Skin science article
Medik8 Crystal Retinal 10 Versus Paula's Choice Discoloration Repair Serum
Medik8 Crystal Retinal 10 Versus Paula's Choice Discoloration Repair Serum This anti-aging serum is formulated around Retinal and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture. This brightening serum is formulated around Niac
Medik8 Crystal Retinal 10 Versus Paula's Choice Discoloration Repair Serum
This anti-aging serum is formulated around Retinal and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture.
This brightening serum is formulated around Niacinamide and Tranexamic Acid to fade the look of dark spots and brighten dull-looking skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Caprylic/Capric Triglyceride
Glycerin
Isododecane
Cetearyl Olivate
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Cetearyl Alcohol
PPG-12/Smdi Copolymer
Sorbitan Olivate
Tocopheryl Acetate
Titanium Dioxide
Eclipta Prostrata Extract
Cyclodextrin
Squalane
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Phenoxyethanol
Melia Azadirachta Leaf Extract
Hydroxypropyl Methylcellulose
Sodium Hyaluronate
Tetrahexyldecyl Ascorbate
Rubus Chamaemorus Seed Oil
Alumina
Isostearic Acid
Lecithin
Polyglyceryl-3 Polyricinoleate
Polyhydroxystearic Acid
Stearic Acid
Pentylene Glycol
Retinal
Moringa Oleifera Seed Oil
Sodium Polyaspartate
Climbazole
Disodium EDTA
Lonicera Japonica Flower Extract
Lonicera Caprifolium Flower Extract
Daucus Carota Sativa Seed Oil
Ethylhexylglycerin
3-O-Ethyl Ascorbic Acid
Dipteryx Odorata Bean Extract
Hydroxyacetophenone
Polysorbate 60
Sorbitan Isostearate
Vanilla Planifolia Fruit Extract
Decylene Glycol
1,2-Hexanediol
BHT
Coumarin
Water, Caprylic/Capric Triglyceride, Glycerin, Isododecane, Cetearyl Olivate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Alcohol, PPG-12/Smdi Copolymer, Sorbitan Olivate, Tocopheryl Acetate, Titanium Dioxide, Eclipta Prostrata Extract, Cyclodextrin, Squalane, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Phenoxyethanol, Melia Azadirachta Leaf Extract, Hydroxypropyl Methylcellulose, Sodium Hyaluronate, Tetrahexyldecyl Ascorbate, Rubus Chamaemorus Seed Oil, Alumina, Isostearic Acid, Lecithin, Polyglyceryl-3 Polyricinoleate, Polyhydroxystearic Acid, Stearic Acid, Pentylene Glycol, Retinal, Moringa Oleifera Seed Oil, Sodium Polyaspartate, Climbazole, Disodium EDTA, Lonicera Japonica Flower Extract, Lonicera Caprifolium Flower Extract, Daucus Carota Sativa Seed Oil, Ethylhexylglycerin, 3-O-Ethyl Ascorbic Acid, Dipteryx Odorata Bean Extract, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Vanilla Planifolia Fruit Extract, Decylene Glycol, 1,2-Hexanediol, BHT, Coumarin
Niacinamide
Tranexamic Acid
C13-15 Alkane
Dicaprylyl Carbonate
Ethyl Macadamiate
Behenyl Alcohol
Glyceryl Stearate
Butylene Glycol
Silybum Marianum Seed Oil
Tocopherol
Lactobacillus/Coconut Fruit Juice Ferment Filtrate
Bakuchiol
Xanthan Gum
Caprylyl Glycol
Hydrogenated Lecithin
Allantoin
Glycine Soja Oil
Hexylene Glycol
Boerhavia Diffusa Root Extract
Glycine Soja Sterols
Citric Acid
Sodium Phytate
Malic Acid
Water, Niacinamide, Glycerin, Tranexamic Acid, C13-15 Alkane, Caprylic/Capric Triglyceride, Dicaprylyl Carbonate, Ethyl Macadamiate, Behenyl Alcohol, Glyceryl Stearate, Butylene Glycol, Silybum Marianum Seed Oil, Tocopherol, Lactobacillus/Coconut Fruit Juice Ferment Filtrate, Lecithin, Bakuchiol, Xanthan Gum, Caprylyl Glycol, Hydrogenated Lecithin, Allantoin, Glycine Soja Oil, Hexylene Glycol, Boerhavia Diffusa Root Extract, Glycine Soja Sterols, Citric Acid, Sodium Phytate, Malic Acid, Phenoxyethanol, Ethylhexylglycerin
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!