Skin science article
Drunk Elephant Protini Powerpeptide Resurfacing Serum Versus Biossance Squalane + Glycolic Renewal Mask
Drunk Elephant Protini Powerpeptide Resurfacing Serum Versus Biossance Squalane + Glycolic Renewal Mask This smoothing serum is formulated around Lactic Acid and Sh-Oligopeptide-1 to refine skin texture and soften the look of wrinkles. This wash off mask is fo
Drunk Elephant Protini Powerpeptide Resurfacing Serum Versus Biossance Squalane + Glycolic Renewal Mask
This smoothing serum is formulated around Lactic Acid and Sh-Oligopeptide-1 to refine skin texture and soften the look of wrinkles.
This wash off mask is formulated around Glycolic Acid to exfoliate and smooth skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Lactic Acid
Dicaprylyl Carbonate
Squalane
Sodium Hydroxide
Glycine Max Seed Extract
Sclerocarya Birrea Seed Oil
Camellia Sinensis Seed Oil
Sodium PCA
Caprylic/Capric Triglyceride
Borago Officinalis Seed Oil
Tremella Fuciformis Polysaccharide
Tocotrienols
Sh-Oligopeptide-1
Sh-Oligopeptide-2
Sh-Polypeptide-1
Sh-Polypeptide-9
Sh-Polypeptide-11
Copper Palmitoyl Heptapeptide-14
Heptapeptide-15 Palmitate
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-1
Palmitoyl Tripeptide-38
Palmitoyl Hexapeptide-12
Tripeptide-1
Pyrus Malus Fruit Extract
Propanediol
Sodium Hyaluronate
Panthenol
Sodium Hyaluronate Crosspolymer
Sodium Lactate
PCA
Alanine
Arginine
Glycine
Histidine
Isoleucine
Phenylalanine
Proline
Serine
Threonine
Valine
Adenosine
Nymphaea Alba Root Extract
Bacillus/Folic Acid Ferment Filtrate Extract
Symphytum Officinale Callus Culture Extract
Dextran
Oryza Sativa Bran Oil
Linoleic Acid
Linolenic Acid
Butylene Glycol
Acetyl Glutamine
Coconut Alkanes
Coco-Caprylate/Caprate
Pentylene Glycol
Isomalt
Lecithin
Xanthan Gum
Aspartic Acid
Phytosphingosine
Phospholipids
Glycine Soja Sterols
Tocopherol
Citric Acid
Lactic Acid/Glycolic Acid Copolymer
Polyvinyl Alcohol
Phenoxyethanol
Sodium Benzoate
Hydroxypropyl Cyclodextrin
Polysorbate 20
Caprylyl Glycol
Phenylpropanol
Chlorphenesin
Carbomer
Glyceryl Caprylate
Ethylhexylglycerin
Water, Glycerin, Lactic Acid, Dicaprylyl Carbonate, Squalane, Sodium Hydroxide, Glycine Max Seed Extract, Sclerocarya Birrea Seed Oil, Camellia Sinensis Seed Oil, Sodium PCA, Caprylic/Capric Triglyceride, Borago Officinalis Seed Oil, Tremella Fuciformis Polysaccharide, Tocotrienols, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-38, Palmitoyl Hexapeptide-12, Tripeptide-1, Pyrus Malus Fruit Extract, Propanediol, Sodium Hyaluronate, Panthenol, Sodium Hyaluronate Crosspolymer, Sodium Lactate, PCA, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Adenosine, Nymphaea Alba Root Extract, Bacillus/Folic Acid Ferment Filtrate Extract, Symphytum Officinale Callus Culture Extract, Dextran, Oryza Sativa Bran Oil, Linoleic Acid, Linolenic Acid, Butylene Glycol, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate/Caprate, Pentylene Glycol, Isomalt, Lecithin, Xanthan Gum, Aspartic Acid, Phytosphingosine, Phospholipids, Glycine Soja Sterols, Tocopherol, Citric Acid, Lactic Acid/Glycolic Acid Copolymer, Polyvinyl Alcohol, Phenoxyethanol, Sodium Benzoate, Hydroxypropyl Cyclodextrin, Polysorbate 20, Caprylyl Glycol, Phenylpropanol, Chlorphenesin, Carbomer, Glyceryl Caprylate, Ethylhexylglycerin
Glycolic Acid
Stearyl Alcohol
Arachidyl Alcohol
Clay Mineral Oxides
Behenyl Alcohol
Capryloyl Glycerin/Sebacic Acid Copolymer
Vaccinium Myrtillus Fruit Extract
Saccharum Officinarum Extract
Acer Saccharum Extract
Kaolin
Diheptyl Succinate
Citrus Aurantium Dulcis Fruit Extract
Citrus Limon Fruit Extract
Tartaric Acid
Glycyrrhiza Glabra Root Extract
Citrus Limon Peel Oil
Montmorillonite
Illite
Acacia Senegal Gum
Biosaccharide Gum-1
Arachidyl Glucoside
Polyacrylate Crosspolymer-6
Sodium Phytate
Limonene
Water, Glycerin, Glycolic Acid, Squalane, Caprylic/Capric Triglyceride, Stearyl Alcohol, Arachidyl Alcohol, Clay Mineral Oxides, Behenyl Alcohol, Sodium Hydroxide, Lactic Acid, Pyrus Malus Fruit Extract, Capryloyl Glycerin/Sebacic Acid Copolymer, Vaccinium Myrtillus Fruit Extract, Saccharum Officinarum Extract, Acer Saccharum Extract, Kaolin, Sodium Hyaluronate, Xanthan Gum, Diheptyl Succinate, Citrus Aurantium Dulcis Fruit Extract, Citrus Limon Fruit Extract, Citric Acid, Tartaric Acid, Glycyrrhiza Glabra Root Extract, Citrus Limon Peel Oil, Montmorillonite, Illite, Acacia Senegal Gum, Biosaccharide Gum-1, Arachidyl Glucoside, Polyacrylate Crosspolymer-6, Phenoxyethanol, Ethylhexylglycerin, Sodium Phytate, Limonene
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Lactic Acid is another well-loved alpha hydroxy acid (AHA). It is gentler than glycolic acid but still highly effective.
Its main role is to exfoliate the surface of the skin by loosening the “glue” that holds dead skin cells together. Shedding those old cells leads to smoother, softer, and more even-toned skin.
Because lactic acid molecules are larger than glycolic acid, they don’t penetrate as deeply. This means they’re less likely to sting or irritate, making it a great choice for beginners or those with sensitive skin.
Like glycolic acid, it can:
Lactic acid also acts as a humectant (like hyaluronic acid). It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate.
Studies show it can boost ceramide production to strengthen the skin barrier and even help balance the skin’s microbiome.
To get results, choose products with a pH between 3-4.
Lower strengths (5-12%) focus on surface exfoliation; higher strengths (12% and up) can reach deeper in the dermis (deeper, supportive layer) to improve skin texture and firmness over time.
Though it was originally derived from milk, most modern lactic acid used in skincare is vegan. It is made through non-dairy fermentation to create a bio-identical and stable form suitable for all formulations.
When lactic acid shows up near the end of an ingredient list, it usually means the brand added just a tiny amount to adjust the product’s pH.
Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.
Lactic acid is truly a gentle multitasker: it exfoliates, hydrates, strengthens, and brightens. It's a great ingredient for giving your skin a smooth, glowing, and healthy look without the harshness of stronger acids.
Read more about some other popular AHA's here:
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Pyrus Malus Fruit Extract is extract from Apples. Apples are rich in Vitamin C, sugars, and antioxidants.
The sugar in Apples are humectants and help hydrate the skin. On top of that, apples also contain some acids, such as malic acid. These acids may have a mild exfoliating effect.
Last, the phytochemicals found in apples are strong antioxidants. These antioxidants help with anti-aging as they protect your skin cells against oxidative damage.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.