Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

innisfree Green Tea Balancing Cream Versus innisfree Collagen Peptide Firming Ampoule Cream

innisfree Green Tea Balancing Cream Versus innisfree Collagen Peptide Firming Ampoule Cream This oil-control moisturizer is formulated around Squalane and Niacinamide to balance excess oil and hydrate skin. This anti-aging moisturizer is formulated around Niac

innisfree Green Tea Balancing Cream Versus innisfree Collagen Peptide Firming Ampoule Cream

This oil-control moisturizer is formulated around Squalane and Niacinamide to balance excess oil and hydrate skin.

This anti-aging moisturizer is formulated around Niacinamide and Copper Tripeptide-1 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Propanediol

Cetyl Ethylhexanoate

Butylene Glycol

Methyl Trimethicone

Glycerin

Hydrogenated Poly(C6-14 Olefin)

C14-22 Alcohols

1,2-Hexanediol

Squalane

Niacinamide

Stearic Acid

Glyceryl Stearate

Betaine

Palmitic Acid

Arachidyl Alcohol

C12-20 Alkyl Glucoside

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Silica

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Behenyl Alcohol

Glyceryl Caprylate

Arachidyl Glucoside

Tromethamine

Disodium EDTA

Ethylhexylglycerin

Camellia Sinensis Leaf Extract

Sorbitan Isostearate

Arginine

Aspartic Acid

Glutamic Acid

Hyaluronic Acid

Zinc PCA

Gluconolactone

Glucose

Tocopherol

Water, Propanediol, Cetyl Ethylhexanoate, Butylene Glycol, Methyl Trimethicone, Glycerin, Hydrogenated Poly(C6-14 Olefin), C14-22 Alcohols, 1,2-Hexanediol, Squalane, Niacinamide, Stearic Acid, Glyceryl Stearate, Betaine, Palmitic Acid, Arachidyl Alcohol, C12-20 Alkyl Glucoside, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Silica, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Behenyl Alcohol, Glyceryl Caprylate, Arachidyl Glucoside, Tromethamine, Disodium EDTA, Ethylhexylglycerin, Camellia Sinensis Leaf Extract, Sorbitan Isostearate, Arginine, Aspartic Acid, Glutamic Acid, Hyaluronic Acid, Zinc PCA, Gluconolactone, Glucose, Tocopherol

Pentaerythrityl Tetraethylhexanoate

Dibutyl Adipate

Sucrose Polystearate

Sea Water

Dipalmitoyl Hydroxyproline

Cetearyl Alcohol

Glyceryl Stearate Citrate

Lactobacillus Ferment Lysate

Hydrogenated Polyisobutene

Xanthan Gum

Dextrin

Hydrolyzed Extensin

Simmondsia Chinensis Seed Oil

Pentylene Glycol

Sodium Metaphosphate

Glyceryl Caprylate/Caprate

Polyglyceryl-10 Laurate

Adenosine

Caprylyl Glycol

Artemisia Vulgaris Oil

Hydrogenated Lecithin

Theobroma Cacao Seed Extract

Sodium Hyaluronate

Santalum Album Oil

Mannitol

Achillea Millefolium Extract

Myristic Acid

Arachidic Acid

Glycine Max Polypeptide

Acrylates/Stearyl Methacrylate Copolymer

Hydrolyzed Hyaluronic Acid

Tremella Fuciformis Sporocarp Extract

Sodium Hyaluronate Crosspolymer

Copper Tripeptide-1

Acetyl Tetrapeptide-2

Acetyl Heptapeptide-4

Ceramide NP

Acetyl Tetrapeptide-11

Soluble Collagen

Sodium Acetylated Hyaluronate

Acetyl Hexapeptide-8

Sodium Hydroxide

Hexapeptide-9

Acetyl Octapeptide-3

Water, Glycerin, Butylene Glycol, Squalane, Methyl Trimethicone, Pentaerythrityl Tetraethylhexanoate, Dibutyl Adipate, Sucrose Polystearate, 1,2-Hexanediol, Glyceryl Stearate, Sea Water, Niacinamide, Dipalmitoyl Hydroxyproline, Cetearyl Alcohol, Glyceryl Stearate Citrate, Lactobacillus Ferment Lysate, Palmitic Acid, Hydrogenated Polyisobutene, Stearic Acid, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dextrin, Hyaluronic Acid, Hydrolyzed Extensin, Simmondsia Chinensis Seed Oil, Pentylene Glycol, Sodium Metaphosphate, Glyceryl Caprylate/Caprate, Polyglyceryl-10 Laurate, Tromethamine, Ethylhexylglycerin, Adenosine, Caprylyl Glycol, Artemisia Vulgaris Oil, Sorbitan Isostearate, Hydrogenated Lecithin, Theobroma Cacao Seed Extract, Sodium Hyaluronate, Santalum Album Oil, Propanediol, Mannitol, Achillea Millefolium Extract, Myristic Acid, Arachidic Acid, Glycine Max Polypeptide, Acrylates/Stearyl Methacrylate Copolymer, Hydrolyzed Hyaluronic Acid, Tremella Fuciformis Sporocarp Extract, Disodium EDTA, Sodium Hyaluronate Crosspolymer, Copper Tripeptide-1, Acetyl Tetrapeptide-2, Tocopherol, Acetyl Heptapeptide-4, Ceramide NP, Acetyl Tetrapeptide-11, Soluble Collagen, Sodium Acetylated Hyaluronate, Acetyl Hexapeptide-8, Sodium Hydroxide, Hexapeptide-9, Acetyl Octapeptide-3

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.

Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.

This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.

A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.

Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.

Fun fact: The human body also creates Glyceryl Stearate naturally.

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Methyl Trimethicone is a type of silicone. It is a solvent and emulsifier.

Solvents are used to keep ingredients together in a product. They can help dissolve ingredients to stable bases or help evenly distribute ingredients throughout the product.

Emulsifiers help stabilize a product. It does this by preventing certain ingredients from separating.

Methyl Trimethicone does not get absorbed into the skin.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Palmitic Acid is a fatty acid naturally found in our skin and in many plant and animal sources.

In cosmetics, it is usually derived from palm oil. It serves many purposes in skincare, acting as a cleanser, emollient, and emulsifier.

Interestingly, topically applied Palmitic Acid can be elongated into longer chain fatty acids and ceramides. A 2019 study found low levels of Palmitic Acid lead to slower development of cells, suggesting it plays a role in keeping your skin's renewal process on track.

The CIR (Cosmetic Ingredient Review) panel determined it safe as used in cosmetics at concentrations up to 13%. It is non-irritating and non-sensitizing in clinical studies.

The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Palmitic Acid, at C16, falls right into that sweet spot.

In vitro studies have shown that Palmitic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.

It's worth noting that what feeds yeast in a lab doesn't necessarily feed it on your face since formulation and your skin's chemistry play a bigger role.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.

As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.

In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.

Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Stearic Acid is a fatty acid that is already found in your skin. It's one of the free fatty acids that works alongside ceramides and cholesterols to maintain your barrier.

In cosmetics, it is a multitasker:

Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.

Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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