Nooance Copper Peptide Serum 2% Versus Niod Copper Amino Isolate Serum 3 1:1 (CAIS3)

Nooance Copper Peptide Serum 2% Versus Niod Copper Amino Isolate Serum 3 1:1 (CAIS3)

This anti-aging serum is formulated around Copper Tripeptide-1 to soften the look of wrinkles and strengthen the skin barrier.

This anti-aging serum is formulated around Tripeptide-29 and Tripeptide-1 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Pentylene Glycol

Methylpropanediol

1,2-Hexanediol

Panthenol

Alpha-Glucan Oligosaccharide

Bis(Tripeptide-1) Copper Acetate

Copper Tripeptide-1

Sodium Hyaluronate

Myristoyl Nonapeptide-3

Acetyl Tetrapeptide-2

N-Prolyl Palmitoyl Tripeptide-56 Acetate

Trifluoroacetyl Tripeptide-2

Palmitoyl Tetrapeptide-50

Tripeptide-1

Heptapeptide-15 Palmitate

Copper Palmitoyl Heptapeptide-14

Hydrolyzed Beta-Glucan

Sodium Carboxymethyl Beta-Glucan

Butylene Glycol

Citric Acid

Caprylyl Glycol

Sodium Benzoate

Potassium Sorbate

Dextran

Lactic Acid/Glycolic Acid Copolymer

Polyvinyl Alcohol

Sodium Hydroxide

Water, Glycerin, Pentylene Glycol, Methylpropanediol, 1,2-Hexanediol, Panthenol, Alpha-Glucan Oligosaccharide, Bis(Tripeptide-1) Copper Acetate, Copper Tripeptide-1, Sodium Hyaluronate, Myristoyl Nonapeptide-3, Acetyl Tetrapeptide-2, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Trifluoroacetyl Tripeptide-2, Palmitoyl Tetrapeptide-50, Tripeptide-1, Heptapeptide-15 Palmitate, Copper Palmitoyl Heptapeptide-14, Hydrolyzed Beta-Glucan, Sodium Carboxymethyl Beta-Glucan, Butylene Glycol, Citric Acid, Caprylyl Glycol, Sodium Benzoate, Potassium Sorbate, Dextran, Lactic Acid/Glycolic Acid Copolymer, Polyvinyl Alcohol, Sodium Hydroxide

Tripeptide-29

Sodium Hyaluronate Crosspolymer

Glycogen

Propanediol

Dimethyl Isosorbide

Ethoxydiglycol

Isoceteth-20

Leuconostoc/Radish Root Ferment Filtrate

Ethylhexylglycerin

Phenoxyethanol

Chlorphenesin

Water, Glycerin, Tripeptide-29, Bis(Tripeptide-1) Copper Acetate, Tripeptide-1, Myristoyl Nonapeptide-3, Trifluoroacetyl Tripeptide-2, Acetyl Tetrapeptide-2, Sodium Hyaluronate Crosspolymer, Glycogen, Propanediol, Pentylene Glycol, Dextran, Dimethyl Isosorbide, Ethoxydiglycol, Isoceteth-20, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This peptide is more commonly known as Thymulen 4 BG.

It is derived from a youth hormone called thymopoietin. Thymopoietin helps regulate the immune system and decreases naturally with age.

According to the manufacturer, this peptide boosts the skin's immune defenses and regenerates the outer layers of skin.

Bis(Tripeptide-1) Copper Acetate is a peptide.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Dextran is a sugar (polysaccharide) with skin hydrating properties.

Fun fact: Louis Pasteur first discovered this ingredient as a microbial product in wine.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Myristoyl Nonapeptide-3 is a peptide.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Trifluoroacetyl Tripeptide-2 is a peptide.

Tripeptide-1, also known as GHK), is a small, three-amino-acid peptide made up of glycine, histidine, and lysine.

This ingredient is a signal peptide and tell your skin to start producing fresh collagen, elastin, and other key structural proteins. This helps maintain firmness and reduces the look of fine-lines/wrinkles.

GHK is also unique because is also acts as a carrier peptide. It binds to and transports copper ions (forming the complex GHK-Cu). This form has been studied for decades and is known to stimulate wound healing, boost antioxidant defenses, and promote collagen/elastin synthesis.

In-vitro studies show both GHK and GHK-CU increase fibroblast activity that enhances the production of collagen, elastin, fibronectin, and other extracellular matrix components.

Both of these compounds also help balance enzymes that control collagen breakdown.

Human studies (in-vivo) using GHK-Cu creams have reported visible improvements to skin density, elasticity, and wrinkle depth after several weeks of use.

A small clinical study also found topical collagen tripeptide improved wrinkle appearance and skin elasticity in women after four weeks.

While these results are promising, most research is based on GHK-Cu or its derivatives rather than Tripeptide-1 alone (Palmitoyl Tripeptide-1 is a famous derivative of GHK). However, the consensus still supports GHK as a potent skin-signaling molecule that can encourage regeneration and maintain youthful looking skin.

Fun fact: GHK is a naturally occurring fragment of type 1 collagen that can be found in human plasma, saliva, and urine.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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