KISOCare 20% Azelaic Acid Cream Versus APLB Azelaic Acid Peptide Facial Cream

KISOCare 20% Azelaic Acid Cream Versus APLB Azelaic Acid Peptide Facial Cream

This calming treatment is formulated around Azelaic Acid and Dipotassium Glycyrrhizate to calm redness and clear breakouts.

This calming moisturizer is formulated around Centella Asiatica Leaf Water and Azelaic Acid to calm redness and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Azelaic Acid

Glycerin

Butylene Glycol

Pentylene Glycol

Squalane

Glyceryl Stearate

Hydrogenated Lecithin

Dipotassium Glycyrrhizate

Sodium Hyaluronate

Centella Asiatica Extract

Scutellaria Baicalensis Root Extract

Polygonum Cuspidatum Root Extract

Glycyrrhiza Glabra Root Extract

Camellia Sinensis Leaf Extract

Rosmarinus Officinalis Leaf Extract

Chamomilla Recutita Flower Extract

Xanthan Gum

Ethylhexylglycerin

Tocopherol

Water, Azelaic Acid, Glycerin, Butylene Glycol, Pentylene Glycol, Squalane, Glyceryl Stearate, Hydrogenated Lecithin, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Centella Asiatica Extract, Scutellaria Baicalensis Root Extract, Polygonum Cuspidatum Root Extract, Glycyrrhiza Glabra Root Extract, Camellia Sinensis Leaf Extract, Rosmarinus Officinalis Leaf Extract, Chamomilla Recutita Flower Extract, Xanthan Gum, Ethylhexylglycerin, Tocopherol

Centella Asiatica Leaf Water

Cetyl Ethylhexanoate

Polyglyceryl-3 Methylglucose Distearate

Sh-Oligopeptide-1

Stearic Acid

Sodium Polyacryloyldimethyl Taurate

Hydrogenated Polydecene

Trideceth-10

Silica

Beeswax

Butyrospermum Parkii Butter

Macadamia Ternifolia Seed Oil

Betaine

Trehalose

Citric Acid

Nelumbo Nucifera Extract

Artemisia Annua Extract

Oryza Sativa Extract

Saccharomyces Ferment

Solanum Melongena Fruit Extract

Melaleuca Alternifolia Leaf Extract

Hydrolyzed Collagen

Beta-Glucan

Dipropylene Glycol

Hippophae Rhamnoides Fruit Extract

Madecassic Acid

Asiaticoside

Asiatic Acid

Disodium EDTA

Propanediol

Hydroxyacetophenone

1,2-Hexanediol

Water, Centella Asiatica Leaf Water, Glycerin, Cetyl Ethylhexanoate, Butylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Azelaic Acid, Sh-Oligopeptide-1, Sodium Hyaluronate, Stearic Acid, Sodium Polyacryloyldimethyl Taurate, Hydrogenated Polydecene, Trideceth-10, Silica, Glyceryl Stearate, Beeswax, Butyrospermum Parkii Butter, Macadamia Ternifolia Seed Oil, Betaine, Trehalose, Citric Acid, Nelumbo Nucifera Extract, Artemisia Annua Extract, Oryza Sativa Extract, Saccharomyces Ferment, Solanum Melongena Fruit Extract, Melaleuca Alternifolia Leaf Extract, Hydrolyzed Collagen, Squalane, Beta-Glucan, Dipropylene Glycol, Hippophae Rhamnoides Fruit Extract, Madecassic Acid, Asiaticoside, Asiatic Acid, Disodium EDTA, Propanediol, Hydroxyacetophenone, 1,2-Hexanediol, Ethylhexylglycerin, Dipotassium Glycyrrhizate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Azelaic acid is a multitasker ingredient that helps treat acne, pigmentation, and irritation. It is a great option for sensitive skin.

What makes it special?

OTC Azelaic acid is usually available in concentrations from 10-15% and anything over requires a prescription.

Here's what each tier does best:

Unlike other acids, azelaic acid will not make your skin more photosensitive/sun sensitive.

Though this ingredient is naturally occurring in grains like wheat, rye, and barley, it is usually synthetically created for cosmetics to ensure stability and effectiveness.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.

Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.

This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.

A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.

Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.

Fun fact: The human body also creates Glyceryl Stearate naturally.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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