Global Beauty Care Smooth & Lift Collagen Facial Serum Versus Bliss Pro Multi-Peptide Youth Face Serum

Global Beauty Care Smooth & Lift Collagen Facial Serum Versus Bliss Pro Multi-Peptide Youth Face Serum

This anti-aging serum is formulated around Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8 to soften the look of wrinkles.

This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Squalane

Propylene Glycol

Hydrolyzed Collagen

Xanthan Gum

1,2-Hexanediol

Hyaluronic Acid

Oligopeptide-1

Palmitoyl Tripeptide-5

Acetyl Hexapeptide-8

Chlorphenesin

Allantoin

Hydroxyethylcellulose

Carbomer

Arginine

Phenoxyethanol

Caprylhydroxamic Acid

Butylene Glycol

Hydroxyacetophenone

Polysorbate 20

Disodium EDTA

Glyceryl Caprylate

Hydrolyzed Elastin

Ethylhexylglycerin

Water, Glycerin, Squalane, Propylene Glycol, Hydrolyzed Collagen, Xanthan Gum, 1,2-Hexanediol, Hyaluronic Acid, Oligopeptide-1, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Chlorphenesin, Allantoin, Hydroxyethylcellulose, Carbomer, Arginine, Phenoxyethanol, Caprylhydroxamic Acid, Butylene Glycol, Hydroxyacetophenone, Polysorbate 20, Disodium EDTA, Glyceryl Caprylate, Hydrolyzed Elastin, Ethylhexylglycerin

Propanediol

Polysilicone-11

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-38

Hexapeptide-9

Panthenol

Tocopherol

Tocopheryl Acetate

Plankton Extract

Hippophae Rhamnoides Fruit Extract

Lycium Barbarum Fruit Extract

Helianthus Annuus Seed Oil

Arginine Ferulate

Sodium Hyaluronate

Raspberry Ketone

Cetearyl Olivate

Ubiquinone

Diglycerin

Saccharide Isomerate

Caprylyl Glycol

Hydroxypropyl Cyclodextrin

C12-15 Alkyl Benzoate

Polyacrylate Crosspolymer-6

Polyglyceryl-4 Laurate/Succinate

Sorbitan Olivate

Laureth-12

Sodium Citrate

Potassium Sorbate

Citric Acid

Water, Propanediol, Glycerin, Polysilicone-11, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Acetyl Hexapeptide-8, Hexapeptide-9, Panthenol, Tocopherol, Tocopheryl Acetate, Plankton Extract, Hippophae Rhamnoides Fruit Extract, Lycium Barbarum Fruit Extract, Helianthus Annuus Seed Oil, Arginine Ferulate, Sodium Hyaluronate, Raspberry Ketone, Cetearyl Olivate, Ubiquinone, Diglycerin, Saccharide Isomerate, Caprylyl Glycol, Hydroxypropyl Cyclodextrin, C12-15 Alkyl Benzoate, Polyacrylate Crosspolymer-6, Polyglyceryl-4 Laurate/Succinate, Sorbitan Olivate, Carbomer, Polysorbate 20, Laureth-12, Butylene Glycol, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin, Potassium Sorbate, Citric Acid

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Palmitoyl Tripeptide-5 is a synthetic signal lipopeptide. This just means it is a three amino acid chain bolted onto a palmitic acid tail so it can slip through the skin's lipid barrier.

This peptide has a "build more, lose less" approach.

It's designed to mimic the collagen-stimulating activity in your skin by copying a snippet of one of your skin's own matrix proteins. This nudges fibroblasts into making more collagen while inhibiting the enzyme that breaks down skin protein.

The manufacturer's in vivo study of 45 volunteers found 1% and 2.5% reduced the appearance of wrinkles by 7% and 12% respectively, after using it twice daily for 84 days.

This is in the expected range for peptides; they're slow and cumulative actives and not overnight fixers.

Typical use levels range from 1-3% and this ingredient gets along with pretty much everything.

On the fungal acne front: Although palmitic acid sits in the chain length that Malassezia can feed on, this ingredient has it locked in an amine bond. This makes it hard for Malassezia to access as a source of food, and therefore fungal acne safe.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.

It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.

The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.

Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).

True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.

Because it is derived from lauric acid, it may not be fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons