system.

It works by "encapsulating" active ingredients with its unique ring shape that is water-loving on the outside and oil-loving on the inside. This improves the stability and absorption of the product into the skin.

According to a manufacturer, it also offer some moisturizing effects.

This synthetic, signal peptide has unique skin conditioning properties in that is a matrikine-mimetic compound.

First of all, Palmitoyl Tripeptide-38 is a signal peptide; signal peptides tell the body to create more collagen.

What is a matrikine-mimetic compound?

This peptide has the ability to mimic matrikines in skin. Our skin created matrikines by breaking down matrix proteins into peptides.

Matrikines play a role in:

Though further research is needed, this ingredient seems pretty promising. In one study, women over the age of 40 with visible photoaging used a vitamin C serum with this ingredient for 56 days (15% ascorbid acid, 5 ppm palmitoyl tripeptide‐38). The results found improvement in skin roughness and skin tone.

This peptide is also part of the famous Matrixyl synthe’6, a blend of ingredients that also includes glycerin, water, and hydroxypropyl cyclodextrin.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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