Skin science article
First Aid Beauty Skin Rescue Daily Face Cream Versus La Roche-Posay Toleriane Dermallergo Ultra Soothing Repair Moisturizer
First Aid Beauty Skin Rescue Daily Face Cream Versus La Roche-Posay Toleriane Dermallergo Ultra Soothing Repair Moisturizer This barrier-repair day moisturizer is formulated around Squalane and Ceramide NP to strengthen the skin barrier and calm redness. This
First Aid Beauty Skin Rescue Daily Face Cream Versus La Roche-Posay Toleriane Dermallergo Ultra Soothing Repair Moisturizer
This barrier-repair day moisturizer is formulated around Squalane and Ceramide NP to strengthen the skin barrier and calm redness.
This barrier-repair moisturizer is formulated around Squalane and Butyrospermum Parkii Butter to strengthen the skin barrier and calm redness.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glyceryl Stearate Se
Glycerin
Squalane
Caprylic/Capric Triglyceride
Dimethicone
Cetearyl Alcohol
Cetyl Alcohol
Caprylyl Glycol
Carbomer
Chrysanthemum Parthenium Extract
Ceramide NP
Sodium Hydroxide
Camellia Sinensis Leaf Extract
Glycyrrhiza Glabra Root Extract
Phenoxyethanol
Water, Glyceryl Stearate Se, Glycerin, Squalane, Caprylic/Capric Triglyceride, Dimethicone, Cetearyl Alcohol, Cetyl Alcohol, Caprylyl Glycol, Carbomer, Chrysanthemum Parthenium Extract, Ceramide NP, Sodium Hydroxide, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra Root Extract, Phenoxyethanol
Isocetyl Stearate
Butyrospermum Parkii Butter
Zea Mays Starch
Pentylene Glycol
Butylene Glycol
Glyceryl Stearate
PEG-100 Stearate
Salvia Miltiorrhiza Root Extract
Dimethiconol
Sphingomonas Ferment Extract
Citric Acid
Acetyl Dipeptide-1 Cetyl Ester
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Water, Isocetyl Stearate, Squalane, Butyrospermum Parkii Butter, Dimethicone, Glycerin, Zea Mays Starch, Pentylene Glycol, Butylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Cetyl Alcohol, Salvia Miltiorrhiza Root Extract, Dimethiconol, Sodium Hydroxide, Sphingomonas Ferment Extract, Caprylyl Glycol, Citric Acid, Acetyl Dipeptide-1 Cetyl Ester, Acrylates/C10-30 Alkyl Acrylate Crosspolymer
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!