Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide Versus Clinique Smart Custom-Repair Serum

Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide Versus Clinique Smart Custom-Repair Serum

This anti-aging serum is formulated around Niacinamide and Ceramide NP to soften the look of wrinkles and refine skin texture.

This anti-aging serum is formulated around Ascorbyl Glucoside and Acetyl Hexapeptide-8 to soften the look of wrinkles and brighten dull-looking skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Pentylene Glycol

Niacinamide

Cetyl Alcohol

Isohexadecane

Isononyl Isononanoate

Diisopropyl Sebacate

2-Oleamido-1,3-Octadecanediol

4-T-Butylcyclohexanol

Acetyl Dipeptide-1 Cetyl Ester

Adenosine

Ceramide NP

Hydroxypalmitoyl Sphinganine

Lauroyl Lysine

Octyldodecanol

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Sodium Chloride

Sodium Hyaluronate

Sodium Hydroxide

Trisodium Ethylenediamine Disuccinate

Retinol

Tocopherol

Dicaprylyl Ether

Ammonium Polyacryloyldimethyl Taurate

Behenyl Alcohol

Caprylyl Glycol

Carbomer

Cetearyl Alcohol

Cetearyl Glucoside

Glycine Soja Oil

Helianthus Annuus Seed Oil

Hydroxyethylcellulose

Lecithin

Phenethyl Alcohol

Poloxamer 188

Polycaprolactone

Sorbitan Laurate

Steareth-100

CI 40800

Chlorphenesin

Phenoxyethanol

Water, Glycerin, Butylene Glycol, Pentylene Glycol, Niacinamide, Cetyl Alcohol, Isohexadecane, Isononyl Isononanoate, Diisopropyl Sebacate, 2-Oleamido-1,3-Octadecanediol, 4-T-Butylcyclohexanol, Acetyl Dipeptide-1 Cetyl Ester, Adenosine, Ceramide NP, Hydroxypalmitoyl Sphinganine, Lauroyl Lysine, Octyldodecanol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Chloride, Sodium Hyaluronate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Retinol, Tocopherol, Dicaprylyl Ether, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Caprylyl Glycol, Carbomer, Cetearyl Alcohol, Cetearyl Glucoside, Glycine Soja Oil, Helianthus Annuus Seed Oil, Hydroxyethylcellulose, Lecithin, Phenethyl Alcohol, Poloxamer 188, Polycaprolactone, Sorbitan Laurate, Steareth-100, CI 40800, Chlorphenesin, Phenoxyethanol

Isododecane

Dimethicone

Cyclopentasiloxane

Polysilicone-11

Ascorbyl Glucoside

PEG-10 Dimethicone

PEG-6

Citrus Grandis Peel Extract

Morus Nigra Root Extract

Hordeum Vulgare Extract

Scutellaria Baicalensis Root Extract

Cucumis Sativus Fruit Extract

Hydrolyzed Rice Bran Extract

Gentiana Lutea Root Extract

Algae Extract

Plankton Extract

Vitis Vinifera Fruit Extract

Sigesbeckia Orientalis Extract

Triticum Vulgare Germ Extract

Oryza Sativa Bran Extract

Faex Extract

Acetyl Hexapeptide-8

Palmitoyl Oligopeptide

Ergothioneine

Whey Protein

Polysorbate 20

Micrococcus Lysate

Cholesterol

Di-C12-18 Alkyl Dimonium Chloride

Salicylic Acid

Propylene Glycol Dicaprate

Helianthus Annuus Seedcake

Caffeine

Glycine Soja Protein

Tocopheryl Acetate

Acetyl Glucosamine

Glyceryl Polymethacrylate

Dimethoxytolyl Propylresorcinol

Synthetic Fluorphlogopite

Glycyrrhetinic Acid

Tromethamine

Polysorbate 80

Sodium Rna

Squalane

Aminopropyl Ascorbyl Phosphate

Ammonium Acryloyldimethyltaurate/Vp Copolymer

PEG-8

Hexylene Glycol

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Tin Oxide

Disodium EDTA

CI 19140

CI 14700

CI 77891

Palmitoyl Hexapeptide-12

Calcium Chloride

Sea Whip Extract

Water, Isododecane, Dimethicone, Cyclopentasiloxane, Polysilicone-11, Butylene Glycol, Ascorbyl Glucoside, PEG-10 Dimethicone, PEG-6, Citrus Grandis Peel Extract, Morus Nigra Root Extract, Hordeum Vulgare Extract, Scutellaria Baicalensis Root Extract, Cucumis Sativus Fruit Extract, Hydrolyzed Rice Bran Extract, Gentiana Lutea Root Extract, Algae Extract, Plankton Extract, Vitis Vinifera Fruit Extract, Sigesbeckia Orientalis Extract, Triticum Vulgare Germ Extract, Glycerin, Oryza Sativa Bran Extract, Faex Extract, Acetyl Hexapeptide-8, Palmitoyl Oligopeptide, Ergothioneine, Whey Protein, Polysorbate 20, Micrococcus Lysate, Cholesterol, Di-C12-18 Alkyl Dimonium Chloride, Salicylic Acid, Isohexadecane, Propylene Glycol Dicaprate, Helianthus Annuus Seedcake, Caffeine, Glycine Soja Protein, Tocopheryl Acetate, Acetyl Glucosamine, Caprylyl Glycol, Glyceryl Polymethacrylate, Dimethoxytolyl Propylresorcinol, Synthetic Fluorphlogopite, Glycyrrhetinic Acid, Tromethamine, Polysorbate 80, Sodium Hyaluronate, Sodium Rna, Squalane, Aminopropyl Ascorbyl Phosphate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, PEG-8, Lecithin, Hexylene Glycol, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Sodium Hydroxide, Tin Oxide, Disodium EDTA, Phenoxyethanol, CI 19140, CI 14700, CI 77891, Palmitoyl Hexapeptide-12, Calcium Chloride, Sea Whip Extract

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.

Due to its large size, Isohexadecane is not absorbed by the skin. Instead, it sits on top and acts as an emollient. Emollients help keep your skin soft and smooth by trapping moisture within.

Isohexadecane is often used in products designed to help oily skin. It is lightweight and non-greasy while helping to moisturize. When mixed with silicones, it gives a product a silky feel.

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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