Skin science article
Laneige Retinol Firming Cream Treatment Versus Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide
Laneige Retinol Firming Cream Treatment Versus Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide This anti-aging treatment is formulated around Retinol and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture. This a
Laneige Retinol Firming Cream Treatment Versus Kiehl's Micro-Dose Anti-Aging Retinol Serum with Ceramides and Peptide
This anti-aging treatment is formulated around Retinol and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture.
This anti-aging serum is formulated around Niacinamide and Ceramide NP to soften the look of wrinkles and refine skin texture.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Caprylic/Capric Triglyceride
Butylene Glycol
Tocopherol
Tocopheryl Acetate
Methyl Trimethicone
Trehalose
Panthenol
Butyrospermum Parkii Butter
Cetearyl Alcohol
Polyglyceryl-10 Stearate
Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer
Hydrogenated Lecithin
Glycine Soja Oil
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Parfum
Carbomer
Tromethamine
Glyceryl Stearate
Sodium Sulfite
Allantoin
Glyceryl Caprylate
Gardenia Florida Fruit Extract
Stearic Acid
Polyglyceryl-3 Methylglucose Distearate
Palmitic Acid
Disodium EDTA
Ethylhexylglycerin
Retinol
Dextrin
Sorbitan Isostearate
Ceramide AP
1,2-Hexanediol
Madecassoside
Tranexamic Acid
Hedychium Coronarium Root Extract
BHT
Myristic Acid
Lauric Acid
Ascorbic Acid
Limnanthes Alba Seed Oil
Caprylyl Glycol
3-O-Ethyl Ascorbic Acid
Propanediol
Glutathione
Acetyl Heptapeptide-4
Sodium Hyaluronate
Hydrolyzed Hyaluronic Acid
Acetyl Hexapeptide-8
Sodium Hydroxide
Sodium Hyaluronate Crosspolymer
Hyaluronic Acid
Sodium Acetylated Hyaluronate
Acetyl Octapeptide-3
Water, Caprylic/Capric Triglyceride, Butylene Glycol, Tocopherol, Tocopheryl Acetate, Methyl Trimethicone, Trehalose, Panthenol, Butyrospermum Parkii Butter, Cetearyl Alcohol, Polyglyceryl-10 Stearate, Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer, Hydrogenated Lecithin, Glycine Soja Oil, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Parfum, Carbomer, Tromethamine, Glyceryl Stearate, Sodium Sulfite, Allantoin, Glyceryl Caprylate, Gardenia Florida Fruit Extract, Stearic Acid, Polyglyceryl-3 Methylglucose Distearate, Palmitic Acid, Disodium EDTA, Ethylhexylglycerin, Retinol, Dextrin, Sorbitan Isostearate, Ceramide AP, 1,2-Hexanediol, Madecassoside, Tranexamic Acid, Hedychium Coronarium Root Extract, BHT, Myristic Acid, Lauric Acid, Ascorbic Acid, Limnanthes Alba Seed Oil, Caprylyl Glycol, 3-O-Ethyl Ascorbic Acid, Propanediol, Glutathione, Acetyl Heptapeptide-4, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Acetyl Hexapeptide-8, Sodium Hydroxide, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Sodium Acetylated Hyaluronate, Acetyl Octapeptide-3
Glycerin
Pentylene Glycol
Niacinamide
Cetyl Alcohol
Isohexadecane
Isononyl Isononanoate
Diisopropyl Sebacate
2-Oleamido-1,3-Octadecanediol
4-T-Butylcyclohexanol
Acetyl Dipeptide-1 Cetyl Ester
Adenosine
Ceramide NP
Hydroxypalmitoyl Sphinganine
Lauroyl Lysine
Octyldodecanol
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Sodium Chloride
Trisodium Ethylenediamine Disuccinate
Dicaprylyl Ether
Ammonium Polyacryloyldimethyl Taurate
Behenyl Alcohol
Cetearyl Glucoside
Helianthus Annuus Seed Oil
Hydroxyethylcellulose
Lecithin
Phenethyl Alcohol
Poloxamer 188
Polycaprolactone
Sorbitan Laurate
Steareth-100
CI 40800
Chlorphenesin
Phenoxyethanol
Water, Glycerin, Butylene Glycol, Pentylene Glycol, Niacinamide, Cetyl Alcohol, Isohexadecane, Isononyl Isononanoate, Diisopropyl Sebacate, 2-Oleamido-1,3-Octadecanediol, 4-T-Butylcyclohexanol, Acetyl Dipeptide-1 Cetyl Ester, Adenosine, Ceramide NP, Hydroxypalmitoyl Sphinganine, Lauroyl Lysine, Octyldodecanol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Chloride, Sodium Hyaluronate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Retinol, Tocopherol, Dicaprylyl Ether, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Caprylyl Glycol, Carbomer, Cetearyl Alcohol, Cetearyl Glucoside, Glycine Soja Oil, Helianthus Annuus Seed Oil, Hydroxyethylcellulose, Lecithin, Phenethyl Alcohol, Poloxamer 188, Polycaprolactone, Sorbitan Laurate, Steareth-100, CI 40800, Chlorphenesin, Phenoxyethanol
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Glycine Soja Oil is a plant-derived oil from soybean seeds. Like other oils, it is rich in essential fatty acids (mostly linoleic and oleic) that support skin hydration and barrier function.
The fatty acids are able to integrate into the lipid matrix of the stratum corneum to help soften skin and reduce water loss.
On top of that, soybean oil is rich in vitamins like vitamin E, a potent antioxidant.
Research on soybean's active components also point to anti-inflammatory, collagen-stimulating, antioxidant activity, and protection against UV-induced oxidative damage.
Most of this research applies to the broader soybean plant and not just the oil fraction alone.
This ingredient may not be fungal acne safe due to the oleic acid content.
Retinol is one of the most studied anti-aging ingredients in skincare (and for good reason!).
It's a form of vitamin A that your skin converts into Retinoic Acid, the active molecule that actually does the work in your cells.
That conversion happens in two steps: your skin first turns Retinol into Retinaldehyde (also called Retinal), then turns Retinaldehyde into Retinoic Acid.
Retinol is converted to biologically active retinoic acid via retinaldehyde by dehydrogenases in a two-step oxidation process.
Each step is a little "upgrade" toward the active form which is part of why Retinol is gentler than prescription Retinoic Acid; your skin does the work gradually. This also explains where Retinol sits in the retinoid family.
Here is the retinoid family ranked roughly by strength: Retinyl Esters (like Retinyl Palmitate) < Retinol < Retinaldehyde < Retinoic Acid.
Retinoid activity increases in that order, while tolerance runs in reverse; retinyl esters are the gentlest and retinoic acid the most irritating.
The more conversion steps an ingredient needs, the gentler (and slower) it tends to be, so Retinol lands in a nice middle spot. It's more effective than the esters, gentler than prescription options.
Once it becomes Retinoic Acid, it binds to receptors inside your cells' nuclei (called RARs and RXRs). These receptor pairs bind to specific DNA motifs called retinoic acid response elements and act like switches that turn certain genes on or off.
In practice, this means a few things happen in a formula. It:
That last two are worth a closer look.
A study that tested Retinol directly (not just prescription Retinoic Acid) found that four weeks of retinol thickened the epidermis and switched on the genes for Collagen I and Collagen III, with more procollagen I and III showing up in the skin. And after twelve weeks, facial wrinkles were visibly reduced.
Retinoids more broadly stimulate the skin's synthesis of hyaluronan and other glycosaminoglycans, part of what gives skin a plumper, more hydrated look over time.
So even the gentler OTC form is doing real structural work (not just sitting on the surface).
It's also worth knowing Retinol isn't only a wrinkle ingredient; it can help with uneven tone, dark spots, rough texture, and the look of pores as well because it speeds up turnover and influences pigment.
The research backs this up as well.
A pooled analysis of six clinical studies found that 0.1% stabilized retinol improved all signs of photoaging versus vehicle as early as week 4 and through 12 weeks, with only a few mild cases of irritation.
Another study comparing concentrations found that 0.3% and 1% Retinol were similarly effective at remodeling photodamaged skin, but 0.3% caused fewer adverse reactions when used daily (a useful reminder that more isn't always better).
Retinol is about tenfold less potent than Retinoic Acid. This is why it works as a gentler, non-prescription option that builds results over time.
Typical concentrations range from 0.1-1%, with 0.1% to 0.3% being a well-supported sweet spot for visible benefits with good tolerability.
One quirk worth mentioning: Retinol is famously unstable.
It's highly sensitive to light and oxygen, and UV exposure breaks it down into a range of degradation products.
Real-world testing bears this out, with retinoid content in some products dropping anywhere from 0% to 80% after six months at room temperature, and even more at higher temperatures.
This is why good formulations lean on opaque, air-tight packaging (think tubes and pumps, not clear jars) and often "encapsulate" the Retinol to shield it.
Signs of oxidation include your product turning yellow or smelling "off". Keeping it somewhere cool and dark, and using it up within a few months of opening helps it stay effective.
The most common side effects are mild and temporary: usually some dryness, redness, or light peeling as your skin adjusts. These tend to settle with consistent and lower-frequency use.
Like all retinoids, Retinol works best with nightly use, a good moisturizer, and daytime sunscreen.
The "ramp up" method works well: start with Retinol once a week to give your skin time to adjust, which keeps irritation low. Slowly add more nights until you reach your goal frequency once your skin feels comfortable.
Retinoids also make your skin more sensitive to the sun in the first few weeks, so wear sunscreen every morning and protect your skin from direct sun while you build up tolerance.
One safety note: topical Retinoids aren't recommended during pregnancy or breastfeeding. Systemic absorption from creams is low but because high oral vitamin A is a known teratogen and topical safety data are limited, most clinicians recommend stopping retinoids when pregnant or trying to conceive.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!