La Roche-Posay Redermic R Eyes Anti-Aging Eye Cream with Retinol Versus Biossance Squalane + Peptide Eye Gel

La Roche-Posay Redermic R Eyes Anti-Aging Eye Cream with Retinol Versus Biossance Squalane + Peptide Eye Gel

This anti-aging eye moisturizer is formulated around Caffeine and Retinol to soften the look of wrinkles and refine skin texture.

This anti-aging eye moisturizer is formulated around Squalane and Niacinamide to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Isocetyl Stearate

Glycerin

Octyldodecanol

Propylene Glycol

Pentylene Glycol

Dimethicone

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Cetearyl Alcohol

Dimethicone/Vinyl Dimethicone Crosspolymer

Caffeine

Isohexadecane

Sodium Hyaluronate

Sodium Hydroxide

Retinol

Retinyl Linoleate

Adenosine

Ammonium Polyacryloyldimethyl Taurate

Caprylyl Glycol

Citric Acid

Polysilicone-8

Polysorbate 80

Phenoxyethanol

Water, Isocetyl Stearate, Glycerin, Octyldodecanol, Propylene Glycol, Pentylene Glycol, Dimethicone, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Cetearyl Alcohol, Dimethicone/Vinyl Dimethicone Crosspolymer, Caffeine, Isohexadecane, Sodium Hyaluronate, Sodium Hydroxide, Retinol, Retinyl Linoleate, Adenosine, Ammonium Polyacryloyldimethyl Taurate, Caprylyl Glycol, Citric Acid, Polysilicone-8, Polysorbate 80, Phenoxyethanol

Aloe Barbadensis Leaf Juice

Squalane

Niacinamide

Panthenol

Chondrus Crispus Extract

Malus Domestica Fruit Cell Culture Extract

Acetyl Tetrapeptide-5

Acetyl Hexapeptide-8

Tocopherol

Cucumis Sativus Fruit Extract

Tetrahexyldecyl Ascorbate

Camellia Sinensis Leaf Extract

Lycium Barbarum Fruit Extract

Lycopene

Vitis Vinifera Skin Extract

Acacia Senegal Gum

Dimethicone Crosspolymer

Xanthan Gum

Carbomer

Ethyl Lauroyl Arginate Hcl

Lecithin

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Silica

Potassium Sorbate

Water, Aloe Barbadensis Leaf Juice, Squalane, Niacinamide, Glycerin, Panthenol, Chondrus Crispus Extract, Malus Domestica Fruit Cell Culture Extract, Acetyl Tetrapeptide-5, Acetyl Hexapeptide-8, Tocopherol, Pentylene Glycol, Cucumis Sativus Fruit Extract, Tetrahexyldecyl Ascorbate, Camellia Sinensis Leaf Extract, Lycium Barbarum Fruit Extract, Lycopene, Vitis Vinifera Skin Extract, Sodium Hyaluronate, Caffeine, Acacia Senegal Gum, Dimethicone Crosspolymer, Xanthan Gum, Carbomer, Ethyl Lauroyl Arginate Hcl, Lecithin, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Silica, Phenoxyethanol, Potassium Sorbate, Citric Acid, Caprylyl Glycol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.

As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.

Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.

You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.

Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.

Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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