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Skin science article

Missha Time Revolution Primestem100 Cream Versus Missha Time Revolution Prismestem100 Lifting Serum

Missha Time Revolution Primestem100 Cream Versus Missha Time Revolution Prismestem100 Lifting Serum This anti-aging night moisturizer is formulated around Niacinamide and Adenosine to soften the look of wrinkles and strengthen the skin barrier. This anti-aging

Missha Time Revolution Primestem100 Cream Versus Missha Time Revolution Prismestem100 Lifting Serum

This anti-aging night moisturizer is formulated around Niacinamide and Adenosine to soften the look of wrinkles and strengthen the skin barrier.

This anti-aging serum is formulated around Niacinamide and Adenosine to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Theobroma Grandiflorum Seed Butter

Squalane

Dicaprylyl Ether

Cyclohexasiloxane

Diisostearyl Malate

Cetearyl Alcohol

Pentylene Glycol

Butyrospermum Parkii Butter

Dipropylene Glycol

Hydrogenated Castor Oil Isostearate

Niacinamide

Phenyl Trimethicone

Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate

1,2-Hexanediol

Synthetic Beeswax

Glyceryl Stearate Se

Polymethylsilsesquioxane

C12-16 Alcohols

Helichrysum Italicum Flower Water

Panthenol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Cetearyl Olivate

Sorbitan Olivate

Palmitic Acid

Hydrogenated Lecithin

Cetearyl Glucoside

Glucose

Chlorella Vulgaris Extract

Parfum

Butylene Glycol

Carbomer

Copernicia Cerifera Wax

Tromethamine

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Angelica Archangelica Callus Extract

Fructooligosaccharides

Fructose

Xanthan Gum

Polyisobutene

Ethylhexylglycerin

Octanediol

Adenosine

Sodium Phytate

Melia Azadirachta Flower Extract

Caprylic/Capric Triglyceride

Ocimum Sanctum Leaf Extract

Melia Azadirachta Leaf Extract

Caprylyl/Capryl Glucoside

Sorbitan Oleate

Curcuma Longa Root Extract

Corallina Officinalis Extract

Dextrin

Theobroma Cacao Seed Extract

Tocopherol

Polyglyceryl-10 Oleate

Polyglyceryl-5 Oleate

Limnanthes Alba Seed Oil

Sodium Stearoyl Glutamate

Hydrogenated Vegetable Oil

Hydroxystearic Acid

Maltodextrin

Polyglyceryl-3 Methylglucose Distearate

Swertia Chirata Extract

Choleth-24

Ceramide NP

Water, Glycerin, Theobroma Grandiflorum Seed Butter, Squalane, Dicaprylyl Ether, Cyclohexasiloxane, Diisostearyl Malate, Cetearyl Alcohol, Pentylene Glycol, Butyrospermum Parkii Butter, Dipropylene Glycol, Hydrogenated Castor Oil Isostearate, Niacinamide, Phenyl Trimethicone, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, 1,2-Hexanediol, Synthetic Beeswax, Glyceryl Stearate Se, Polymethylsilsesquioxane, C12-16 Alcohols, Helichrysum Italicum Flower Water, Panthenol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Olivate, Sorbitan Olivate, Palmitic Acid, Hydrogenated Lecithin, Cetearyl Glucoside, Glucose, Chlorella Vulgaris Extract, Parfum, Butylene Glycol, Carbomer, Copernicia Cerifera Wax, Tromethamine, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Angelica Archangelica Callus Extract, Fructooligosaccharides, Fructose, Xanthan Gum, Polyisobutene, Ethylhexylglycerin, Octanediol, Adenosine, Sodium Phytate, Melia Azadirachta Flower Extract, Caprylic/Capric Triglyceride, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Caprylyl/Capryl Glucoside, Sorbitan Oleate, Curcuma Longa Root Extract, Corallina Officinalis Extract, Dextrin, Theobroma Cacao Seed Extract, Tocopherol, Polyglyceryl-10 Oleate, Polyglyceryl-5 Oleate, Limnanthes Alba Seed Oil, Sodium Stearoyl Glutamate, Hydrogenated Vegetable Oil, Hydroxystearic Acid, Maltodextrin, Polyglyceryl-3 Methylglucose Distearate, Swertia Chirata Extract, Choleth-24, Ceramide NP

Methylpropanediol

Betaine

Glycereth-26

Methyl Gluceth-20

Chondrus Crispus Extract

Xylitylglucoside

Polyglyceryl-10 Laurate

Saccharum Officinarum Extract

Anhydroxylitol

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Xylitol

Biosaccharide Gum-1

Hydrolyzed Hyaluronic Acid

Coccinia Indica Fruit Extract

Eclipta Prostrata Extract

Beta-Glucan

Water, Methylpropanediol, Glycerin, Betaine, Glycereth-26, Methyl Gluceth-20, Niacinamide, Pentylene Glycol, Helichrysum Italicum Flower Water, Chondrus Crispus Extract, Xylitylglucoside, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Anhydroxylitol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Angelica Archangelica Callus Extract, Tromethamine, 1,2-Hexanediol, Xylitol, Butylene Glycol, Xanthan Gum, Ethylhexylglycerin, Octanediol, Adenosine, Parfum, Biosaccharide Gum-1, Hydrolyzed Hyaluronic Acid, Sodium Phytate, Coccinia Indica Fruit Extract, Eclipta Prostrata Extract, Dextrin, Theobroma Cacao Seed Extract, Beta-Glucan, Tocopherol, Hydroxystearic Acid, Limnanthes Alba Seed Oil, Maltodextrin, Dipropylene Glycol, Hydrogenated Lecithin, Polyglyceryl-10 Oleate, Polyglyceryl-3 Methylglucose Distearate, Swertia Chirata Extract, Choleth-24, Ceramide NP

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

We don't have a description for Angelica Archangelica Callus Extract yet.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Choleth-24 comes from the cholesterol of lanolins. It is used as an emulsifier, or to help stabilize other ingredients.

This ingredient is soluble in both water and alcohol.

Dextrin is a starch-derived polysaccharide. It's made by partially breaking down corn, potato, or other plant starches.

Think of it as "half-processed" starch; it's less complex than the original but not fully broken down into sugar like maltodextrin.

In cosmetics, it mainly functions as a bulking agent, viscosity controller, binder, and absorbent. It helps thicken products, stabilize powders, and get certain textures a less "wet" feel.

This ingredient has a pretty solid safety profile; it's recognized as a safe food additive and its large molecular size means it doesn't meaningfully penetrate skin.

Human repeat insult patch tests using a rinse-off facial product containing 42.69% dextrin found no skin irritation or sensitization in 54 subjects.

Typical real-world usage is much lower: usually under 1% as a texture modifier and up to 40% in masks (rinse off products use less).

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

We don't have a description for Helichrysum Italicum Flower Water yet.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Hydroxystearic Acid is a C18 fatty acid derived from castor oil.

In cosmetics, it pulls triple duty:

Reported use concentrations for this ingredient go up to about 13.2% in makeup but tends to be lower in skincare.

Fungal acne: Since hydroxystearic acid is a C18 fatty acid, it falls into the C11-24 range that the Malassezia yeast can metabolize. This ingredient may not be fungal acne safe.

Limnanthes Alba Seed Oil is from the seeds of the meadowfoam plant. It is a skin conditioning agent and emollient that sits on top of skin to soften and hydrate it.

Over 98% of the oil is made up of long-chain fatty acids, mostly aachidic acid (61%), docosenoic acid (~16%), and docosadienoic acid (~18%).

This combination is not really found in any other plant oil and is the reason this is one of the most stable botanical oils available.

Some studies show it to be more stable than jojoba oil, helps a product resist going rancid, and can help extend the shelf life of a formula.

It also naturally contains vitamin E and phytosterols that give it a mild antioxidant benefit.

This ingredient is typically used from around 1% to fairly high levels since it's gentle; it's well-tolerated and low on the irritation scale.

Maltodextrin is a plant-derived carbohydrate made by breaking down starch (usually from corn, potato, or rice). In cosmetic formulas, it's a multitasking absorbent, emulsion stabilizer, and skin conditioner.

This ingredient is mostly used to stabilize emulsions and improve the powdery, non-greasy feel of products (like dry shampoos).

Safety-wise, this ingredient is pretty solid; it's even recognized as a food additive. Both animal and clinical studies found no adverse effects at the levels used in cosmetics.

Industry data shows this ingredient is used up to 45.7% in spray products and up to 33% in powder products.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

We don't have a description for Octanediol yet.

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Polyglyceryl-10 Oleate is made by combining ten units of glycerin with oleic acid.

According to a manufacturer, it is a low-irritation and hydrophilic (water loving) skin conditioning agent. It also improves the sensory feel and texture of a product.

Fungal acne note: Since this ingredient is made from oleic acid, it might not be fungal acne safe. The Malassezia yeast survives by eating certain fats, including oleic acid.

However, it should be noted this oleic acid is chemically bound to a large polyglycerol molecule, so it might not trigger fungal acne for everyone.

Polyglyceryl-3 Methylglucose Distearate is a plant-derived emulsifier whose only job is to keep the oily and watery parts of a formula blended so it doesn't separate into layers.

It's compatible with a wide-range of active ingredients and especially good at making emulsions survive heat/freeze cycles.

Typical use concentrations range from 2-3% and it works across a pH of 4.5-8.5.

This ingredient has been found safe to use in cosmetics and has a low irritation profile.

Because it's build on stearic acid, it may not be fungal acne safe. Stearic acid is a C18 fatty acid that falls within the range (C11-24) that Malassezia can feed on.

Sodium Phytate is the synthetic salt form of phytic acid. Phytic acid is an antioxidant and can be found in plant seeds.

Sodium Phytate is a chelating agent. Chelating agents help prevent metals from binding to water. This helps stabilize the ingredients and the product.

We don't have a description for Swertia Chirata Extract yet.

Theobroma Cacao Seed Extract comes from the Theobroma cacoa, or Cacao tree. Cacao trees are native to tropical landscapes.

Cacao seed extract contains antioxidants known as polyphenols.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
  2. 02So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
  3. 03You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
  4. 04Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
  5. 05What it does:
  6. 06Dimethicone comes in different viscosities:
  7. 07Depending on the viscosity, dimethicone has different properties.
  8. 08Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
  9. 09This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
  10. 10Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
  11. 11We don't have a description for Acrylates/Ethylhexyl Acrylate Copolymer yet.
  12. 12Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.
  13. 13As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.
  14. 14The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.
  15. 15True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).
  16. 16It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.
  17. 17Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.
  18. 18Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  19. 19Topically, glycerin does several things at once:
  20. 20Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Source · skinsort.com
02

Product index

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03

Comparison edit

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