MEDI-PEEL Hyaluron Dark Benone Peptide 9 Ampoule Eye Patch Versus Dear, Klairs Fundamental Nourishing Eye Butter

MEDI-PEEL Hyaluron Dark Benone Peptide 9 Ampoule Eye Patch Versus Dear, Klairs Fundamental Nourishing Eye Butter

This anti-aging eye mask is formulated around Sodium Hyaluronate and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin.

This anti-aging eye moisturizer is formulated around Caffeine and Acetyl Hexapeptide-8 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Carrageenan

Butylene Glycol

Hydrolyzed Collagen

Sodium Hyaluronate

Hydrolyzed Hyaluronic Acid

Sodium Acetylated Hyaluronate

Hydroxypropyltrimonium Hyaluronate

Potassium Hyaluronate

Sodium Hyaluronate Crosspolymer

Hyaluronic Acid

Pearl Extract

Polysorbate 80

Tocopheryl Acetate

Ubiquinone

Acetyl Hexapeptide-8

Copper Tripeptide-1

Oligopeptide-29

Oligopeptide-32

Palmitoyl Pentapeptide-4

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Glyceryl Polymethacrylate

Propylene Glycol

Palmitoyl Oligopeptide

Palmitoyl Tripeptide-5

Propanediol

Pentylene Glycol

Cocos Nucifera Fruit Extract

Pinus Sylvestris Leaf Extract

Ricinus Communis Seed Oil

Butyrospermum Parkii Butter

Betaine

Allantoin

Dipotassium Glycyrrhizate

Ceratonia Siliqua Gum

Sucrose

Cyamopsis Tetragonoloba Gum

Cellulose Gum

Potassium Chloride

Calcium Chloride

Calcium Lactate

Caprylic/Capric Triglyceride

Sorbitan Caprylate

PEG-60 Hydrogenated Castor Oil

Diamond Powder

Titanium Dioxide

Oleth-10

Triethoxycaprylylsilane

Polysorbate 60

Simethicone

Methyl Methacrylate Crosspolymer

Aluminum Hydroxide

Synthetic Fluorphlogopite

Arginine

Disodium EDTA

Chlorphenesin

Ethyl Hexanediol

1,2-Hexanediol

Ethylhexylglycerin

Parfum

Water, Glycerin, Carrageenan, Butylene Glycol, Hydrolyzed Collagen, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Potassium Hyaluronate, Sodium Hyaluronate Crosspolymer, Hyaluronic Acid, Pearl Extract, Polysorbate 80, Tocopheryl Acetate, Ubiquinone, Acetyl Hexapeptide-8, Copper Tripeptide-1, Oligopeptide-29, Oligopeptide-32, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Glyceryl Polymethacrylate, Propylene Glycol, Palmitoyl Oligopeptide, Palmitoyl Tripeptide-5, Propanediol, Pentylene Glycol, Cocos Nucifera Fruit Extract, Pinus Sylvestris Leaf Extract, Ricinus Communis Seed Oil, Butyrospermum Parkii Butter, Betaine, Allantoin, Dipotassium Glycyrrhizate, Ceratonia Siliqua Gum, Sucrose, Cyamopsis Tetragonoloba Gum, Cellulose Gum, Potassium Chloride, Calcium Chloride, Calcium Lactate, Caprylic/Capric Triglyceride, Sorbitan Caprylate, PEG-60 Hydrogenated Castor Oil, Diamond Powder, Titanium Dioxide, Oleth-10, Triethoxycaprylylsilane, Polysorbate 60, Simethicone, Methyl Methacrylate Crosspolymer, Aluminum Hydroxide, Synthetic Fluorphlogopite, Arginine, Disodium EDTA, Chlorphenesin, Ethyl Hexanediol, 1,2-Hexanediol, Ethylhexylglycerin, Parfum

Stearic Acid

Helianthus Annuus Seed Oil

Caffeine

Phaseolus Angularis Seed Extract

Artemisia Princeps Leaf Extract

Camellia Sinensis Leaf Extract

Chaenomeles Sinensis Fruit Extract

Chrysanthellum Indicum Extract

Cinnamomum Cassia Bark Extract

Corallina Officinalis Extract

Curcuma Longa Root Extract

Diospyros Kaki Leaf Extract

Melia Azadirachta Flower Extract

Melia Azadirachta Leaf Extract

Ocimum Sanctum Leaf Extract

Panthenol

Pantolactone

Hydrogenated Lecithin

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Glyceryl Stearate

Sorbitan Isostearate

Cetearyl Alcohol

Arachidic Acid

Oleic Acid

Palmitic Acid

Caprylyl/Capryl Glucoside

Water, Glycerin, Stearic Acid, 1,2-Hexanediol, Helianthus Annuus Seed Oil, Betaine, Caffeine, Phaseolus Angularis Seed Extract, Artemisia Princeps Leaf Extract, Camellia Sinensis Leaf Extract, Chaenomeles Sinensis Fruit Extract, Chrysanthellum Indicum Extract, Cinnamomum Cassia Bark Extract, Corallina Officinalis Extract, Curcuma Longa Root Extract, Diospyros Kaki Leaf Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Ocimum Sanctum Leaf Extract, Acetyl Hexapeptide-8, Copper Tripeptide-1, Oligopeptide-29, Oligopeptide-32, Panthenol, Pantolactone, Hydrogenated Lecithin, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Hyaluronate, Glyceryl Stearate, Sorbitan Isostearate, Cetearyl Alcohol, Propanediol, Arachidic Acid, Oleic Acid, Palmitic Acid, Caprylyl/Capryl Glucoside, Ethylhexylglycerin

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.

Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.

Some studies suggest betaine may support making skin tone more even.

Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.

Betaine is also known as trimethylglycine.

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Oligopeptide-29 is an antioxidant and is a peptide.

Oligopeptide-32 is a peptide.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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