Skin science article
MediCube Triple Collagen Serum Versus Naturium Alpha Arbutin Serum 2%
MediCube Triple Collagen Serum Versus Naturium Alpha Arbutin Serum 2% This anti-aging serum is formulated around Niacinamide and Adenosine to soften the look of wrinkles. This brightening serum is formulated around Alpha-Arbutin and Niacinamide to fade the loo
MediCube Triple Collagen Serum Versus Naturium Alpha Arbutin Serum 2%
This anti-aging serum is formulated around Niacinamide and Adenosine to soften the look of wrinkles.
This brightening serum is formulated around Alpha-Arbutin and Niacinamide to fade the look of dark spots and brighten dull-looking skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Sea Water
Glycerin
Butylene Glycol
Cetyl Ethylhexanoate
1,2-Hexanediol
Alcohol Denat.
Niacinamide
Glycereth-26
Adenosine
Hydrolyzed Collagen
Hyaluronic Acid
Hydrolyzed Hyaluronic Acid
Sodium Hyaluronate
Soluble Collagen
Collagen Extract
Atelocollagen
Propanediol
Cyclopentasiloxane
Trehalose
Carbomer
Cetearyl Olivate
Tromethamine
Cyclohexasiloxane
Sorbitan Olivate
Ethylhexylglycerin
Disodium EDTA
Dimethicone
Parfum
Sea Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, 1,2-Hexanediol, Alcohol Denat., Niacinamide, Glycereth-26, Adenosine, Hydrolyzed Collagen, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Soluble Collagen, Collagen Extract, Atelocollagen, Propanediol, Cyclopentasiloxane, Trehalose, Carbomer, Cetearyl Olivate, Tromethamine, Cyclohexasiloxane, Sorbitan Olivate, Ethylhexylglycerin, Disodium EDTA, Dimethicone, Parfum
Water
Alpha-Arbutin
Hydroxyacetophenone
Citrus Limon Fruit Extract
Polyacrylate Crosspolymer-6
Panthenol
Tremella Fuciformis Sporocarp Extract
Phenoxyethanol
Xanthan Gum
Sodium Phytate
Citric Acid
Betaine
Potassium Sorbate
Tocopherol
Water, Butylene Glycol, Alpha-Arbutin, Niacinamide, Sodium Hyaluronate, Hydroxyacetophenone, Citrus Limon Fruit Extract, Polyacrylate Crosspolymer-6, Glycerin, Panthenol, Tremella Fuciformis Sporocarp Extract, Phenoxyethanol, Xanthan Gum, Ethylhexylglycerin, Sodium Phytate, Citric Acid, Disodium EDTA, Betaine, Potassium Sorbate, Tocopherol
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.