MediCube Deep Reviving Peptide Eye Cream Versus MEDI-PEEL Eye Tox Cream

MediCube Deep Reviving Peptide Eye Cream Versus MEDI-PEEL Eye Tox Cream

This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Tripeptide-5 to soften the look of wrinkles.

This anti-aging eye moisturizer is formulated around Urea and Adenosine to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Methylpropanediol

Glycerin

Cyclopentasiloxane

Butylene Glycol

Hydrogenated Poly(C6-14 Olefin)

Dipropylene Glycol

Caprylic/Capric Triglyceride

Panthenol

Niacinamide

Acetyl Hexapeptide-1

Palmitoyl Tripeptide-5

Acetyl Dipeptide-1 Cetyl Ester

Acetyl Octapeptide-3

Copper Tripeptide-1

Squalane

Glyceryl Stearate

Butyrospermum Parkii Butter

Polyglyceryl-3 Distearate

Cetearyl Olivate

C14-22 Alcohols

Stearyl Alcohol

Cetyl Alcohol

Sorbitan Olivate

Hydrogenated Lecithin

Polysorbate 60

Limnanthes Alba Seed Oil

Palmitic Acid

Stearic Acid

1,2-Hexanediol

C12-20 Alkyl Glucoside

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Dimethiconol

Ethylhexylglycerin

Sodium Stearoyl Glutamate

Saccharide Hydrolysate

Glyceryl Stearate Citrate

Fructooligosaccharides

Allantoin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Caprylyl Glycol

Pullulan

Dipotassium Glycyrrhizate

Saccharum Officinarum Extract

Adenosine

Sorbitan Laurate

Disodium EDTA

Sodium Hyaluronate

Hydroxyethylcellulose

Myristyl Alcohol

Myristic Acid

Hyaluronic Acid

Glucose

Arachidic Acid

Lauryl Alcohol

Sodium Hyaluronate Crosspolymer

Hydrolyzed Sodium Hyaluronate

Hydrolyzed Hyaluronic Acid

Ceramide NP

Atelocollagen

Desamido Collagen

Oleic Acid

Hydrolyzed Elastin

Hydrolyzed Collagen

Soluble Collagen

Sodium Acetylated Hyaluronate

Hydroxypropyltrimonium Hyaluronate

Collagen

Collagen Amino Acids

Procollagen

Magnesium PCA

Serine

Sucrose

Glycine

Calcium Chloride

Sea Salt

Alanine

Magnesium Chloride

Threonine

Histidine

Aspartic Acid

Valine

Proline

Dipotassium Phosphate

Lysine

Leucine

Tyrosine

Isoleucine

Magnesium Citrate

Glucosamine Hcl

Phenylalanine

Glutamic Acid

Arginine

1-Methylhydantoin-2-Imide

Asparagine

Citrulline

Methionine

Taurine

Tryptophan

Formic Acid

Glutamine

Cysteine

Parfum

Alpha-Isomethyl Ionone

Water, Methylpropanediol, Glycerin, Cyclopentasiloxane, Butylene Glycol, Hydrogenated Poly(C6-14 Olefin), Dipropylene Glycol, Caprylic/Capric Triglyceride, Panthenol, Niacinamide, Acetyl Hexapeptide-1, Palmitoyl Tripeptide-5, Acetyl Dipeptide-1 Cetyl Ester, Acetyl Octapeptide-3, Copper Tripeptide-1, Squalane, Glyceryl Stearate, Butyrospermum Parkii Butter, Polyglyceryl-3 Distearate, Cetearyl Olivate, C14-22 Alcohols, Stearyl Alcohol, Cetyl Alcohol, Sorbitan Olivate, Hydrogenated Lecithin, Polysorbate 60, Limnanthes Alba Seed Oil, Palmitic Acid, Stearic Acid, 1,2-Hexanediol, C12-20 Alkyl Glucoside, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Dimethiconol, Ethylhexylglycerin, Sodium Stearoyl Glutamate, Saccharide Hydrolysate, Glyceryl Stearate Citrate, Fructooligosaccharides, Allantoin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Caprylyl Glycol, Pullulan, Dipotassium Glycyrrhizate, Saccharum Officinarum Extract, Adenosine, Sorbitan Laurate, Disodium EDTA, Sodium Hyaluronate, Hydroxyethylcellulose, Myristyl Alcohol, Myristic Acid, Hyaluronic Acid, Glucose, Arachidic Acid, Lauryl Alcohol, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Ceramide NP, Atelocollagen, Desamido Collagen, Oleic Acid, Hydrolyzed Elastin, Hydrolyzed Collagen, Soluble Collagen, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Collagen, Collagen Amino Acids, Procollagen, Magnesium PCA, Serine, Sucrose, Glycine, Calcium Chloride, Sea Salt, Alanine, Magnesium Chloride, Threonine, Histidine, Aspartic Acid, Valine, Proline, Dipotassium Phosphate, Lysine, Leucine, Tyrosine, Isoleucine, Magnesium Citrate, Glucosamine Hcl, Phenylalanine, Glutamic Acid, Arginine, 1-Methylhydantoin-2-Imide, Asparagine, Citrulline, Methionine, Taurine, Tryptophan, Formic Acid, Glutamine, Cysteine, Parfum, Alpha-Isomethyl Ionone

Cetearyl Alcohol

Polyglyceryl-3 Methylglucose Distearate

Urea

C12-15 Alkyl Benzoate

Hydroxyacetophenone

Carbomer

Triethanolamine

Dimethicone

Betaine

Propanediol

Macadamia Ternifolia Seed Oil

Pvp

Camellia Sinensis Leaf Extract

Lavandula Angustifolia Extract

Rosmarinus Officinalis Leaf Extract

Acetyl Hexapeptide-8

Aloe Barbadensis Leaf Juice

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Scutellaria Baicalensis Root Extract

Aloe Barbadensis Leaf Extract

Bioflavonoids

Brassica Oleracea Italica Extract

Sh-Oligopeptide-1

Sh-Oligopeptide-2

Sh-Polypeptide-1

Sh-Polypeptide-16

Sh-Polypeptide-3

Water, Butylene Glycol, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Glycerin, Stearic Acid, Polyglyceryl-3 Methylglucose Distearate, Cyclopentasiloxane, Urea, C12-15 Alkyl Benzoate, Glyceryl Stearate, Hydroxyacetophenone, Carbomer, Triethanolamine, Dimethicone, Betaine, Propanediol, Macadamia Ternifolia Seed Oil, Limnanthes Alba Seed Oil, Ethylhexylglycerin, Panthenol, Pvp, Adenosine, Disodium EDTA, Camellia Sinensis Leaf Extract, Lavandula Angustifolia Extract, Rosmarinus Officinalis Leaf Extract, Sodium Hyaluronate, Acetyl Hexapeptide-8, Aloe Barbadensis Leaf Juice, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Hydrolyzed Collagen, Scutellaria Baicalensis Root Extract, 1,2-Hexanediol, Aloe Barbadensis Leaf Extract, Bioflavonoids, Brassica Oleracea Italica Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-16, Sh-Polypeptide-3

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Cyclopentasiloxane (D5) is a lightweight silicone that mostly acts as an emollient and solvent in cosmetics. Its the reason your products feel silky, fast-spreading, and non-greasy.

Since D5 is volatile, it does its thing and then evaporates off the skin quickly.

The safety profile of this ingredient is reassuring; the US CIR Expert Panel concluded D5 is safe as used in cosmetics and Health Canada concluded that D5 is not harmful to human health or the environment as currently used in cosmetics

There's a study that people mention about D5 in a rat study showing tumors. This study is related to long-term inhalation of high D5 levels.

Regulatory bodies have judged this study to be not applicable in topical skincare since skin absorption of D5 is very low and we're not really inhaling huge amounts of D5.

The only restriction for this ingredient is environmental. The European Chemicals Agency (ECHA) restricted D5 in wash-off cosmetics at or above 0.1% due to their persistence in water.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.

Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.

This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.

A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.

Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.

Fun fact: The human body also creates Glyceryl Stearate naturally.

Hydrolyzed Collagen is Collagen (usually sourced from fish, bovine, or porcine byproducts) that's been broken down into smaller peptides. This makes it water-soluble and easy to blend into formulations.

In a formula, it works mainly as a skin-conditioning and moisturizing agent.

The small peptides and amino acids (including Natural Moisturizing Factor components like Hydroxyproline, Serine, and Aspartic Acid) help the surface of the skin hold onto water, feel softer, and look temporarily plumper.

This ingredient also has mild film-forming and antioxidant properties with research showing the antioxidant effect is stronger the lower the molecular weight of the peptides.

It's worth being realistic here:

Topically applied Hydrolyzed Collagen conditions the upper layers of skin rather than rebuilding the structural collagen deep in your dermis (the wrinkle-and-firmness benefits people associate with Collagen mostly come from oral supplements in studies, not topicals).

However, recent lab and skin-model work on Hydrolyzed Fish Collagen has shown promising effects on cell viability and wound healing when used as an active.

Typical concentrations range from 0.2-2%, but the percentage can go much higher in rinse-off or hair products (sometimes even above 50%).

Clinical studies on this ingredient showed no irritation, sensitization, or phototoxicity.

If you are looking for vegan collagen, it usually goes by a different INCI name like hydrolyzed soy protein. Vegan collagen is derived from yeast, bacteria, or plant sources.

The results are varied.

A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.

However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.

Further studies are needed at this time.

Limnanthes Alba Seed Oil is from the seeds of the meadowfoam plant. It is a skin conditioning agent and emollient that sits on top of skin to soften and hydrate it.

Over 98% of the oil is made up of long-chain fatty acids, mostly aachidic acid (61%), docosenoic acid (~16%), and docosadienoic acid (~18%).

This combination is not really found in any other plant oil and is the reason this is one of the most stable botanical oils available.

Some studies show it to be more stable than jojoba oil, helps a product resist going rancid, and can help extend the shelf life of a formula.

It also naturally contains vitamin E and phytosterols that give it a mild antioxidant benefit.

This ingredient is typically used from around 1% to fairly high levels since it's gentle; it's well-tolerated and low on the irritation scale.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Stearic Acid is a fatty acid that is already found in your skin. It's one of the free fatty acids that works alongside ceramides and cholesterols to maintain your barrier.

In cosmetics, it is a multitasker:

Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.

Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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