Skin science article
hyphen Power Peptides Cocktail Serum Versus RAS Luxury Oils Collagen Boosting & Firming Advanced Booster Serum
hyphen Power Peptides Cocktail Serum Versus RAS Luxury Oils Collagen Boosting & Firming Advanced Booster Serum This anti-aging serum is formulated around Tripeptide-1 and Palmitoyl Pentapeptide-4 to soften the look of wrinkles and refine skin texture. This ant
hyphen Power Peptides Cocktail Serum Versus RAS Luxury Oils Collagen Boosting & Firming Advanced Booster Serum
This anti-aging serum is formulated around Tripeptide-1 and Palmitoyl Pentapeptide-4 to soften the look of wrinkles and refine skin texture.
This anti-aging serum is formulated around Copper Tripeptide-1 and Calendula Officinalis Flower Extract to soften the look of wrinkles and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
No concerns
Ingredients Side-by-side
Water
Propylene Glycol
Propanediol
Glycerin
Tripeptide-1
Hexapeptide-9
Palmitoyl Pentapeptide-4
Palmitoyl Tripeptide-1
Palmitoyl Tripeptide-5
Palmitoyl Tetrapeptide-7
Butylene Glycol
Panax Ginseng Extract
Trehalose
Copper Tripeptide-1
Acetyl Hexapeptide-8
Caprylyl Glycol
Xylitylglucoside
Anhydroxylitol
Sodium Hyaluronate
Linum Usitatissimum Seed Extract
Panthenol
Saccharide Isomerate
Xanthan Gum
Carbomer
Polysorbate 20
Citric Acid
Sodium Citrate
Phenoxyethanol
Ethylhexylglycerin
Water, Propylene Glycol, Propanediol, Glycerin, Tripeptide-1, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Butylene Glycol, Panax Ginseng Extract, Trehalose, Copper Tripeptide-1, Acetyl Hexapeptide-8, Caprylyl Glycol, Xylitylglucoside, Anhydroxylitol, Sodium Hyaluronate, Linum Usitatissimum Seed Extract, Panthenol, Saccharide Isomerate, Xanthan Gum, Carbomer, Polysorbate 20, Citric Acid, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin
Calendula Officinalis Flower Extract
Chamomilla Recutita Extract
Camellia Sinensis Extract
Aloe Barbadensis Leaf Extract
Bifida Ferment Lysate
Chondrus Crispus Extract
Hydrolyzed Hyaluronic Acid
Xylitol
Lecithin
Ectoin
Niacinamide
Acetyl Octapeptide-3
Cyamopsis Tetragonoloba Gum
Sodium Gluconate
Water, Calendula Officinalis Flower Extract, Chamomilla Recutita Extract, Camellia Sinensis Extract, Aloe Barbadensis Leaf Extract, Glycerin, Propanediol, Copper Tripeptide-1, Bifida Ferment Lysate, Chondrus Crispus Extract, Hydrolyzed Hyaluronic Acid, Citric Acid, Xylitylglucoside, Anhydroxylitol, Xylitol, Lecithin, Ectoin, Panthenol, Niacinamide, Acetyl Octapeptide-3, Caprylyl Glycol, Phenoxyethanol, Ethylhexylglycerin, Cyamopsis Tetragonoloba Gum, Sodium Gluconate
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
This ingredient is created from dehydrating xylitol in acidic conditions. Xylitol is a famous sugar and humectant.
Much like its predecessor, anhydroxylitol is a humectant. Humectants attract and hold water to moisturize the skin.
This ingredient is most commonly found in a popular trio called Aquaxyl. Aquaxyl is made up of anhydroxylitol (24 - 34%), xylitylglucoside (35 - 50%), and xylitol (5 - 15%).
According to a manufacturer, Aquaxyl is known for a 3-D hydration concept and an anti-dehydration shield to reinforce the outer layer of skin.
This ingredient is often derived from plants such as wood and sugarcane.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.
Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.
It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.
While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.
Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.
Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.
Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.
For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.
After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.
While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.
Read more about other common types of peptides here:
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xylitylglucoside is created from xylitol and glucose, two humectants.
Not surprisingly, this ingredient is also a humectant. It attracts and holds water in your skin, helping to maintain hydration.
This ingredient is most commonly found in a popular trio called Aquaxyl. Aquaxyl is made up of anhydroxylitol(24 - 34%), xylitylglucoside (35 - 50%), and xylitol (5 - 15%).