MediCube Triple Collagen Serum Versus Numbuzin No.5 Vitamin Concentrated Serum

MediCube Triple Collagen Serum Versus Numbuzin No.5 Vitamin Concentrated Serum

This anti-aging serum is formulated around Niacinamide and Adenosine to soften the look of wrinkles.

This brightening serum is formulated around Niacinamide and Tranexamic Acid to fade the look of dark spots and brighten dull-looking skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Sea Water

Glycerin

Butylene Glycol

Cetyl Ethylhexanoate

1,2-Hexanediol

Alcohol Denat.

Niacinamide

Glycereth-26

Adenosine

Hydrolyzed Collagen

Hyaluronic Acid

Hydrolyzed Hyaluronic Acid

Sodium Hyaluronate

Soluble Collagen

Collagen Extract

Atelocollagen

Propanediol

Cyclopentasiloxane

Trehalose

Carbomer

Cetearyl Olivate

Tromethamine

Cyclohexasiloxane

Sorbitan Olivate

Ethylhexylglycerin

Disodium EDTA

Dimethicone

Parfum

Sea Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, 1,2-Hexanediol, Alcohol Denat., Niacinamide, Glycereth-26, Adenosine, Hydrolyzed Collagen, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Soluble Collagen, Collagen Extract, Atelocollagen, Propanediol, Cyclopentasiloxane, Trehalose, Carbomer, Cetearyl Olivate, Tromethamine, Cyclohexasiloxane, Sorbitan Olivate, Ethylhexylglycerin, Disodium EDTA, Dimethicone, Parfum

Vaccinium Vitis-Idaea Fruit Extract

Panthenol

Tranexamic Acid

Water

Neopentyl Glycol Dicaprate

Caprylic/Capric Triglyceride

Sorbitol

Bifida Ferment Lysate

Chondrus Crispus Extract

Butyrospermum Parkii Butter

Saccharum Officinarum Extract

Alpha-Arbutin

Melia Azadirachta Flower Extract

Ocimum Sanctum Leaf Extract

Melia Azadirachta Leaf Extract

Curcuma Longa Root Extract

Corallina Officinalis Extract

Tremella Fuciformis Extract

Pentylene Glycol

3-O-Ethyl Ascorbic Acid

Bisabolol

Hydrogenated Lecithin

Allantoin

Glutathione

Ceramide NP

Beta-Glucan

Dipotassium Glycyrrhizate

Tocopherol

Ascorbic Acid

Ascorbyl Glucoside

Tocopheryl Acetate

Hydroxypropyl Cyclodextrin

Ubiquinone

Thioctic Acid

Potassium Hydroxide

Behenyl Alcohol

Xanthan Gum

Vaccinium Vitis-Idaea Fruit Extract, Butylene Glycol, Niacinamide, Panthenol, Tranexamic Acid, Water, 1,2-Hexanediol, Neopentyl Glycol Dicaprate, Caprylic/Capric Triglyceride, Sorbitol, Bifida Ferment Lysate, Chondrus Crispus Extract, Butyrospermum Parkii Butter, Saccharum Officinarum Extract, Alpha-Arbutin, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Tremella Fuciformis Extract, Pentylene Glycol, Glycerin, 3-O-Ethyl Ascorbic Acid, Bisabolol, Tromethamine, Ethylhexylglycerin, Adenosine, Hydrogenated Lecithin, Allantoin, Glutathione, Ceramide NP, Beta-Glucan, Dipotassium Glycyrrhizate, Tocopherol, Ascorbic Acid, Ascorbyl Glucoside, Tocopheryl Acetate, Hydroxypropyl Cyclodextrin, Ubiquinone, Thioctic Acid, Potassium Hydroxide, Behenyl Alcohol, Carbomer, Xanthan Gum, Disodium EDTA

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

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