MediCube Deep Reviving Peptide Eye Cream Versus AXIS - Y Vegan Collagen Eye Serum

MediCube Deep Reviving Peptide Eye Cream Versus AXIS - Y Vegan Collagen Eye Serum

This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Tripeptide-5 to soften the look of wrinkles.

This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Pentapeptide-4 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Methylpropanediol

Glycerin

Cyclopentasiloxane

Butylene Glycol

Hydrogenated Poly(C6-14 Olefin)

Dipropylene Glycol

Caprylic/Capric Triglyceride

Panthenol

Niacinamide

Acetyl Hexapeptide-1

Palmitoyl Tripeptide-5

Acetyl Dipeptide-1 Cetyl Ester

Acetyl Octapeptide-3

Copper Tripeptide-1

Squalane

Glyceryl Stearate

Butyrospermum Parkii Butter

Polyglyceryl-3 Distearate

Cetearyl Olivate

C14-22 Alcohols

Stearyl Alcohol

Cetyl Alcohol

Sorbitan Olivate

Hydrogenated Lecithin

Polysorbate 60

Limnanthes Alba Seed Oil

Palmitic Acid

Stearic Acid

1,2-Hexanediol

C12-20 Alkyl Glucoside

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Dimethiconol

Ethylhexylglycerin

Sodium Stearoyl Glutamate

Saccharide Hydrolysate

Glyceryl Stearate Citrate

Fructooligosaccharides

Allantoin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Caprylyl Glycol

Pullulan

Dipotassium Glycyrrhizate

Saccharum Officinarum Extract

Adenosine

Sorbitan Laurate

Disodium EDTA

Sodium Hyaluronate

Hydroxyethylcellulose

Myristyl Alcohol

Myristic Acid

Hyaluronic Acid

Glucose

Arachidic Acid

Lauryl Alcohol

Sodium Hyaluronate Crosspolymer

Hydrolyzed Sodium Hyaluronate

Hydrolyzed Hyaluronic Acid

Ceramide NP

Atelocollagen

Desamido Collagen

Oleic Acid

Hydrolyzed Elastin

Hydrolyzed Collagen

Soluble Collagen

Sodium Acetylated Hyaluronate

Hydroxypropyltrimonium Hyaluronate

Collagen

Collagen Amino Acids

Procollagen

Magnesium PCA

Serine

Sucrose

Glycine

Calcium Chloride

Sea Salt

Alanine

Magnesium Chloride

Threonine

Histidine

Aspartic Acid

Valine

Proline

Dipotassium Phosphate

Lysine

Leucine

Tyrosine

Isoleucine

Magnesium Citrate

Glucosamine Hcl

Phenylalanine

Glutamic Acid

Arginine

1-Methylhydantoin-2-Imide

Asparagine

Citrulline

Methionine

Taurine

Tryptophan

Formic Acid

Glutamine

Cysteine

Parfum

Alpha-Isomethyl Ionone

Water, Methylpropanediol, Glycerin, Cyclopentasiloxane, Butylene Glycol, Hydrogenated Poly(C6-14 Olefin), Dipropylene Glycol, Caprylic/Capric Triglyceride, Panthenol, Niacinamide, Acetyl Hexapeptide-1, Palmitoyl Tripeptide-5, Acetyl Dipeptide-1 Cetyl Ester, Acetyl Octapeptide-3, Copper Tripeptide-1, Squalane, Glyceryl Stearate, Butyrospermum Parkii Butter, Polyglyceryl-3 Distearate, Cetearyl Olivate, C14-22 Alcohols, Stearyl Alcohol, Cetyl Alcohol, Sorbitan Olivate, Hydrogenated Lecithin, Polysorbate 60, Limnanthes Alba Seed Oil, Palmitic Acid, Stearic Acid, 1,2-Hexanediol, C12-20 Alkyl Glucoside, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Dimethiconol, Ethylhexylglycerin, Sodium Stearoyl Glutamate, Saccharide Hydrolysate, Glyceryl Stearate Citrate, Fructooligosaccharides, Allantoin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Caprylyl Glycol, Pullulan, Dipotassium Glycyrrhizate, Saccharum Officinarum Extract, Adenosine, Sorbitan Laurate, Disodium EDTA, Sodium Hyaluronate, Hydroxyethylcellulose, Myristyl Alcohol, Myristic Acid, Hyaluronic Acid, Glucose, Arachidic Acid, Lauryl Alcohol, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Ceramide NP, Atelocollagen, Desamido Collagen, Oleic Acid, Hydrolyzed Elastin, Hydrolyzed Collagen, Soluble Collagen, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Collagen, Collagen Amino Acids, Procollagen, Magnesium PCA, Serine, Sucrose, Glycine, Calcium Chloride, Sea Salt, Alanine, Magnesium Chloride, Threonine, Histidine, Aspartic Acid, Valine, Proline, Dipotassium Phosphate, Lysine, Leucine, Tyrosine, Isoleucine, Magnesium Citrate, Glucosamine Hcl, Phenylalanine, Glutamic Acid, Arginine, 1-Methylhydantoin-2-Imide, Asparagine, Citrulline, Methionine, Taurine, Tryptophan, Formic Acid, Glutamine, Cysteine, Parfum, Alpha-Isomethyl Ionone

Tripeptide-1

Palmitoyl Pentapeptide-4

Hexapeptide-9

Acetyl Hexapeptide-8

Pyrus Malus Fruit Extract

Prunus Mume Fruit Extract

Vitis Vinifera Fruit Extract

Helianthus Annuus Seed Oil

Simmondsia Chinensis Seed Oil

Carica Papaya Fruit Extract

Centella Asiatica Extract

Ficus Carica Fruit Extract

Ulmus Davidiana Root Extract

Amaranthus Caudatus Seed Extract

Leuconostoc/Radish Root Ferment Filtrate

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

C13-14 Alkane

Sodium Acrylic Acid/Ma Copolymer

C15-23 Alkane

Decyl Glucoside

Polyglyceryl-10 Stearate

Tocopherol

Water, Methylpropanediol, Glycerin, 1,2-Hexanediol, Niacinamide, Adenosine, Collagen, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Tripeptide-1, Palmitoyl Pentapeptide-4, Hexapeptide-9, Acetyl Hexapeptide-8, Copper Tripeptide-1, Pyrus Malus Fruit Extract, Prunus Mume Fruit Extract, Vitis Vinifera Fruit Extract, Helianthus Annuus Seed Oil, Simmondsia Chinensis Seed Oil, Limnanthes Alba Seed Oil, Carica Papaya Fruit Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Ceramide NP, Hydrogenated Lecithin, Leuconostoc/Radish Root Ferment Filtrate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, C13-14 Alkane, Sodium Acrylic Acid/Ma Copolymer, C15-23 Alkane, Ethylhexylglycerin, Decyl Glucoside, Caprylyl Glycol, Polyglyceryl-10 Stearate, Tocopherol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Collagen is a big structural protein that your body uses to keep skin firm and bouncy. Despite the marketing, topically applied collagen doesn't "refill" the collagen in your skin.

The molecule is too big to pass through your skin barrier so intact Collagen physically can't get past the surface.

What it actually does in your skincare is work as a humectant and film-former: it binds water, lays down a light moisturizing film, and reduces water loss from the surface. This helps make skin feel smoother and temporarily plumper.

This ingredient has been found safe for use in cosmetics with clinical studies showing no irritation, sensitization, or phototoxicity. It's typically used at low concentrations (often a fraction of a percent up to a few percent).

Collagen will not increase sun sensitivity, but you should always wear sunscreen during the day.

Learn more about hydrolyzed collagen or soluble collagen.

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

Limnanthes Alba Seed Oil is from the seeds of the meadowfoam plant. It is a skin conditioning agent and emollient that sits on top of skin to soften and hydrate it.

Over 98% of the oil is made up of long-chain fatty acids, mostly aachidic acid (61%), docosenoic acid (~16%), and docosadienoic acid (~18%).

This combination is not really found in any other plant oil and is the reason this is one of the most stable botanical oils available.

Some studies show it to be more stable than jojoba oil, helps a product resist going rancid, and can help extend the shelf life of a formula.

It also naturally contains vitamin E and phytosterols that give it a mild antioxidant benefit.

This ingredient is typically used from around 1% to fairly high levels since it's gentle; it's well-tolerated and low on the irritation scale.

Methylpropanediol is a synthetic solvent and humectant.

As a solvent, it helps dissolve other ingredients, helping to evenly distribute ingredients throughout the product. This ingredient has also been shown to have antimicrobial properties which makes it a preservative booster.

Methylpropanediol is able to add a bit of moisture to the skin. It also helps other ingredients be better absorbed into the skin, such as salicylic acid.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Sodium Acetylated Hyaluronate is a type of Hyaluronic Acid.

Hyaluronic Acids help moisturize, soothe, and protect the skin.

Read about common types of Hyaluronic Acid here:

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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