Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Mario Badescu Protein Night Cream Versus Stratia Night Shift

Mario Badescu Protein Night Cream Versus Stratia Night Shift This night moisturizer is formulated around Oryza Sativa Bran Oil and Retinyl Palmitate to hydrate skin. This anti-aging night moisturizer is formulated around Retinol and Squalane to soften the look

Mario Badescu Protein Night Cream Versus Stratia Night Shift

This night moisturizer is formulated around Oryza Sativa Bran Oil and Retinyl Palmitate to hydrate skin.

This anti-aging night moisturizer is formulated around Retinol and Squalane to soften the look of wrinkles and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Petrolatum

Oryza Sativa Bran Oil

Glycerin

Ethylhexyl Palmitate

Cetyl Alcohol

C10-30 Cholesterol/Lanosterol Esters

Cera Alba

Dimethicone

Olus Oil

Stearic Acid

Propylene Glycol

Oligopeptide-5

Retinyl Palmitate

Soluble Collagen

Zea Mays Oil

Sodium Borate

Triethanolamine

Diazolidinyl Urea

Sodium Benzoate

Propylparaben

Methylparaben

Glyceryl Acrylate/Acrylic Acid Copolymer

Parfum

Phenoxyethanol

Tocopherol

Hexyl Cinnamal

Water, Petrolatum, Oryza Sativa Bran Oil, Glycerin, Ethylhexyl Palmitate, Cetyl Alcohol, C10-30 Cholesterol/Lanosterol Esters, Cera Alba, Dimethicone, Olus Oil, Stearic Acid, Propylene Glycol, Oligopeptide-5, Retinyl Palmitate, Soluble Collagen, Zea Mays Oil, Sodium Borate, Triethanolamine, Diazolidinyl Urea, Sodium Benzoate, Propylparaben, Methylparaben, Glyceryl Acrylate/Acrylic Acid Copolymer, Parfum, Phenoxyethanol, Tocopherol, Hexyl Cinnamal

Squalane

Sclerocarya Birrea Seed Oil

Hydrogenated Polydecene

Polyglyceryl-3 Methylglucose Distearate

Panthenol

Glyceryl Stearate

Hydrolyzed Centella Asiatica Extract

Retinol

Allantoin

Ceramide NP

Ceramide AP

Ceramide EOP

Phytosphingosine

Cholesterol

Sodium Lauroyl Lactylate

Carbomer

Copernicia Cerifera Cera

Propanediol

Sodium Cocoamphoacetate

Helianthus Annuus Seed Oil

Xanthan Gum

Humulus Lupulus Extract

Water, Glycerin, Squalane, Sclerocarya Birrea Seed Oil, Hydrogenated Polydecene, Polyglyceryl-3 Methylglucose Distearate, Panthenol, Glyceryl Stearate, Cetyl Alcohol, Stearic Acid, Dimethicone, Hydrolyzed Centella Asiatica Extract, Retinol, Allantoin, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Sodium Lauroyl Lactylate, Carbomer, Copernicia Cerifera Cera, Propanediol, Sodium Cocoamphoacetate, Helianthus Annuus Seed Oil, Tocopherol, Xanthan Gum, Humulus Lupulus Extract, Propylene Glycol, Diazolidinyl Urea, Methylparaben, Propylparaben

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

Its main roles are:

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.

Diazolidinyl Urea is an antimicrobial preservative. It is commonly used to prevent bacterial, yeast, and mold growth.

Diazolidinyl Urea slowly breaks down into formaldehyde, an effective microbe killer but also a known allergen/carcinogen.

Some people who are allergic to imidazolidinyl urea also react to diazolidinyl urea. It ranked as the 14th most common allergen in patch tests from 2005–06.

Safety reviews show that at concentrations under 0.5%, the formaldehyde released remains below the accepted safety limit, making it considered safe for cosmetic use.

Ultimately, its safety depends on individual skin sensitivity and personal comfort with formaldehyde-releasing preservatives.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Methylparaben is a synthetic preservative and one of the most widely used in the world. It has a simple, but important job: prevent your products from going bad by stopping bacteria, yeast, and mold from growing.

Typical use levels are low, often 0.1-0.3%.

This is also one of the most heavily studied preservatives out there and major regulatory bodies have repeatedly given it the green light.

In 2023, the EU's Scientific Committee on Consumer Safety (SCCS) confirmed that this ingredient is safe up to 0.4% on its own, of up to 0.8% when mixed with other paraben esters.

Here's the science behind the noise behind parabens/hormones as well:

Methylparaben shows very weak estrogen-like activity in vitro tests (more than 1,000x weaker than your body's own estradiol). In vivo (live-organism) studies don't support a meaningful endocrine-disrupting effect either.

You get a stronger estrogenic effect from eating tofu, actually.

It's also a low sensitizer and allergic reactions are uncommon; they usually happen on damage or broken skin.

There is a caveat: France has proposed to formally re-examine its endocrine classification in 2025 so the regulatory conversation isn't fully closed as of yet.

But as it stands today, this ingredient is considered safe at permitted levels.

Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.

As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.

The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.

True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).

It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.

Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.

Propylparaben is a preservative and one of the most widely used members of the paraben family (it's been used in cosmetics for over a century now).

It works by disrupting microbial cell membranes and enzymes, and is a broad-spectrum protector that works exceptionally well against molds, yeasts, and gram-positive bacteria.

You'll likely see it paired with methylparaben to cover the full range (including gram-negative bacteria).

This ingredient is effective at low concentrations (~0.2-0.5%) and stable across a wide pH range (4.5-7.5 pH). It's effectiveness drops off above pH 8 and it can lose potency when combined with non-ionic surfactants like polysorbate 80 due to micellization.

The regulatory bodies have concluded this ingredient to be safe as used in cosmetics. The EU has capped it at 0.14% and combined parabens are not to exceed 0.8%.

While parabens do cross the stratum corneum, only about 1% remains for absorption into the body. This is because most of it is metabolized within living skin.

Stearic Acid is a fatty acid that is already found in your skin. It's one of the free fatty acids that works alongside ceramides and cholesterols to maintain your barrier.

In cosmetics, it is a multitasker:

Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.

Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

02

Product index

Related product references

Product

Mario Badescu Protein Night Cream

Mario Badescu Protein Night Cream Ingredients in Mario Badescu Protein Night Cream explained: benefits, concerns, and detailed analysis of 27 ingredients including Water, Petrolatum, and Or…

Source: skinsort.comView reference →

Product

Mario Badescu Protein Night Cream

Mario Badescu Protein Night Cream Mario Badescu Protein Night Cream ingredients explained: Aqua (Water, Eau), Petrolatum, Oryza Sativa (Rice) Bran Oil, Glycerin, Ethylhexyl Palmitate, Cetyl…

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side