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Skin science article

Estée Lauder Advanced Night Repair Supercharged Eye Gel-Cream Versus Naturium Multi-Peptide Eye Cream

Estée Lauder Advanced Night Repair Supercharged Eye Gel-Cream Versus Naturium Multi-Peptide Eye Cream This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrinkles. Th

Estée Lauder Advanced Night Repair Supercharged Eye Gel-Cream Versus Naturium Multi-Peptide Eye Cream

This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrinkles.

This anti-aging eye moisturizer is formulated around Acetyl Hexapeptide-8 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dimethicone

Methyl Trimethicone

Bifida Ferment Lysate

Dimethicone/Vinyl Dimethicone Crosspolymer

Propanediol

Petrolatum

Sucrose

Glycerin

Butylene Glycol

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Trehalose

Tripeptide-32

Adansonia Digitata Seed Extract

Lavandula Angustifolia Flower Extract

Sodium Hyaluronate

Lactobacillus Ferment

Tocopheryl Acetate

Faex Extract

Hypnea Musciformis Extract

Sodium Rna

Caffeine

Squalane

Anthemis Nobilis Flower Oil

Poria Cocos Sclerotium Extract

Citrullus Lanatus Fruit Extract

Lens Esculenta Fruit Extract

Pyrus Malus Fruit Extract

Ethylhexylglycerin

Sodium PCA

Phytosphingosine

Hydrolyzed Algin

Hordeum Distichon Extract

Jojoba Esters

Triticum Vulgare Germ Oil

Hydrogenated Lecithin

Lecithin

Isohexadecane

Jojoba Alcohol

Isopropyl Jojobate

PEG/PPG-18/18 Dimethicone

Polysorbate 80

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Sorbitan Oleate

Sodium Lactate

Polysorbate 40

Potassium Gluconate

Tocopherol

BHT

Phenoxyethanol

Potassium Sorbate

Sodium Benzoate

CI 77491

CI 77492

Water, Dimethicone, Methyl Trimethicone, Bifida Ferment Lysate, Dimethicone/Vinyl Dimethicone Crosspolymer, Propanediol, Petrolatum, Sucrose, Glycerin, Butylene Glycol, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Trehalose, Tripeptide-32, Adansonia Digitata Seed Extract, Lavandula Angustifolia Flower Extract, Sodium Hyaluronate, Lactobacillus Ferment, Tocopheryl Acetate, Faex Extract, Hypnea Musciformis Extract, Sodium Rna, Caffeine, Squalane, Anthemis Nobilis Flower Oil, Poria Cocos Sclerotium Extract, Citrullus Lanatus Fruit Extract, Lens Esculenta Fruit Extract, Pyrus Malus Fruit Extract, Ethylhexylglycerin, Sodium PCA, Phytosphingosine, Hydrolyzed Algin, Hordeum Distichon Extract, Jojoba Esters, Triticum Vulgare Germ Oil, Hydrogenated Lecithin, Lecithin, Isohexadecane, Jojoba Alcohol, Isopropyl Jojobate, PEG/PPG-18/18 Dimethicone, Polysorbate 80, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Sorbitan Oleate, Sodium Lactate, Polysorbate 40, Potassium Gluconate, Tocopherol, BHT, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, CI 77491, CI 77492

Simmondsia Chinensis Seed Oil

Stearic Acid

Glyceryl Stearate

Cetyl Alcohol

Stearyl Alcohol

Palmitic Acid

Acetyl Hexapeptide-8

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-5

Dunaliella Salina Extract

Panthenol

Hydroxyacetophenone

Aluminum Starch Octenylsuccinate

1,2-Hexanediol

Boron Nitride

Caprylyl Glycol

Chlorphenesin

Sodium Hydroxide

Carbomer

Polysorbate 20

Citric Acid

Pantolactone

Water, Glycerin, Simmondsia Chinensis Seed Oil, Stearic Acid, Squalane, Glyceryl Stearate, Cetyl Alcohol, Stearyl Alcohol, Palmitic Acid, Acetyl Hexapeptide-8, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Dunaliella Salina Extract, Panthenol, Sodium Hyaluronate, Hydroxyacetophenone, Sorbitan Oleate, Aluminum Starch Octenylsuccinate, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Phenoxyethanol, Butylene Glycol, 1,2-Hexanediol, Boron Nitride, Caprylyl Glycol, Tocopheryl Acetate, Isohexadecane, Chlorphenesin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Hydroxide, Polysorbate 80, Carbomer, Sodium Lactate, Polysorbate 20, Citric Acid, Ethylhexylglycerin, Pantolactone, Sodium Benzoate, Potassium Sorbate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is a synthetic polymer used to stabilize formulas and give products a "gel-cream" feel.

When applied, this ingredient mostly stays on the surface of skin. Safety reviews have found these polymers safe in cosmetics when made to proper quality standards. Testing also shows they’re unlikely to cause irritation or sensitization at normal use levels.

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.

Due to its large size, Isohexadecane is not absorbed by the skin. Instead, it sits on top and acts as an emollient. Emollients help keep your skin soft and smooth by trapping moisture within.

Isohexadecane is often used in products designed to help oily skin. It is lightweight and non-greasy while helping to moisturize. When mixed with silicones, it gives a product a silky feel.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polysorbate 80 is a synthetic surfactant and emulsifier derived from sorbitol and oleic acid.

It reduces the surface tension between oil and water phases to help them stay mixed and stable in a formulation. In other words, it prevents your formulas from separating into an oily mess.

The CIR Expert Panel has evaluated the scientific data and found this ingredient to be safe, non-irritating, and non-sensitizing at concentrations up to 5% (it's even approved by the FDA as an OTC eye drop ingredient).

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and sometimes used to adjust the pH of a product.

This ingredient is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin. NMF also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.

High percentages of Sodium Lactate can have an exfoliating effect.

Fun fact: Sodium Lactate is produced from fermented sugar.

Sorbitan Oleate is a PEG-free emulsifier made by esterifying sorbitol with oleic acid.

You'll likely see it paired with Polysorbate 80 to create the right emulsification balance.

Typical use levels in formulas range from 2-10%.

The CIR Expert Panel has concluded this ingredient to be safe as a cosmetic ingredient.

Since this ingredient is an ester of oleic acid, it may not be fungal acne safe. Oleic acid is a fatty acid that falls into the C11-24 range that Malassezia can metabolize.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Water
  2. 02Glycerin
  3. 03Simmondsia Chinensis Seed Oil
  4. 04Stearic Acid
  5. 05Squalane
  6. 06Glyceryl Stearate
  7. 07Cetyl Alcohol
  8. 08Stearyl Alcohol
  9. 09Palmitic Acid
  10. 10Acetyl Hexapeptide-8
  11. 11Palmitoyl Tetrapeptide-7
  12. 12Palmitoyl Tripeptide-1
  13. 13Palmitoyl Tripeptide-5
  14. 14Dunaliella Salina Extract
  15. 15Panthenol
  16. 16Sodium Hyaluronate
  17. 17Hydroxyacetophenone
  18. 18Sorbitan Oleate
  19. 19Aluminum Starch Octenylsuccinate
  20. 20Acrylamide/Sodium Acryloyldimethyltaurate Copolymer
Source · skinsort.com
02

Product index

Related product references

Product

Naturium Multi-Peptide Eye Cream

Naturium Multi-Peptide Eye Cream Ingredients in Naturium Multi-Peptide Eye Cream explained: benefits, concerns, and detailed analysis of 39 ingredients including Water, Glycerin, and Simmon…

Source: skinsort.comView reference →

Product

naturium Multi-Peptide Eye Cream

naturium Multi-Peptide Eye Cream naturium Multi-Peptide Eye Cream ingredients explained: Aqua, Glycerin, Simmondsia Chinensis Seed Oil, Stearic Acid, Squalane, Glyceryl Stearate, Cetyl Alco…

Source: incidecoder.comView reference →

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naturium Multi-Peptide Eye Cream

naturium Multi-Peptide Eye Cream naturium Multi-Peptide Eye Cream ingredients explained: Water, Glycerin, Simmondsia Chinensis (Jojoba) Seed Oil, Stearic Acid, Squalane, Glyceryl Stearate, …

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side