Naturium Multi-Peptide Rich Cream Versus Depology Matriplex Peptide Intense Cream

Naturium Multi-Peptide Rich Cream Versus Depology Matriplex Peptide Intense Cream

This anti-aging moisturizer is formulated around Palmitoyl Pentapeptide-4 and Copper Tripeptide-1 to soften the look of wrinkles and strengthen the skin barrier.

This anti-aging moisturizer is formulated around Centella Asiatica Extract and Niacinamide to soften the look of wrinkles and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Caprylic/Capric Triglyceride

Glycerin

Octyldodecanol

Butylene Glycol

Polyglyceryl-3 Polyricinoleate

Cera Microcristallina

Magnesium Stearate

Polyglyceryl-3 Oleate

Undecane

1,2-Hexanediol

Polyglyceryl-20 Octadecabehenate/Laurate

Sorbitan Olivate

Stearalkonium Bentonite

Magnesium Sulfate

Linum Usitatissimum Seed Extract

Sodium Hyaluronate

Mannitol

Phosphatidylcholine

Palmitoyl Pentapeptide-4

Copper Tripeptide-1

Ferulic Acid

Gold

Tocopherol

Tridecane

Asiaticoside

Propylene Carbonate

Glyceryl Caprylate

Cetyl Alcohol

Decyl Glucoside

P-Anisic Acid

Xanthan Gum

Tocopheryl Acetate

Sodium Chloride

Sodium Benzoate

Potassium Sorbate

Phenoxyethanol

Water, Caprylic/Capric Triglyceride, Glycerin, Octyldodecanol, Butylene Glycol, Polyglyceryl-3 Polyricinoleate, Cera Microcristallina, Magnesium Stearate, Polyglyceryl-3 Oleate, Undecane, 1,2-Hexanediol, Polyglyceryl-20 Octadecabehenate/Laurate, Sorbitan Olivate, Stearalkonium Bentonite, Magnesium Sulfate, Linum Usitatissimum Seed Extract, Sodium Hyaluronate, Mannitol, Phosphatidylcholine, Palmitoyl Pentapeptide-4, Copper Tripeptide-1, Ferulic Acid, Gold, Tocopherol, Tridecane, Asiaticoside, Propylene Carbonate, Glyceryl Caprylate, Cetyl Alcohol, Decyl Glucoside, P-Anisic Acid, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol

Centella Asiatica Extract

Cyclohexasiloxane

Panthenol

Cetearyl Olivate

Melaleuca Alternifolia Leaf Extract

Niacinamide

Camellia Sinensis Leaf Extract

Stearyl Alcohol

Glyceryl Stearate

Melia Azadirachta Flower Extract

Melia Azadirachta Leaf Extract

Houttuynia Cordata Extract

Glycine Max Seed Extract

Sodium PCA

Sodium Polystyrene Sulfonate

Sorghum Bicolor Stalk Juice

Pentylene Glycol

Ethylhexylglycerin

Adenosine

Carbomer

Sodium Lactate

Hydroxypropyl Cyclodextrin

Polysorbate 20

Caprylyl Glycol

N-Prolyl Palmitoyl Tripeptide-56 Acetate

Palmitoyl Tripeptide-38

Madecassoside

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Asiatic Acid

Madecassic Acid

Centella Asiatica Extract, Butylene Glycol, Glycerin, Water, Cyclohexasiloxane, Panthenol, Sorbitan Olivate, Cetearyl Olivate, Melaleuca Alternifolia Leaf Extract, Niacinamide, 1,2-Hexanediol, Camellia Sinensis Leaf Extract, Stearyl Alcohol, Glyceryl Stearate, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Houttuynia Cordata Extract, Glycine Max Seed Extract, Sodium PCA, Sodium Polystyrene Sulfonate, Sodium Hyaluronate, Sorghum Bicolor Stalk Juice, Pentylene Glycol, Ethylhexylglycerin, Adenosine, Carbomer, Sodium Lactate, Hydroxypropyl Cyclodextrin, Polysorbate 20, Sodium Benzoate, Potassium Sorbate, Caprylyl Glycol, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Palmitoyl Tripeptide-38, Madecassoside, Asiaticoside, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Asiatic Acid, Madecassic Acid

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Asiaticoside comes from the super popular skin-soothing ingredient, Centella asiatica. It's the reason centella-based products have a strong reputation for repairing and calming skin, along with its sibling compound Madecassoside.

Research from 2016-2025 supports its role in:

You'll usually find this in concentrations between 0.2-5%.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.

This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.

This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.

According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.

Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.

Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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