Niod Copper Amino Isolate Serum 3 1:1 (CAIS3) Versus Youth To The People Triple Peptide + Cactus Oasis Serum

Niod Copper Amino Isolate Serum 3 1:1 (CAIS3) Versus Youth To The People Triple Peptide + Cactus Oasis Serum

This anti-aging serum is formulated around Tripeptide-29 and Tripeptide-1 to soften the look of wrinkles.

This anti-aging serum is formulated around Opuntia Ficus-Indica Stem Extract and Palmitoyl Tripeptide-1 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Tripeptide-29

Bis(Tripeptide-1) Copper Acetate

Tripeptide-1

Myristoyl Nonapeptide-3

Trifluoroacetyl Tripeptide-2

Acetyl Tetrapeptide-2

Sodium Hyaluronate Crosspolymer

Glycogen

Propanediol

Pentylene Glycol

Dextran

Dimethyl Isosorbide

Ethoxydiglycol

Isoceteth-20

Leuconostoc/Radish Root Ferment Filtrate

Caprylyl Glycol

Ethylhexylglycerin

Phenoxyethanol

Chlorphenesin

Water, Glycerin, Tripeptide-29, Bis(Tripeptide-1) Copper Acetate, Tripeptide-1, Myristoyl Nonapeptide-3, Trifluoroacetyl Tripeptide-2, Acetyl Tetrapeptide-2, Sodium Hyaluronate Crosspolymer, Glycogen, Propanediol, Pentylene Glycol, Dextran, Dimethyl Isosorbide, Ethoxydiglycol, Isoceteth-20, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin

Butylene Glycol

Opuntia Ficus-Indica Stem Extract

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-28

Sodium Hyaluronate

Hydrolyzed Sodium Hyaluronate

Sodium Acetylated Hyaluronate

Synthetic Sapphire

Citrullus Lanatus Fruit Extract

Lens Esculenta Fruit Extract

Pyrus Malus Fruit Extract

Nephelium Lappaceum Peel Extract

Sodium PCA

Glutathione

Malachite Extract

Citric Acid

Hydroxypropyl Methylcellulose

Tetrasodium Glutamate Diacetate

Polyglutamic Acid

1,2-Hexanediol

Sodium Lactate

Carbomer

Polysorbate 20

Hydroxyethylcellulose

Xanthan Gum

Water, Butylene Glycol, Glycerin, Pentylene Glycol, Opuntia Ficus-Indica Stem Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-28, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Synthetic Sapphire, Citrullus Lanatus Fruit Extract, Lens Esculenta Fruit Extract, Pyrus Malus Fruit Extract, Nephelium Lappaceum Peel Extract, Sodium PCA, Glutathione, Malachite Extract, Citric Acid, Hydroxypropyl Methylcellulose, Tetrasodium Glutamate Diacetate, Polyglutamic Acid, 1,2-Hexanediol, Caprylyl Glycol, Sodium Lactate, Carbomer, Propanediol, Polysorbate 20, Hydroxyethylcellulose, Xanthan Gum, Phenoxyethanol, Ethylhexylglycerin

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.

A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.

A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.

More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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