Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

La Roche-Posay Toleriane Hydrating Gentle Cleanser Versus Paula's Choice Resist Perfectly Balanced Foaming Cleanser

La Roche-Posay Toleriane Hydrating Gentle Cleanser Versus Paula's Choice Resist Perfectly Balanced Foaming Cleanser This cream cleanser uses mild cleansing ingredients, but contains alcohol that may feel drying for some. This mild cream cleanser is made to cle

La Roche-Posay Toleriane Hydrating Gentle Cleanser Versus Paula's Choice Resist Perfectly Balanced Foaming Cleanser

This cream cleanser uses mild cleansing ingredients, but contains alcohol that may feel drying for some.

This mild cream cleanser is made to cleanse without leaving your skin tight or dry.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Pentaerythrityl Tetraethylhexanoate

Propylene Glycol

Ammonium Polyacryloyldimethyl Taurate

Polysorbate 60

Ceramide NP

Niacinamide

Sodium Chloride

Coco-Betaine

Disodium EDTA

Caprylyl Glycol

Panthenol

T-Butyl Alcohol

Tocopherol

Water, Glycerin, Pentaerythrityl Tetraethylhexanoate, Propylene Glycol, Ammonium Polyacryloyldimethyl Taurate, Polysorbate 60, Ceramide NP, Niacinamide, Sodium Chloride, Coco-Betaine, Disodium EDTA, Caprylyl Glycol, Panthenol, T-Butyl Alcohol, Tocopherol

Sodium Lauroamphoacetate

Sodium Cocoyl Isethionate

Stearic Acid

Glycol Distearate

Helianthus Annuus Seed Oil

Acrylates Copolymer

Cetearyl Alcohol

Sodium Hyaluronate

Ceramide AP

Ceramide EOP

Phytosphingosine

Phospholipids

Sphingolipids

Lecithin

Arginine

Cholesterol

Aloe Barbadensis Leaf Extract

Sodium Hydroxide

Sodium Lauroyl Lactylate

Xanthan Gum

Carbomer

Hexylene Glycol

Phenoxyethanol

Water, Sodium Lauroamphoacetate, Sodium Cocoyl Isethionate, Stearic Acid, Glycerin, Glycol Distearate, Helianthus Annuus Seed Oil, Acrylates Copolymer, Cetearyl Alcohol, Sodium Hyaluronate, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Phospholipids, Sphingolipids, Lecithin, Arginine, Cholesterol, Aloe Barbadensis Leaf Extract, Disodium EDTA, Sodium Chloride, Sodium Hydroxide, Sodium Lauroyl Lactylate, Xanthan Gum, Carbomer, Hexylene Glycol, Phenoxyethanol, Caprylyl Glycol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Chances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt. This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.

You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.

You might see people debate whether Sodium Chloride is comedogenic, but there actually haven't been any comedogenic tests done on it. Either way, the overall formulation of a product matters a lot more than any single ingredient.

You might see this ingredient used in scrubs as a primary exfoliating ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Water
  2. 02Glycolic Acid
  3. 03Cyclopentasiloxane
  4. 04Dimethicone
  5. 05Glycerin
  6. 06Glyceryl Stearate
  7. 07Stearic Acid
  8. 08Cetyl Alcohol
  9. 09Butyrospermum Parkii Butter
  10. 10Sodium Hydroxide
  11. 11PEG-100 Stearate
  12. 12Tetrahexyldecyl Ascorbate
  13. 13Tocopheryl Acetate
  14. 14Chamomilla Recutita Flower Extract
  15. 15Vitis Vinifera Seed Oil
  16. 16Camellia Oleifera Leaf Extract
  17. 17Epilobium Angustifolium Extract
  18. 18Allantoin
  19. 19Butylene Glycol
  20. 20Xanthan Gum
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side