Skin science article
Glossier Universal Pro-Retinol Versus Paula's Choice 1% Retinol Treatment
Glossier Universal Pro-Retinol Versus Paula's Choice 1% Retinol Treatment This anti-aging treatment is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. What's inside Key Ingredients Benefits Concer
Glossier Universal Pro-Retinol Versus Paula's Choice 1% Retinol Treatment
This anti-aging treatment is formulated around Retinol and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Propanediol
Cetyl Ethylhexanoate
C13-15 Alkane
Cetyl Alcohol
Butyrospermum Parkii Butter
Cetearyl Olivate
Coconut Alkanes
Sorbitan Olivate
Potassium Cetyl Phosphate
Betaine
Retinyl Sunflowerseedate
Stevia Rebaudiana Leaf/Stem Extract
Ophiopogon Japonicus Root Extract
Camellia Oleifera Leaf Extract
Aloe Barbadensis Leaf Juice
Sodium Hyaluronate
Tocopherol
Coco-Caprylate/Caprate
Ethylhexylglycerin
Glycol Stearate
Glyceryl Stearate
Caprylic/Capric Triglyceride
Maltodextrin
Xanthan Gum
Benzoic Acid
Sodium Hydroxide
Carbomer
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Trisodium Ethylenediamine Disuccinate
Water, Glycerin, Propanediol, Cetyl Ethylhexanoate, C13-15 Alkane, Cetyl Alcohol, Butyrospermum Parkii Butter, Cetearyl Olivate, Coconut Alkanes, Sorbitan Olivate, Potassium Cetyl Phosphate, Betaine, Retinyl Sunflowerseedate, Stevia Rebaudiana Leaf/Stem Extract, Ophiopogon Japonicus Root Extract, Camellia Oleifera Leaf Extract, Aloe Barbadensis Leaf Juice, Sodium Hyaluronate, Tocopherol, Coco-Caprylate/Caprate, Ethylhexylglycerin, Glycol Stearate, Glyceryl Stearate, Caprylic/Capric Triglyceride, Maltodextrin, Xanthan Gum, Benzoic Acid, Sodium Hydroxide, Carbomer, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Trisodium Ethylenediamine Disuccinate
Dimethicone
Butylene Glycol
Isononyl Isononanoate
Castor Isostearate Succinate
C12-15 Alkyl Benzoate
Dimethicone Crosspolymer
PEG-33
Polysorbate 20
Behenyl Alcohol
PEG-100 Stearate
Pentaerythrityl Tetraisostearate
Polymethylsilsesquioxane
Tetrahexyldecyl Ascorbate
Retinol
Ceramide Ng
Palmitoyl Tetrapeptide-7
Palmitoyl Hexapeptide-12
Dipotassium Glycyrrhizate
Glycyrrhiza Glabra Root Extract
Avena Sativa Kernel Extract
Arctium Lappa Seed Oil
Salix Alba Extract
Glycine Soja Sterols
Lecithin
Allantoin
Tocopheryl Acetate
Hydrolyzed Soy Protein
Sorbitan Laurate
Acetyl Dipeptide-1 Cetyl Ester
Disodium EDTA
Hydroxyethylcellulose
Palmitoyl Tripeptide-1
Tribehenin
Caprylyl Glycol
Pentylene Glycol
PEG-75 Shea Butter Glycerides
PPG-12/Smdi Copolymer
PEG-10 Phytosterol
PEG-8 Dimethicone
PEG-14
Magnesium Aluminum Silicate
Arachidyl Glucoside
Arachidyl Alcohol
Sclerotium Gum
Phenoxyethanol
Water, Dimethicone, Glycerin, Butylene Glycol, Isononyl Isononanoate, Castor Isostearate Succinate, Glyceryl Stearate, C12-15 Alkyl Benzoate, Dimethicone Crosspolymer, PEG-33, Polysorbate 20, Behenyl Alcohol, PEG-100 Stearate, Pentaerythrityl Tetraisostearate, Polymethylsilsesquioxane, Tetrahexyldecyl Ascorbate, Retinol, Ceramide Ng, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra Root Extract, Avena Sativa Kernel Extract, Arctium Lappa Seed Oil, Salix Alba Extract, Glycine Soja Sterols, Lecithin, Allantoin, Tocopheryl Acetate, Hydrolyzed Soy Protein, Sorbitan Laurate, Acetyl Dipeptide-1 Cetyl Ester, Disodium EDTA, Hydroxyethylcellulose, Palmitoyl Tripeptide-1, Sodium Hydroxide, Tribehenin, Caprylyl Glycol, Ethylhexylglycerin, Pentylene Glycol, PEG-75 Shea Butter Glycerides, PPG-12/Smdi Copolymer, PEG-10 Phytosterol, PEG-8 Dimethicone, PEG-14, Magnesium Aluminum Silicate, Arachidyl Glucoside, Arachidyl Alcohol, Sclerotium Gum, Carbomer, Phenoxyethanol, Benzoic Acid
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Benzoic Acid is an organic acid that shows up in cosmetics as a preservative. It helps keep a product from spoiling by holding back the growth of yeast, mold, and some bacteria.
This ingredient also functions as a fragrance ingredient that helps mask the unpleasant scent of other ingredients.
The way it works is worth understanding; benzoic acid works when the formula is acidic. It is able to sneak into a microbe's cell and mess up how it functions to stop it from growing in an acidic product.
However, the acid switches to an inactive form and stops working if a product isn't acidic enough (above ~5 pH). This is why you'll often see it in low pH products or teamed up with other preservatives to cover the gap.
Safety wise, it's one of the better studied preservatives out there.
The Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe for use in cosmetic formulations at concentrations up to 5%.
A large international review found this ingredient had no effects on the human body and had low irritation potential.
Just so you know, real world use is usually much lower than the 5% ceiling (usually 1% of less).
The EU caps it at 2.5% in rinse-off products, 1.7% in oral care, and 0.5% in leave-on products.
One thing worth mentioning (it's nothing to worry about): some people get a little stinging or flushing where they apply it. This isn't a true allergy; it's a temporary and harmless reaction. This is the same kind of mild tingle you might notice from sorbic acid.
Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!