Skin science article
For Skin’s Sake (FSS) Retinal Eye Cream Versus MediCube PDRN Pink Peptide Eye Cream
For Skin’s Sake (FSS) Retinal Eye Cream Versus MediCube PDRN Pink Peptide Eye Cream This anti-aging eye moisturizer is formulated around Retinal and Caffeine to soften the look of wrinkles and refine skin texture. This anti-aging eye moisturizer is formulated
For Skin’s Sake (FSS) Retinal Eye Cream Versus MediCube PDRN Pink Peptide Eye Cream
This anti-aging eye moisturizer is formulated around Retinal and Caffeine to soften the look of wrinkles and refine skin texture.
This anti-aging eye moisturizer is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Caprylic/Capric Triglyceride
Glycerin
Propanediol
Sodium Acrylates Copolymer
Caffeine
Phenoxyethanol
Lecithin
Butylene Glycol
Squalane
Mica
Tocopheryl Acetate
Polysorbate 80
Retinal
Sucrose Laurate
1,2-Hexanediol
Acetyl Tetrapeptide-5
Water, Caprylic/Capric Triglyceride, Glycerin, Propanediol, Sodium Acrylates Copolymer, Caffeine, Phenoxyethanol, Lecithin, Butylene Glycol, Squalane, Mica, Tocopheryl Acetate, Polysorbate 80, Retinal, Sucrose Laurate, 1,2-Hexanediol, Acetyl Tetrapeptide-5
Dipropylene Glycol
Niacinamide
Pentaerythrityl Tetraethylhexanoate
Cetearyl Alcohol
Glycereth-26
Butylene Glycol Dicaprylate/Dicaprate
Bis-Behenyl/Isostearyl/Phytosteryl Dimer Dilinoleyl Dimer Dilinoleate
Cetearyl Olivate
Sorbitan Olivate
Propylene Glycol Dibenzoate
Pullulan
Glyceryl Stearate
Vinyldimethicone
Hydroxyacetophenone
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Hydrogenated Lecithin
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Sodium DNA
Polyisobutene
Ethylhexylglycerin
Melia Azadirachta Leaf Extract
Adenosine
Melia Azadirachta Flower Extract
Curcuma Longa Root Extract
Sorbitan Isostearate
Sorbitan Oleate
Caprylyl/Capryl Glucoside
Fragaria Chiloensis Fruit Extract
Hedera Helix Leaf/Stem Extract
Cyanocobalamin
Citrus Nobilis Peel Extract
Retinol
Ocimum Sanctum Leaf Extract
Lespedeza Capitata Leaf/Stem Extract
Corallina Officinalis Extract
Sodium Hyaluronate
Coffea Arabica Seed Extract
Hydrolyzed Extensin
Hydrolyzed Hyaluronic Acid
Copper Tripeptide-1
Sodium Acetylated Hyaluronate
Acetyl Hexapeptide-8
Palmitoyl Pentapeptide-4
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-1
Water, Glycerin, Dipropylene Glycol, Niacinamide, Caprylic/Capric Triglyceride, Pentaerythrityl Tetraethylhexanoate, Cetearyl Alcohol, Glycereth-26, Butylene Glycol Dicaprylate/Dicaprate, Bis-Behenyl/Isostearyl/Phytosteryl Dimer Dilinoleyl Dimer Dilinoleate, Cetearyl Olivate, Sorbitan Olivate, Propylene Glycol Dibenzoate, Pullulan, 1,2-Hexanediol, Glyceryl Stearate, Vinyldimethicone, Hydroxyacetophenone, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydrogenated Lecithin, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium DNA, Polyisobutene, Butylene Glycol, Ethylhexylglycerin, Propanediol, Melia Azadirachta Leaf Extract, Adenosine, Melia Azadirachta Flower Extract, Curcuma Longa Root Extract, Sorbitan Isostearate, Sorbitan Oleate, Caprylyl/Capryl Glucoside, Fragaria Chiloensis Fruit Extract, Hedera Helix Leaf/Stem Extract, Cyanocobalamin, Citrus Nobilis Peel Extract, Retinol, Ocimum Sanctum Leaf Extract, Lespedeza Capitata Leaf/Stem Extract, Corallina Officinalis Extract, Sodium Hyaluronate, Caffeine, Coffea Arabica Seed Extract, Hydrolyzed Extensin, Hydrolyzed Hyaluronic Acid, Copper Tripeptide-1, Sodium Acetylated Hyaluronate, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.
As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.
Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.
You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.
Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.
Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!